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Rat model of chroni...
Rat model of chronic tympanic membrane perforation : Ventilation tube with mitomycin C and dexamethasone
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- Wang, Allen Y. (författare)
- Univ Western Australia, Sch Surg, Ear Sci Ctr, Perth, WA 6009, Australia.;Ear Sci Inst Australia, Perth, WA, Australia.;Sir Charles Gairdner Hosp, Skull Base Surg, Dept Otolaryngol Head & Neck, Perth, WA, Australia.
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- Shen, Yi (författare)
- Univ Western Australia, Sch Surg, Ear Sci Ctr, Perth, WA 6009, Australia.;Ear Sci Inst Australia, Perth, WA, Australia.;Ningbo Lihuili Hosp, Ningbo Med Ctr, Dept Otolaryngol Head & Neck Surg, Ningbo, Zhejiang, Peoples R China.
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- Liew, Lawrence J. (författare)
- Univ Western Australia, Sch Surg, Ear Sci Ctr, Perth, WA 6009, Australia.;Ear Sci Inst Australia, Perth, WA, Australia.
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- Wang, Jeffrey T. (författare)
- Univ Western Australia, Sch Surg, Ear Sci Ctr, Perth, WA 6009, Australia.
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- von Unge, Magnus (författare)
- Uppsala universitet,Centrum för klinisk forskning, Västerås,Akershus Univ Hosp, Oslo, Norway.;Univ Oslo, N-0316 Oslo, Norway.
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- Atlas, Marcus D. (författare)
- Univ Western Australia, Sch Surg, Ear Sci Ctr, Perth, WA 6009, Australia.;Ear Sci Inst Australia, Perth, WA, Australia.;Sir Charles Gairdner Hosp, Skull Base Surg, Dept Otolaryngol Head & Neck, Perth, WA, Australia.
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- Dilley, Rodney J. (författare)
- Univ Western Australia, Sch Surg, Ear Sci Ctr, Perth, WA 6009, Australia.;Ear Sci Inst Australia, Perth, WA, Australia.
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Univ Western Australia, Sch Surg, Ear Sci Ctr, Perth, WA 6009, Australia;Ear Sci Inst Australia, Perth, WA, Australia.;Sir Charles Gairdner Hosp, Skull Base Surg, Dept Otolaryngol Head & Neck, Perth, WA, Australia. Univ Western Australia, Sch Surg, Ear Sci Ctr, Perth, WA 6009, Australia.;Ear Sci Inst Australia, Perth, WA, Australia.;Ningbo Lihuili Hosp, Ningbo Med Ctr, Dept Otolaryngol Head & Neck Surg, Ningbo, Zhejiang, Peoples R China. (creator_code:org_t)
- Elsevier BV, 2016
- 2016
- Engelska.
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Ingår i: International Journal of Pediatric Otorhinolaryngology. - : Elsevier BV. - 0165-5876 .- 1872-8464. ; 80:1, s. 61-68
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- Objective: Chronic tympanic membrane perforation (TMP) in a clinical setting may attract surgical intervention. With the advent of modern biomaterials, new options are available for myringoplasty but safety and efficacy need evaluation in a chronic TMP animal model. The aim of this study was to evaluate the efficacy of ventilation tube (VT) insertion in conjunction with topical application of mitomycin Cl dexamethasone (M/D) for the creation of chronic TMP in rats. Methods: Thirty male Sprague-Dawley rats underwent myringotomy of the right tympanic membrane (TM) and were divided into three experimental groups: spontaneous healing (myringotomy control), VT insertion for 2 weeks and VT insertion for 2 weeks in conjunction with topical application of M/D (VT-M/D). All TMs were regularly assessed by otoscopy for 10 weeks and then animals were sacrificed for histological evaluation. Results: In the VT-M/D group, seven out of ten (70%) perforations were patent at 10 weeks (mean patency, 57.9 days; P < 0.01). The VT group had two out of ten (20%) perforations patent at 10 weeks (mean patency, 26.5 days; P < 0.01), while all TMPs from the myringotomy control group were closed by day 9 (mean patency, 7.2 days). Histologically, the TMPs patent at week 10 had a stratified squamous epithelialized rim, keratinocyte layer thickening around the perforation edge as well as increased collagen deposition and macrophage infiltration. Conclusion: Chronic TMP in a rat model was successfully created by VT insertion and the efficacy was increased in combination with topical application of M/D.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Oto-rhino-laryngologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Otorhinolaryngology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
Nyckelord
- Tympanic membrane perforation
- Chronic
- Animal model
- Ventilation tube
- Mitomycin C
- Dexamethasone
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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