Sökning: WFRF:(Eliasson M) > Sox5 regulates beta...
Fältnamn | Indikatorer | Metadata |
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000 | 07502naa a2200697 4500 | |
001 | oai:gup.ub.gu.se/258243 | |
003 | SwePub | |
008 | 240528s2017 | |||||||||||000 ||eng| | |
009 | oai:lup.lub.lu.se:2d025ae1-70f7-4e53-80c9-06520c23440e | |
024 | 7 | a https://gup.ub.gu.se/publication/2582432 URI |
024 | 7 | a https://doi.org/10.1038/ncomms156522 DOI |
024 | 7 | a https://lup.lub.lu.se/record/2d025ae1-70f7-4e53-80c9-06520c23440e2 URI |
040 | a (SwePub)gud (SwePub)lu | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Axelsson, Annikau University of Gothenburg,Lund University,Lunds universitet,Diabetes - öpatofysiologi,Forskargrupper vid Lunds universitet,Diabetes - Islet Patophysiology,Lund University Research Groups,Diabetes - öcellsexocytos,Diabetes - Islet Cell Exocytosis,Biokemi och Strukturbiologi,Centrum för Molekylär Proteinvetenskap,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Biochemistry and Structural Biology,Center for Molecular Protein Science,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH,Sage Bionetworks4 aut0 (Swepub:lu)bioc-arr |
245 | 1 0 | a Sox5 regulates beta-cell phenotype and is reduced in type 2 diabetes |
264 | c 2017-06-06 | |
264 | 1 | b Springer Science and Business Media LLC,c 2017 |
520 | a Type 2 diabetes (T2D) is characterized by insulin resistance and impaired insulin secretion, but the mechanisms underlying insulin secretion failure are not completely understood. Here, we show that a set of co-expressed genes, which is enriched for genes with islet-selective open chromatin, is associated with T2D. These genes are perturbed in T2D and have a similar expression pattern to that of dedifferentiated islets. We identify Sox5 as a regulator of the module. Sox5 knockdown induces gene expression changes similar to those observed in T2D and diabetic animals and has profound effects on insulin secretion, including reduced depolarization-evoked Ca 2+-influx and β-cell exocytosis. SOX5 overexpression reverses the expression perturbations observed in a mouse model of T2D, increases the expression of key β-cell genes and improves glucose-stimulated insulin secretion in human islets from donors with T2D. We suggest that human islets in T2D display changes reminiscent of dedifferentiation and highlight SOX5 as a regulator of β-cell phenotype and function. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng |
653 | a Animalia | |
653 | a Journal Article | |
700 | 1 | a Mahdi, Tu Lund University,Lunds universitet,Diabetes - öpatofysiologi,Forskargrupper vid Lunds universitet,Diabetes - Islet Patophysiology,Lund University Research Groups,Hawler Medical University4 aut0 (Swepub:lu)med-tsr |
700 | 1 | a Nenonen, H. A.4 aut |
700 | 1 | a Singh, Taniau Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine4 aut0 (Swepub:lu)med-tis |
700 | 1 | a Hänzelmann, Su RWTH Aachen University4 aut0 (Swepub:lu)med-shz |
700 | 1 | a Wendt, A.4 aut |
700 | 1 | a Bagge, Annikau Lund University,Lunds universitet,Diabetes - molekylär metabolism,Forskargrupper vid Lunds universitet,Diabetes - Molecular Metabolism,Lund University Research Groups4 aut0 (Swepub:lu)med-aib |
700 | 1 | a Reinbothe, T. M.4 aut |
700 | 1 | a Millstein, J.u Sage Bionetworks4 aut |
700 | 1 | a Yang, Xu University of California, Los Angeles,Sage Bionetworks4 aut0 (Swepub:lu)bioc-xiy |
700 | 1 | a Zhang, B.u Sage Bionetworks,Icahn School of Medicine at Mount Sinai4 aut |
700 | 1 | a Gusmao, E. G.u RWTH Aachen University4 aut |
700 | 1 | a Shu, L.u University of California, Los Angeles4 aut |
700 | 1 | a Szabat, M.u University of British Columbia4 aut |
700 | 1 | a Tang, Yu Lund University,Lunds universitet,Diabetes - öpatofysiologi,Forskargrupper vid Lunds universitet,Diabetes - Islet Patophysiology,Lund University Research Groups,Tianjin Medical University4 aut0 (Swepub:lu)med-yot |
700 | 1 | a Wang, Jinlingu Lund University,Lunds universitet,Diabetes - öpatofysiologi,Forskargrupper vid Lunds universitet,Diabetes - Islet Patophysiology,Lund University Research Groups,Xiamen University4 aut0 (Swepub:lu)med-jiw |
700 | 1 | a Salö, S.u Lund University4 aut |
700 | 1 | a Eliasson, Lu Lund University,Lunds universitet,Diabetes - öcellsexocytos,Forskargrupper vid Lunds universitet,Diabetes - Islet Cell Exocytosis,Lund University Research Groups4 aut0 (Swepub:lu)mphy-lel |
700 | 1 | a Artner, Iu Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine4 aut0 (Swepub:lu)med-iba |
700 | 1 | a Fex, Mu Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Diabetes - molekylär metabolism,Celiac Disease and Diabetes Unit,Lund University Research Groups,Diabetes - Molecular Metabolism4 aut0 (Swepub:lu)medk-mf0 |
700 | 1 | a Johnson, J Du University of British Columbia4 aut0 (Swepub:lu)med-jkr |
700 | 1 | a Wollheim, C Bu Lund University,Lunds universitet,Translationell Muskel Forskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,University Medical Center, Geneva4 aut0 (Swepub:lu)med-cwe |
700 | 1 | a Derry, J. M. J.4 aut |
700 | 1 | a Mecham, B.u Trialomics4 aut |
700 | 1 | a Spégel, Pu Lund University,Lunds universitet,Diabetes - molekylär metabolism,Forskargrupper vid Lunds universitet,Centrum för analys och syntes,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Diabetes - Molecular Metabolism,Lund University Research Groups,Centre for Analysis and Synthesis,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH4 aut0 (Swepub:lu)tekn-psp |
700 | 1 | a Mulder, Hu Lund University,Lunds universitet,Diabetes - molekylär metabolism,Forskargrupper vid Lunds universitet,Diabetes - Molecular Metabolism,Lund University Research Groups4 aut0 (Swepub:lu)medk-hmu |
700 | 1 | a Costa, I. G.u RWTH Aachen University4 aut |
700 | 1 | a Zhang, Eu Lund University,Lunds universitet,Diabetes - öpatofysiologi,Forskargrupper vid Lunds universitet,Diabetes - Islet Patophysiology,Lund University Research Groups4 aut0 (Swepub:lu)med-ezg |
700 | 1 | a Rosengren, Anders H.,d 1978u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology4 aut0 (Swepub:gu)xrosen |
710 | 2 | a Diabetes - öpatofysiologib Forskargrupper vid Lunds universitet4 org |
773 | 0 | t Nature Communicationsd : Springer Science and Business Media LLCg 8q 8x 2041-1723 |
856 | 4 | u https://www.nature.com/articles/ncomms15652.pdf |
856 | 4 | u http://dx.doi.org/10.1038/ncomms15652x freey FULLTEXT |
856 | 4 8 | u https://gup.ub.gu.se/publication/258243 |
856 | 4 8 | u https://doi.org/10.1038/ncomms15652 |
856 | 4 8 | u https://lup.lub.lu.se/record/2d025ae1-70f7-4e53-80c9-06520c23440e |
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