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Lymphopenia at the ...
Lymphopenia at the time of transplant is associated with short-term mortality after deceased donor liver transplantation
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- Kitajima, Toshihiro (författare)
- Henry Ford Hlth Syst, Dept Transplant & Hepatobiliary Surg, Detroit, MI USA.
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- Rajendran, Luckshi (författare)
- Univ Toronto, Dept Surg, Div Gen Surg, Toronto, ON, Canada.
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- Lisznyai, Eric (författare)
- Henry Ford Hlth Syst, Dept Transplant & Hepatobiliary Surg, Detroit, MI USA.
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- Lu, Mei (författare)
- Henry Ford Hlth Syst, Dept Publ Hlth Sci, Detroit, MI USA.
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- Shamaa, Tayseer (författare)
- Henry Ford Hlth Syst, Dept Transplant & Hepatobiliary Surg, Detroit, MI USA.
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- Ivanics, Tommy (författare)
- Uppsala universitet,Gastrointestinalkirurgi,Henry Ford Hlth Syst, Dept Transplant & Hepatobiliary Surg, Detroit, MI USA.;Univ Toronto, Multiorgan Transplant Program, Toronto, ON, Canada.
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- Yoshida, Atsushi (författare)
- Henry Ford Hlth Syst, Dept Transplant & Hepatobiliary Surg, Detroit, MI USA.
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- Claasen, Marco P. A. W. (författare)
- Univ Toronto, Multiorgan Transplant Program, Toronto, ON, Canada.
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- Abouljoud, Marwan S. (författare)
- Henry Ford Hlth Syst, Dept Transplant & Hepatobiliary Surg, Detroit, MI USA.
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- Sapisochin, Gonzalo (författare)
- Univ Toronto, Dept Surg, Div Gen Surg, Toronto, ON, Canada.;Univ Toronto, Multiorgan Transplant Program, Toronto, ON, Canada.
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- Nagai, Shunji (författare)
- Henry Ford Hlth Syst, Dept Transplant & Hepatobiliary Surg, Detroit, MI USA.;2799 Grand Blvd,CFP 2, Detroit, MI 48202 USA.
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Henry Ford Hlth Syst, Dept Transplant & Hepatobiliary Surg, Detroit, MI USA Univ Toronto, Dept Surg, Div Gen Surg, Toronto, ON, Canada. (creator_code:org_t)
- Elsevier BV, 2023
- 2023
- Engelska.
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Ingår i: American Journal of Transplantation. - : Elsevier BV. - 1600-6135 .- 1600-6143. ; 23:2, s. 248-256
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Absolute lymphocyte count (ALC) is considered a surrogate marker for nutritional status and immunocompetence. We investigated the association between ALC and post-liver transplant outcomes in patients who received a deceased donor liver transplant (DDLT). Patients were categorized by ALC at liver transplant: low (<500/mu L), mid (500-1000/mu L), and high ALC (>1000/mu L). Our main analysis used retrospective data (2013-2018) for DDLT recipients from Henry Ford Hospital (United States); the results were further validated using data from the Toronto General Hospital (Canada). Among 449 DDLT recipients, the low ALC group demonstrated higher 180-day mortality than mid and high ALC groups (83.1% vs 95.8% and 97.4%, respectively; low vs mid: P =.001; low vs high: P <.001). A larger proportion of patients with low ALC died of sepsis compared with the combined mid/high groups (9.1% vs 0.8%; P <.001). In multivariable analysis, pretransplant ALC was associated with 180-day mortality (hazard ratio, 0.20; P =.004). Patients with low ALC had higher rates of bacteremia (22.7% vs 8.1%; P <.001) and cytomegaloviremia (15.2% vs 6.8%; P =.03) than patients with mid/high ALC. Low ALC pretransplant through postoperative day 30 was associated with 180-day mortality among patients who received rabbit antithymocyte globulin induction (P =.001). Pretransplant lymphopenia is associated with short-term mortality and a higher incidence of posttransplant infections in DDLT patients.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
Nyckelord
- clinical research/practice
- liver transplantation/hepatology
- patient survival
- complication: infectious
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Kitajima, Toshih ...
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Rajendran, Lucks ...
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Lisznyai, Eric
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Lu, Mei
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Shamaa, Tayseer
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Ivanics, Tommy
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Yoshida, Atsushi
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Claasen, Marco P ...
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Abouljoud, Marwa ...
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Sapisochin, Gonz ...
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Nagai, Shunji
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