Anti-SARS-CoV2 antibody responses in serum and cerebrospinal fluid of COVID-19 patients with neurological symptoms.

Cunningham, Janet L (author)

Virhammar, Johan (author)

Rönnberg, Bengt (author)

Castro Dopico, Xaquin (author)

Kolstad, Linda (author)

Albinsson, Bo (author)

Kumlien, Eva (author)

Nääs, Anja (author)

Klang, Andrea (author)

Westman, Gabriel (author)

Zetterberg, Henrik, 1973 (author): Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry

Frithiof, Robert (author)

Lundkvist, Åke (author)

Karlsson Hedestam, Gunilla B (author)

Rostami, Elham (author)

(creator_code:org_t)

2021-03-21
2022
English.
In: The Journal of infectious diseases. - : Oxford University Press (OUP). - 1537-6613 .- 0022-1899. ; 225:6, s. 965-970

Related links:: https://academic.oup...; show more...; https://gup.ub.gu.se...; https://doi.org/10.1...; show less...

Abstract Subject headings

Antibody responses to SARS-CoV-2 in serum and CSF from 16 COVID-19 patients with neurological symptoms were assessed using two independent methods. IgG specific for the virus spike protein was found in 81% of cases in serum and in 56% in CSF. SARS-CoV-2 IgG in CSF was observed in two cases with negative serology. Levels of IgG in both serum and CSF were associated with disease severity (p<0.05). All patients with elevated markers of CNS damage in CSF also had CSF antibodies (p=0.002), and CSF antibodies had the highest predictive value for neuronal damage markers of all tested clinical variables.

By the author/editor: Cunningham, Jane ...; Virhammar, Johan; Rönnberg, Bengt; Castro Dopico, X ...; Kolstad, Linda; Albinsson, Bo; show more...; Kumlien, Eva; Nääs, Anja; Klang, Andrea; Westman, Gabriel; Zetterberg, Henr ...; Frithiof, Robert; Lundkvist, Åke; Karlsson Hedesta ...; Rostami, Elham; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Neurosciences

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