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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00006457naa a2200577 4500
001oai:DiVA.org:oru-68770
003SwePub
008180907s2018 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:139012109
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-687702 URI
0247 a https://doi.org/10.1136/gutjnl-2017-3148532 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1390121092 URI
040 a (SwePub)orud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Ludvigsson, Jonas F.,d 1969-u Karolinska Institutet,Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Medical epidemiology and Biostatistics, Karolinska institutet, Stockholm, Sweden; Department of Pediatrics, Örebro University Hospital, Örebro, Sweden4 aut0 (Swepub:oru)jsln
2451 0a Outcome measures in coeliac disease trials :b the Tampere recommendations
264 c 2018-02-13
264 1b BMJ Publishing Group Ltd,c 2018
338 a print2 rdacarrier
500 a Funding Agencies:German Research Foundation (DFG)  Ministry of Research and Development (BMBF)  Leibniz Foundation  Biocard  Simtomax  Academy of Finland  Competitive Research Funding of the Tampere University Hospital  Sigrid Juselius Foundation   Hungarian Research Fund  NKFI 120392 Competitive State Research Financing of the Tampere University Hospital  9U038 
520 a Objective: A gluten-free diet is the only treatment option of coeliac disease, but recently an increasing number of trials have begun to explore alternative treatment strategies. We aimed to review the literature on coeliac disease therapeutic trials and issue recommendations for outcome measures.Design: Based on a literature review of 10 062 references, we (17 researchers and 2 patient representatives from 10 countries) reviewed the use and suitability of both clinical and non-clinical outcome measures. We then made expert-based recommendations for use of these outcomes in coeliac disease trials and identified areas where research is needed. Results: We comment on the use of histology, serology, clinical outcome assessment (including patient-reported outcomes), quality of life and immunological tools including gluten immunogenic peptides for trials in coeliac disease.Conclusion: Careful evaluation and reporting of outcome measures will increase transparency and comparability of coeliac disease therapeutic trials, and will benefit patients, healthcare and the pharmaceutical industry.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Gastroenterologi0 (SwePub)302132 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Gastroenterology and Hepatology0 (SwePub)302132 hsv//eng
7001 a Ciacci, Carolinau Coeliac Center at Department of Medicine and Surgery, Scuola Medica Salernitana, University of Salerno, Salerno, Italy4 aut
7001 a Green, Peter H. R.u Celiac Disease Center at Columbia University, New York, USA4 aut
7001 a Kaukinen, Katriu Celiac Disease Research Center, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland; Department of Internal Medicine, Tampere University Hospital, Tampere, Finland4 aut
7001 a Korponay-Szabo, Ilma R.u Coeliac Disease Centre, Heim Pál Children’s Hospital, Budapest, Hungary; Department of Paediatrics, Faculty of Medicine, University of Debrecen, Debrecen, Hungary4 aut
7001 a Kurppa, Kalleu Celiac Disease Research Center, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland; Department of Paediatrics, Tampere University Hospital, Tampere, Finland4 aut
7001 a Murray, Joseph A.u The Mayo Clinic, Rochester Minnesota, USA4 aut
7001 a Lundin, Knut Erik Aslaksenu Institute of Clinical Medicine and K. G. Jebsen Coeliac Disease Research Centre, Faculty of Medicine, University of Oslo, Oslo, Norway; Department of Gastroenterology, Oslo University Hospital, Oslo, Norway4 aut
7001 a Maki, Markku J.u Science Center, Tampere University Hospital, Tampere, Finland; Tampere Centre for Child Health Research, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland4 aut
7001 a Popp, Alinau Institute for Mother and Child Health Bucharest, University of Medicine and Pharmacy ’Carol Davila’, Bucharest, Romania; Tampere Centre for Child Health Research, University of Tampere, Tampere University Hospital, Tampere,Finland4 aut
7001 a Reilly, Norelle R.u Division of Pediatric Gastroenterology, Columbia University Medical Center, New York, USA; Celiac Disease Center, Department of Medicine, Columbia University Medical Center, New York, USA4 aut
7001 a Rodriguez-Herrera, Alfonsou Gupo IHP Pediatria, Sevilla, Spain4 aut
7001 a Sanders, David S.u Academic Unit of Gastroenterology, Royal Hallamshire Hospital, University of Sheffield, Sheffield, UK4 aut
7001 a Schuppan, Detlefu Celiac Center, University Medical Center, Johannes-Gutenberg University, Mainz, Germany; Division of Gastroenterology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA4 aut
7001 a Sleet, Sarahu Coeliac UK, Buckinghamshire, UK4 aut
7001 a Taavela, Juhau Tampere Centre for Child Health Research, University of Tampere, Tampere University Hospital, Tampere, Finland4 aut
7001 a Voorhees, Kristinu Continuum Clinical, Northbrook, Illinois, USA4 aut
7001 a Walker, Marjorie M.u Faculty of Health and Medicine, School of Medicine and Public Health, University of Newcastle, Newcastle, New South Wales, Australia4 aut
7001 a Leffler, Daniel A.u Celiac Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA4 aut
7102 a Örebro universitetb Institutionen för medicinska vetenskaper4 org
7730 t Gutd : BMJ Publishing Group Ltdg 67:8, s. 1410-1424q 67:8<1410-1424x 0017-5749x 1468-3288
8564 u https://doi.org/10.1136/gutjnl-2017-314853y Fulltext
8564 u https://gut.bmj.com/content/gutjnl/67/8/1410.full.pdf
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-68770
8564 8u https://doi.org/10.1136/gutjnl-2017-314853
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:139012109

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