The evolutionary and molecular history of a chikungunya virus outbreak lineage

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The evolutionary and molecular history of a chikungunya virus outbreak lineage

Krambrich, Janina (författare): Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi

Mihalič, Filip (författare): Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi

Gaunt, Michael W. (författare): Solena Ag, 300 Lincoln Center Dr. Foster City, CA 94404, USA

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Bohlin, Jon (författare): Infectious Disease Control and Environmental Health, Norwegian Institute of Public Health, Oslo, Norway

Hesson, Jenny C., 1980- (författare): Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Biologisk Myggkontroll, Nedre Dalälvens Utvecklings AB, Kölnavägen 25, 81197 Gysinge, Sweden

Lundkvist, Åke (författare): Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi

de Lamballerie, Xavier (författare): Unité des Virus Émergents (UVE), Aix-Marseille University - IRD 190 - Inserm 1207, Marseille, France

Li, Cixiu (författare): Key Laboratory of Emerging Infectious Diseases in Universities of Shandong, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian 271000, China; Department of Infectious Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China

Shi, Weifeng (författare): Department of Infectious Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China; Shanghai Institute of Virology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China

Pettersson, John H.-O. 1981- (författare): Uppsala universitet,Klinisk mikrobiologi,Department of Clinical Microbiology and Hospital Hygiene, Uppsala University Hospital, SE-751 85 Uppsala, Sweden; Department of Microbiology, Public Health Agency of Sweden, Nobels väg 18, SE-171 82 Solna, Sweden; Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Victoria, Australia

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Public Library of Science (PLoS), 2024
2024
Engelska.
Ingår i: PLoS Neglected Tropical Diseases. - : Public Library of Science (PLoS). - 1935-2727 .- 1935-2735. ; 18:7

Relaterad länk:: https://doi.org/10.1...; visa fler...; https://uu.diva-port... (primary) (Raw object); https://urn.kb.se/re...; https://doi.org/10.1...; visa färre...

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Abstract Ämnesord

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In 2018–2019, Thailand experienced a nationwide spread of chikungunya virus (CHIKV), with approximately 15,000 confirmed cases of disease reported. Here, we investigated the evolutionary and molecular history of the East/Central/South African (ECSA) genotype to determine the origins of the 2018–2019 CHIKV outbreak in Thailand. This was done using newly sequenced clinical samples from travellers returning to Sweden from Thailand in late 2018 and early 2019 and previously published genome sequences. Our phylogeographic analysis showed that before the outbreak in Thailand, the Indian Ocean lineage (IOL) found within the ESCA, had evolved and circulated in East Africa, South Asia, and Southeast Asia for about 15 years. In the first half of 2017, an introduction occurred into Thailand from another South Asian country, most likely Bangladesh, which subsequently developed into a large outbreak in Thailand with export to neighbouring countries. Based on comparative phylogenetic analyses of the complete CHIKV genome and protein modelling, we identified several mutations in the E1/E2 spike complex, such as E1 K211E and E2 V264A, which are highly relevant as they may lead to changes in vector competence, transmission efficiency and pathogenicity of the virus. A number of mutations (E2 G205S, Nsp3 D372E, Nsp2 V793A), that emerged shortly before the outbreak of the virus in Thailand in 2018 may have altered antibody binding and recognition due to their position. This study not only improves our understanding of the factors contributing to the epidemic in Southeast Asia, but also has implications for the development of effective response strategies and the potential development of new vaccines.

Ämnesord

NATURVETENSKAP -- Biologi -- Evolutionsbiologi (hsv//swe)
NATURAL SCIENCES -- Biological Sciences -- Evolutionary Biology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)

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Av författaren/redakt...: Krambrich, Janin ...; Mihalič, Filip; Gaunt, Michael W ...; Bohlin, Jon; Hesson, Jenny C. ...; Lundkvist, Åke; visa fler...; de Lamballerie, ...; Li, Cixiu; Shi, Weifeng; Pettersson, John ...; visa färre...

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NATURVETENSKAP: NATURVETENSKAP; och Biologi; och Evolutionsbiolog ...

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Infektionsmedici ...

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Av lärosätet: Uppsala universitet

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