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FältnamnIndikatorerMetadata
00006806naa a2200709 4500
001oai:lup.lub.lu.se:8fa0e5c7-3d8e-4015-9900-3631b13a0ccb
003SwePub
008240219s2024 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:237972325
009oai:prod.swepub.kib.ki.se:158410077
0247 a https://lup.lub.lu.se/record/8fa0e5c7-3d8e-4015-9900-3631b13a0ccb2 URI
0247 a https://doi.org/10.1200/JCO.23.004522 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:2379723252 URI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1584100772 URI
040 a (SwePub)lud (SwePub)kid (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Heymer, Emma J.u University of Birmingham4 aut
2451 0a Cumulative Absolute Risk of Subsequent Colorectal Cancer After Abdominopelvic Radiotherapy Among Childhood Cancer Survivors : A PanCareSurFup Study
264 1c 2024
300 a 12 s.
520 a PURPOSE Childhood cancer survivors are at the risk of developing subsequent colorectal cancers (CRCs), but the absolute risks by treatment modality are uncertain. We quantified the absolute risks by radiotherapy treatment characteristics using clinically accessible data from a Pan-European wide case-control study nested within a large cohort of childhood cancer survivors: the PanCareSurFup Study. METHODS Odds ratios (ORs) from a case-control study comprising 143 CRC cases and 143 controls nested within a cohort of 69,460 survivors were calculated. These, together with standardized incidence ratios for CRC for this cohort and European general population CRC incidence rates and survivors' mortality rates, were used to estimate cumulative absolute risks (CARs) by attained age for different categories of radiation to the abdominopelvic area. RESULTS Overall, survivors treated with abdominopelvic radiotherapy treatment (ART) were three times more likely to develop a subsequent CRC than those who did not receive ART (OR, 3.1 [95% CI, 1.4 to 6.6]). For male survivors treated with ART, the CAR was 0.27% (95% CI, 0.17 to 0.59) by age 40 years, 1.08% (95% CI, 0.69 to 2.34) by age 50 years (0.27% expected in the general population), and 3.7% (95% CI, 2.36 to 7.80) by age 60 years (0.95% expected). For female survivors treated with ART, the CAR was 0.29% (95% CI, 0.18 to 0.62) by age 40 years, 1.03% (95% CI, 0.65 to 2.22) by age 50 years (0.27% expected), and 3.0% (95% CI, 1.91 to 6.37) by age 60 years (0.82% expected). CONCLUSION We demonstrated that by age 40 years survivors of childhood cancer treated with ART already have a similar risk of CRC as those age 50 years in the general population for whom population-based CRC screening begins in many countries. This information should be used in the development of survivorship guidelines for the risk stratification of survivors concerning CRC risk.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
7001 a Jóźwiak, Katarzyna4 aut
7001 a Kremer, Leontien C.u Academic Medical Center of University of Amsterdam (AMC),Princess Maxima Center for Pediatric Oncology/Hematology4 aut
7001 a Winter, David L.u University of Birmingham4 aut
7001 a de Vathaire, Florentu Centre for Research in Epidemiology and Population Health (CESP)4 aut
7001 a Sunguc, Cerenu University of Birmingham4 aut
7001 a Sugden, Elaineu University of Birmingham4 aut
7001 a Kok, Judith L.u Princess Maxima Center for Pediatric Oncology/Hematology4 aut
7001 a van der Pal, Helena J.H.u Princess Maxima Center for Pediatric Oncology/Hematology4 aut
7001 a Hjorth, Larsu Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Sena effekter efter barncancerbehandling,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Late effects after childhood cancer treatment,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Skåne University Hospital4 aut0 (Swepub:lu)pedi-lhj
7001 a Jakab, Zsuzsannau Semmelweis University4 aut
7001 a Maule, Milena M.u Karolinska Institutet4 aut
7001 a Haupt, Riccardou Gaslini Children's Hospital4 aut
7001 a Bagnasco, Francescau Gaslini Children's Hospital4 aut
7001 a Terenziani, Monicau Istituto Nazionale dei Tumori4 aut
7001 a Diallo, Ibrahimau Centre for Research in Epidemiology and Population Health (CESP)4 aut
7001 a Gunnes, Maria W.u Cancer Registry of Norway, Institute of Population-Based Cancer Research,Norwegian Radium Hospital4 aut
7001 a Sommer, Gritu University of Bern4 aut
7001 a Zaletel, Lorna Zadravecu Institute of Oncology, Ljubljana4 aut
7001 a Kuehni, Claudia E.u University of Bern,University Children's Hospital Bern4 aut
7001 a Winther, Jeanette F.u Aarhus University Hospital,Danish Cancer Society4 aut
7001 a Lähteenmäki, Päivi M.u Turku University Hospital4 aut
7001 a Gudmundsdottir, Thorgerduru National University Hospital of Iceland,Danish Cancer Society4 aut
7001 a Allodji, Rodrigue S.u Centre for Research in Epidemiology and Population Health (CESP)4 aut
7001 a Skinner, Rodericku University of Newcastle upon Tyne4 aut
7001 a Ronckers, Cécile M.u Princess Maxima Center for Pediatric Oncology/Hematology,Carl von Ossietzky University of Oldenburg4 aut
7001 a Hawkins, Michael M.u University of Birmingham4 aut
7001 a Reulen, Raoul C.u University of Birmingham4 aut
7001 a Teepen, Jop C.u Princess Maxima Center for Pediatric Oncology/Hematology4 aut
7102 a University of Birminghamb Academic Medical Center of University of Amsterdam (AMC)4 org
7730 t Journal of Clinical Oncologyg 42:3, s. 336-347q 42:3<336-347x 0732-183X
7730 t Journal of clinical oncology : official journal of the American Society of Clinical Oncologyg 42:3, s. 336-347q 42:3<336-347x 1527-7755
8564 u http://dx.doi.org/10.1200/JCO.23.00452y FULLTEXT
8564 8u https://lup.lub.lu.se/record/8fa0e5c7-3d8e-4015-9900-3631b13a0ccb
8564 8u https://doi.org/10.1200/JCO.23.00452
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:237972325
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:158410077

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