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Duration of preclin...
Duration of preclinical, prodromal, and dementia stages of Alzheimer's disease in relation to age, sex, and APOE genotype
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- Vermunt, L. (author)
- Department of Neurology, Alzheimer Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
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- Sikkes, S. A. M. (author)
- Department of Neurology, Alzheimer Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
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- van den Hout, A. (author)
- Department of Statistical Science, University College London, London, UK
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show more...
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- Handels, R. (author)
- Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHeNS), Alzheimer Centrum Limburg, Maastricht University, Maastricht, The Netherlands
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- Bos, I. (author)
- Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHeNS), Alzheimer Centrum Limburg, Maastricht University, Maastricht, The Netherlands
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- van der Flier, W. M. (author)
- Department of Neurology, Alzheimer Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands; Department of Epidemiology and Biostatistics, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
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- Kern, Silke (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology,Department of Psychiatry and Neurochemistry, Neuropsychiatric Epidemiology Unit, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
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- Ousset, P. J. (author)
- CHU Toulouse, Gérontopôle and INSERM UMR 1027, Toulouse, France
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- Maruff, P. (author)
- Cogstate Ltd, Florey Institute, University of Melbourne, Melbourne, Australia
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- Skoog, Ingmar, 1954 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology,Department of Psychiatry and Neurochemistry, Neuropsychiatric Epidemiology Unit, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
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- Verhey, F. R. J. (author)
- Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHeNS), Alzheimer Centrum Limburg, Maastricht University, Maastricht, The Netherlands
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- Freund-Levi, Yvonne, 1956- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Neurobiology, Caring Sciences and Society (NVS), Karolinska University Hospital Huddinge, Stockholm, Sweden; Department of Old Age Psychiatry, Psychology and Neuroscience, King's College London, London, UK
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Tsolaki, M. (author)
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- Wallin, Åsa (author)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups
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- Rikkert, M. O. (author)
- Department of Geriatric Medicine, Radboudumc Alzheimer Centre, Radboud University Medical Center, Nijmegen, The Netherlands
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- Soininen, H. (author)
- Institute of Clinical Medicine, Neurology, University of Eastern Finland, Kuopio, Finland
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- Spiru, L. (author)
- "Carol Davila" University of Medicine and Pharmacy, Geriatrics-Gerontology and Old Age Psychiatry Clinical Department -"Elias" University Clinical Hospital, Bucarest, Romenia; "Ana Aslan" International Academy of Aging - The Memory Clinic and Longevity Medicine, Bucarest, Romenia
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- Zetterberg, Henrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden; Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London, UK; UK Dementia Research Institute at UCL, London, UK
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- Blennow, Kaj, 1958 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden
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- Scheltens, P. (author)
- Department of Neurology, Alzheimer Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
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- Muniz-Terrera, G. (author)
- Centre for Dementia Prevention, University of Edinburgh, Edinburgh, UK
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- Visser, P. J. (author)
- Karolinska Institutet
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Vellas, B. (author)
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Reynish, E. (author)
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Ousset, P. J. (author)
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Andrieu, S. (author)
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Burns, A. (author)
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Pasquier, F. (author)
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Frisoni, G. (author)
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Salmon, E. (author)
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Michel, J. P. (author)
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Zekry, D. S. (author)
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Boada, M. (author)
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Dartigues, J. F. (author)
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Olde-Rikkert, M. G. M. (author)
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Rigaud, A. S. (author)
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- Winblad, B. (author)
- Karolinska Institutet
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Malick, A. (author)
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Sinclair, A. (author)
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Frolich, L. (author)
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Scheltens, P. (author)
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Ribera, C. (author)
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Touchon, J. (author)
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Robert, P. (author)
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Salva, A. (author)
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Waldemar, G. (author)
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Bullock, R. (author)
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Tsolaki, M. (author)
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Rodriguez, G. (author)
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Spiru, L. (author)
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Jones, R. W. (author)
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Stiens, G. (author)
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Stoppe, G. (author)
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- Jonhagen, M. E. (author)
- Karolinska Institutet
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Cherubini, A. (author)
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Lage, P. M. (author)
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Gomezisla, T. (author)
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Camus, V. (author)
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Aguera-Morales, E. (author)
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Lopez, F. (author)
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Savy, S. (author)
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Cantet, C. (author)
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Coley, N. (author)
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(creator_code:org_t)
- 2019-06
- 2019
- English.
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In: Alzheimers & Dementia. - : Wiley. - 1552-5260 .- 1552-5279. ; 15:7, s. 888-898
- Related links:
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https://cris.maastri...
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http://dx.doi.org/10...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://lup.lub.lu.s...
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http://kipublication...
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Abstract
Subject headings
Close
- Introduction: We estimated the age-specific duration of the preclinical, prodromal, and dementia stages of Alzheimer's disease (AD) and the influence of sex, setting, apolipoprotein E (APOE) genotype, and cerebrospinal fluid tau on disease duration. Methods: We performed multistate modeling in a combined sample of 6 cohorts (n = 3268) with death as the end stage and estimated the preclinical, prodromal, and dementia stage duration. Results: The overall AD duration varied between 24 years (age 60) and 15 years (age 80). For individuals presenting with preclinical AD, age 70, the estimated preclinical AD duration was 10 years, prodromal AD 4 years, and dementia 6 years. Male sex, clinical setting, APOE epsilon 4 allele carriership, and abnormal cerebrospinal fluid tau were associated with a shorter duration, and these effects depended on disease stage. Discussion: Estimates of AD disease duration become more accurate if age, sex, setting, APOE, and cerebrospinal fluid tau are taken into account. This will be relevant for clinical practice and trial design. (C) 2019 the Alzheimer's Association. Published by Elsevier Inc. All rights reserved.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- Alzheimer's disease
- Disease duration
- Preclinical
- Prodromal
- Dementia
- APOE
- Clinical setting
- Progression
- Multistate model
- mild cognitive impairment
- beta-amyloid 1-42
- association workgroups
- diagnostic guidelines
- national institute
- risk-factors
- decline
- prevalence
- neurodegeneration
- recommendations
- Neurosciences & Neurology
- khann g
- 1984
- neurology
- v34
- p939
- APOE
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Vermunt, L.
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Sikkes, S. A. M.
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van den Hout, A.
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Handels, R.
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Bos, I.
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van der Flier, W ...
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show more...
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Kern, Silke
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Ousset, P. J.
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Maruff, P.
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Skoog, Ingmar, 1 ...
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Verhey, F. R. J.
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Freund-Levi, Yvo ...
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Tsolaki, M.
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Wallin, Åsa
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Rikkert, M. O.
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Soininen, H.
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Spiru, L.
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Zetterberg, Henr ...
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Blennow, Kaj, 19 ...
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Scheltens, P.
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Muniz-Terrera, G ...
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Visser, P. J.
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Vellas, B.
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Reynish, E.
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Andrieu, S.
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Burns, A.
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Pasquier, F.
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Frisoni, G.
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Salmon, E.
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Michel, J. P.
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Zekry, D. S.
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Boada, M.
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Dartigues, J. F.
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Olde-Rikkert, M. ...
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Rigaud, A. S.
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Winblad, B.
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Malick, A.
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Sinclair, A.
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Frolich, L.
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Ribera, C.
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Touchon, J.
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Robert, P.
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Salva, A.
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Waldemar, G.
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Bullock, R.
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Rodriguez, G.
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Jones, R. W.
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Stiens, G.
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Stoppe, G.
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Jonhagen, M. E.
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Cherubini, A.
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Lage, P. M.
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Gomezisla, T.
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Camus, V.
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Aguera-Morales, ...
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Lopez, F.
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Savy, S.
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Cantet, C.
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Coley, N.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
- Articles in the publication
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Alzheimers & Dem ...
- By the university
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University of Gothenburg
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Örebro University
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Lund University
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Karolinska Institutet