Defining the genomic signature of the parous breast

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Fältnamn	Indikatorer	Metadata
000		04233naa a2200613 4500
001		oai:DiVA.org:umu-62168
003		SwePub
008		121210s2012 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-621682 URI
024	7	a https://doi.org/10.1186/1755-8794-5-462 DOI
040		a (SwePub)umu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Peri, Suraj4 aut
245	1 0	a Defining the genomic signature of the parous breast
264		c 2012-10-11
264	1	b Springer Science and Business Media LLC,c 2012
338		a print2 rdacarrier
520		a Background: It is accepted that a woman's lifetime risk of developing breast cancer after menopause is reduced by early full term pregnancy and multiparity. This phenomenon is thought to be associated with the development and differentiation of the breast during pregnancy.Methods: In order to understand the underlying molecular mechanisms of pregnancy induced breast cancer protection, we profiled and compared the transcriptomes of normal breast tissue biopsies from 71 parous (P) and 42 nulliparous (NP) healthy postmenopausal women using Affymetrix Human Genome U133 Plus 2.0 arrays. To validate the results, we performed real time PCR and immunohistochemistry.Results: We identified 305 differentially expressed probesets (208 distinct genes). Of these, 267 probesets were up- and 38 down-regulated in parous breast samples; bioinformatics analysis using gene ontology enrichment revealed that up-regulated genes in the parous breast represented biological processes involving differentiation and development, anchoring of epithelial cells to the basement membrane, hemidesmosome and cell-substrate junction assembly, mRNA and RNA metabolic processes and RNA splicing machinery. The down-regulated genes represented biological processes that comprised cell proliferation, regulation of IGF-like growth factor receptor signaling, somatic stem cell maintenance, muscle cell differentiation and apoptosis.Conclusions: This study suggests that the differentiation of the breast imprints a genomic signature that is centered in the mRNA processing reactome. These findings indicate that pregnancy may induce a safeguard mechanism at post-transcriptional level that maintains the fidelity of the transcriptional process.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
653		a Gene expression profiling
653		a Pregnancy
653		a Breast morphology
653		a Breast differentiation
653		a Parous and nulliparous breast transcriptome
653		a Breast cancer risk
653		a Normal breast transcriptome
653		a Bioinformatics
700	1	a de Cicco, Ricardo Lopez4 aut
700	1	a Santucci-Pereira, Julia4 aut
700	1	a Slifker, Michael4 aut
700	1	a Ross, Eric A4 aut
700	1	a Russo, Irma H4 aut
700	1	a Russo, Patricia A4 aut
700	1	a Arslan, Alan A4 aut
700	1	a Belitskaya-Levy, Ilana4 aut
700	1	a Zeleniuch-Jacquotte, Anne4 aut
700	1	a Bordas, Palu Umeå universitet,Onkologi4 aut0 (Swepub:umu)palbos99
700	1	a Lenner, Peru Umeå universitet,Onkologi4 aut0 (Swepub:umu)pele0005
700	1	a Åhman, Janet4 aut
700	1	a Afanasyeva, Yelena4 aut
700	1	a Johansson, Robertu Umeå universitet,Institutionen för folkhälsa och klinisk medicin4 aut0 (Swepub:umu)rojo0001
700	1	a Sheriff, Fathima4 aut
700	1	a Hallmans, Göranu Umeå universitet,Näringsforskning4 aut0 (Swepub:umu)goha0001
700	1	a Toniolo, Paolo4 aut
700	1	a Russo, Jose4 aut
710	2	a Umeå universitetb Onkologi4 org
773	0	t BMC Medical Genomicsd : Springer Science and Business Media LLCg 5, s. 46-q 5<46-x 1755-8794
856	4	u https://bmcmedgenomics.biomedcentral.com/track/pdf/10.1186/1755-8794-5-46
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-62168
856	4 8	u https://doi.org/10.1186/1755-8794-5-46

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