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Sökning: WFRF:(Martinez Redondo Vicente) > The chaperone co-in...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004561naa a2200529 4500
001oai:DiVA.org:uu-303060
003SwePub
008160914s2016 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:134036930
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3030602 URI
0247 a https://doi.org/10.1126/scitranslmed.aaf70992 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1340369302 URI
040 a (SwePub)uud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Salah, Hebau Uppsala universitet,Klinisk neurofysiologi,Karolinska Inst, Dept Physiol & Pharmacol, SE-17777 Stockholm, Sweden.4 aut0 (Swepub:uu)hebsa359
2451 0a The chaperone co-inducer BGP-15 alleviates ventilation-induced diaphragm dysfunction
264 1b American Association for the Advancement of Science (AAAS),c 2016
338 a print2 rdacarrier
520 a Ventilation-induced diaphragm dysfunction (VIDD) is a marked decline in diaphragm function in response to mechanical ventilation, which has negative consequences for individual patients' quality of life and for the health care system, but specific treatment strategies are still lacking. We used an experimental intensive care unit (ICU) model, allowing time-resolved studies of diaphragm structure and function in response to long-term mechanical ventilation and the effects of a pharmacological intervention (the chaperone co-inducer BGP-15). The marked loss of diaphragm muscle fiber function in response to mechanical ventilation was caused by post-translational modifications (PTMs) of myosin. In a rat model, 10 days of BGP-15 treatment greatly improved diaphragm muscle fiber function (by about 100%), although it did not reverse diaphragm atrophy. The treatment also provided protection from myosin PTMs associated with HSP72 induction and PARP-1 inhibition, resulting in improvement of mitochondrial function and content. Thus, BGP-15 may offer an intervention strategy for reducing VIDD in mechanically ventilated ICU patients.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Cell- och molekylärbiologi0 (SwePub)301082 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Cell and Molecular Biology0 (SwePub)301082 hsv//eng
7001 a Li, Meishanu Karolinska Institutet4 aut
7001 a Cacciani, Nicolau Karolinska Institutet4 aut
7001 a Gastaldello, Stefanou Karolinska Institutet4 aut
7001 a Ogilvie, Hannahu Karolinska Inst, Dept Physiol & Pharmacol, SE-17777 Stockholm, Sweden.4 aut
7001 a Akkad, Hazemu Karolinska Institutet4 aut
7001 a Namuduri, Arvind Venkatu Karolinska Institutet4 aut
7001 a Morbidoni, Valeriau Univ Padua, Dept Womens & Childrens Hlth, Clin Genet Unit, I-35128 Padua, Italy.4 aut
7001 a Artemenko, Konstantin A.u Uppsala universitet,Analytisk kemi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)konar476
7001 a Balogh, Gaboru Hungarian Acad Sci, Biol Res Ctr, Inst Biochem, H-6726 Szeged, Hungary.4 aut
7001 a Martinez-Redondo, Vicenteu Karolinska Institutet4 aut
7001 a Jannig, Paulou Karolinska Institutet4 aut
7001 a Hedström, Yvetteu Karolinska Institutet4 aut
7001 a Dworkin, Barryu Karolinska Inst, Dept Physiol & Pharmacol, SE-17777 Stockholm, Sweden.;Penn State Univ, Dept Neurosci, Hershey, PA 17033 USA.4 aut
7001 a Bergquist, Jonasu Uppsala universitet,Analytisk kemi,Science for Life Laboratory, SciLifeLab,Univ Utah, Sch Med, Dept Pathol, Salt Lake City, UT 84112 USA.;Binzhou Med Univ, Precis Med, Yantai 264003, Shandong, Peoples R China.4 aut0 (Swepub:uu)jbe25356
7001 a Ruas, Jorgeu Karolinska Institutet4 aut
7001 a Vigh, Laszlou Hungarian Acad Sci, Biol Res Ctr, Inst Biochem, H-6726 Szeged, Hungary.4 aut
7001 a Salviati, Leonardou Univ Padua, Dept Womens & Childrens Hlth, Clin Genet Unit, I-35128 Padua, Italy.4 aut
7001 a Larsson, Larsu Karolinska Institutet4 aut
7102 a Uppsala universitetb Klinisk neurofysiologi4 org
7730 t Science Translational Medicined : American Association for the Advancement of Science (AAAS)g 8:350q 8:350x 1946-6234x 1946-6242
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-303060
8564 8u https://doi.org/10.1126/scitranslmed.aaf7099
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:134036930

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