WFRF:(Marzetti Emanuele)
Sökning: WFRF:(Marzetti Emanuele) > Circulating extrace...
LIBRIS Formathandbok (Information om MARC21)
| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04159naa a2200505 4500 | |
| 001 | oai:DiVA.org:su-198489 | |
| 003 | SwePub | |
| 008 | 211111s2022 | |||||||||||000 ||eng| | |
| 009 | oai:prod.swepub.kib.ki.se:147709099 | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-1984892 URI |
| 024 | 7 | a https://doi.org/10.4103/1673-5374.3209722 DOI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1477090992 URI |
| 040 | a (SwePub)sud (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a for2 swepub-publicationtype |
| 100 | 1 | a Picca, Annau Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Fondazione Policlinico Universitario “Agostino Gemelli” IRCCS, Italy4 aut |
| 245 | 1 0 | a Circulating extracellular vesicles :b friends and foes in neurodegeneration |
| 264 | 1 | b Medknow,c 2022 |
| 338 | a print2 rdacarrier | |
| 520 | a Extracellular vesicles have been identified as pivotal mediators of intercellular communication with critical roles in physiological and pathological conditions. Via this route, several molecules (e.g., nucleic acids, proteins, metabolites) can be transferred to proximal and distant targets to convey specific information. Extracellular vesicle-associated cargo molecules have been proposed as markers of several disease conditions for their potential of tracking down the generating cell. Indeed, circulating extracellular vesicles may represent biomarkers of dysfunctional cellular quality control systems especially in conditions characterized by the accrual of intracellular misfolded proteins. Furthermore, the identification of extracellular vesicles as tools for the delivery of nucleic acids or other cargo molecules to diseased tissues makes these circulating shuttles possible targets for therapeutic development. The increasing interest in the study of extracellular vesicles as biomarkers resides mainly in the fact that the identification of peripheral levels of extracellular vesicle-associated proteins might reflect molecular events occurring in hardly accessible tissues, such as the brain, thereby serving as a “brain liquid biopsy”. The exploitation of extracellular vesicles for diagnostic and therapeutic purposed might offer unprecedented opportunities to develop personalized approaches. Here, we discuss the bright and dark sides of extracellular vesicles in the setting of two main neurodegenerative diseases (i.e., Parkinson’s and Alzheimer’s diseases). A special focus will be placed on the possibility of using extracellular vesicles as biomarkers for the two conditions to enable disease tracking and treatment monitoring. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Cell- och molekylärbiologi0 (SwePub)301082 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Cell and Molecular Biology0 (SwePub)301082 hsv//eng |
| 653 | a Alzheimer’s disease | |
| 653 | a amyloid protein | |
| 653 | a exosomes | |
| 653 | a misfolded proteins | |
| 653 | a mitochondrial-derived vesicles | |
| 653 | a neuroinflammation | |
| 653 | a Parkinson’s disease | |
| 653 | a quality control | |
| 653 | a Tau protein | |
| 653 | a α-synuclein | |
| 700 | 1 | a Guerra, Flora4 aut |
| 700 | 1 | a Calvani, Riccardou Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Fondazione Policlinico Universitario “Agostino Gemelli” IRCCS, Italy4 aut |
| 700 | 1 | a Coelho-Junior, Hélio José4 aut |
| 700 | 1 | a Bucci, Cecilia4 aut |
| 700 | 1 | a Marzetti, Emanuele4 aut |
| 710 | 2 | a Stockholms universitetb Centrum för forskning om äldre och åldrande (ARC), (tills m KI)4 org |
| 773 | 0 | t Neural Regeneration Researchd : Medknowg 17:3, s. 534-542q 17:3<534-542x 1673-5374x 1876-7958 |
| 856 | 4 | u https://doi.org/10.4103/1673-5374.320972 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-198489 |
| 856 | 4 8 | u https://doi.org/10.4103/1673-5374.320972 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:147709099 |
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