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N-Cinnamoyltetraket...
N-Cinnamoyltetraketide Derivatives from the Leaves of Toussaintia orientalis
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Nyandoro, Stephen S., 1975 (author)
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Ndanu, J., 1970 (author)
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Munissi, Joan J. E., 1976 (author)
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- Gruhonjic, Amra (author)
- Gothenburg University,Göteborgs universitet,Sahlgrenska Cancer Center
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- Fitzpatrick, Paul A. (author)
- Gothenburg University,Göteborgs universitet,Sahlgrenska Cancer Center
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- Landberg, Göran, 1963 (author)
- Gothenburg University,Göteborgs universitet,Sahlgrenska Cancer Center
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Lu, You, 1980 (author)
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Wang, B., 1980 (author)
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Pan, F., 1980 (author)
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Rissanen, K., 1960 (author)
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- Erdelyi, Mate, 1975 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Svenskt NMR-centrum vid Göteborgs universitet,Department of Chemistry and Molecular Biology,Swedish NMR Centre at Göteborg University,organisk kemi
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Lu, Yu (author)
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(creator_code:org_t)
- 2015-07-27
- 2015
- English.
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In: Journal of natural products. - : American Chemical Society (ACS). - 0163-3864 .- 1520-6025. ; 78:8, s. 2045-2050
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https://doi.org/10.1...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Subject headings
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- Seven N-cinnamoyltetraketides (1–7), including the new Z-toussaintine E (2), toussaintine F (6), and toussaintine G (7), were isolated from the methanol extract of the leaves of Toussaintia orientalis using column chromatography and HPLC. The configurations of E-toussaintine E (1) and toussaintines A (3) and D (5) are revised based on single-crystal X-ray diffraction data from racemic crystals. Both the crude methanol extract and the isolated constituents exhibit antimycobacterial activities (MIC 83.3–107.7 μM) against the H37Rv strain of Mycobacterium tuberculosis. Compounds 1, 3, 4, and 5 are cytotoxic (ED50 15.3–105.7 μM) against the MDA-MB-231 triple negative aggressive breast cancer cell line.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Läkemedelskemi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medicinal Chemistry (hsv//eng)
- NATURVETENSKAP -- Kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences (hsv//eng)
- NATURVETENSKAP -- Annan naturvetenskap (hsv//swe)
- NATURAL SCIENCES -- Other Natural Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Andra medicinska och farmaceutiska grundvetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Other Basic Medicine (hsv//eng)
- NATURVETENSKAP -- Kemi -- Analytisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Analytical Chemistry (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)
- NATURVETENSKAP -- Kemi -- Organisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Organic Chemistry (hsv//eng)
Keyword
- N-Cinnamoyltetraketide
- naturprodukt
- traditional medicine
- Toussaintia orientalis
Publication and Content Type
- ref (subject category)
- art (subject category)
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Nyandoro, Stephe ...
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Ndanu, J., 1970
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Munissi, Joan J. ...
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Gruhonjic, Amra
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Fitzpatrick, Pau ...
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Landberg, Göran, ...
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show more...
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Lu, You, 1980
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Wang, B., 1980
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Pan, F., 1980
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Rissanen, K., 19 ...
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Erdelyi, Mate, 1 ...
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Lu, Yu
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medicinal Chemis ...
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Chemical Science ...
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Other Natural Sc ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Other Basic Medi ...
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Chemical Science ...
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and Analytical Chemi ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Pharmaceutical S ...
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Chemical Science ...
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- Articles in the publication
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Journal of natur ...
- By the university
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University of Gothenburg
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Uppsala University