Published registry-based pharmacoepidemiologic associations show limited concordance with agnostic medication-wide analyses

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Fältnamn	Indikatorer	Metadata
000		04399naa a2200409 4500
001		oai:DiVA.org:uu-510135
003		SwePub
008		230828s2023 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-5101352 URI
024	7	a https://doi.org/10.1016/j.jclinepi.2023.05.0142 DOI
040		a (SwePub)uu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Axfors, Cathrineu Uppsala universitet,Obstetrisk och reproduktiv hälsoforskning,Stanford Univ, Meta Res Innovat Ctr Stanford METRICS, Stanford, CA USA.;Univ Hosp Basel, Res Ctr Clin Neuroimmunol & Neurosci Basel RC2NB, Spitalstr 2, CH-4031 Basel, Switzerland.;Univ Basel, Spitalstr 2, CH-4031 Basel, Switzerland.4 aut0 (Swepub:uu)catax386
245	1 0	a Published registry-based pharmacoepidemiologic associations show limited concordance with agnostic medication-wide analyses
264	1	b Elsevier BV,c 2023
338		a electronic2 rdacarrier
520		a Objectives: To assess how the results of published national registry-based pharmacoepidemiology studies (where select associations are of interest) compare with an agnostic medication-wide approach (where all possible drug associations are tested).Study Design and Setting: We systematically searched for publications that reported drug associations with any, breast, colon/colorectal, or prostate cancer in the Swedish Prescribed Drug Registry. Results were compared against a previously performed agnostic medication-wide study on the same registry. Protocol: https://osf.io/kqj8n.Results: Most published studies (25/32) investigated previously reported associations. 421/913 (46%) associations had statistically significant results. 134 of the 162 unique drug-cancer associations could be paired with 70 associations in the agnostic study (corresponding drug categories and cancer types). Published studies reported smaller effect sizes and absolute effect sizes than the agnostic study, and generally used more adjustments. Agnostic analyses were less likely to report statistically significant protective associations (based on a multiplicity-corrected threshold) than their paired associations in published studies (McNemar odds ratio 0.13, P = 0.0022). Among 162 published associations, 36 (22%) showed increased risk signal and 25 (15%) protective signal at P < 0.05, while for agnostic associations, 237 (11%) showed increased risk signal and 108 (5%) protective signal at a multiplicity-corrected threshold. Associations belonging to drug categories targeted by individual published studies vs. nontargeted had smaller average effect sizes; smaller P values; and more frequent risk signals.Conclusion: Published pharmacoepidemiology studies using a national registry addressed mostly previously proposed associations, were mostly “negative”, and showed only modest concordance with their respective agnostic analyses in the same registry.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Farmakologi och toxikologi0 (SwePub)301022 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Pharmacology and Toxicology0 (SwePub)301022 hsv//eng
653		a Neoplasms
653		a Epidemiology
653		a Chemically induced
653		a Research methodology
653		a Data reporting
653		a Metaresearch
653		a Pharmacoepidemiology
700	1	a Patel, Chirag J.u Harvard Med Sch, Dept Biomed Informat, Boston, MA USA.4 aut
700	1	a Ioannidis, John P. A.u Stanford Univ, Meta Res Innovat Ctr Stanford METRICS, Stanford, CA USA.;Stanford Univ, Dept Med, Stanford, CA USA.;Stanford Univ, Dept Epidemiol & Populat Hlth, Stanford, CA USA.;Stanford Univ, Dept Biomed Data Sci, Stanford, CA USA.;Stanford Univ, Dept Stat, Stanford, CA USA.4 aut
710	2	a Uppsala universitetb Obstetrisk och reproduktiv hälsoforskning4 org
773	0	t Journal of Clinical Epidemiologyd : Elsevier BVg 160, s. 33-45q 160<33-45x 0895-4356x 1878-5921
856	4	u https://doi.org/10.1016/j.jclinepi.2023.05.014y Fulltext
856	4	u https://uu.diva-portal.org/smash/get/diva2:1791887/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-510135
856	4 8	u https://doi.org/10.1016/j.jclinepi.2023.05.014

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