Mesoporous silica particles potentiate antigen specific T cell responses

Kupferschmidt, Natalia (författare): Uppsala universitet,Nanoteknologi och funktionella material

Rahman Qazi, Khaleda (författare): Dept of Medicine Solna, Translational Immunology Unit, KI, Stockholm, Sweden

Kemi, Cecilia (författare): Experimental Asthma and Allergy Research, Centre for Allergy Research, The Institute of Environmental Medicine, KI, Stockholm, Sweden

Vallhov, Helen (författare): Dept of Medicine Solna, Translational Immunology Unit, KI, Stockholm, Sweden

Garcia-Bennett, Alfonso E (författare): Stockholm Univ, Dept Mat & Environm Chem, Stockholm, Sweden

Gabrielsson, Susanne (författare): Dept of Medicine Solna, Translational Immunology Unit, KI, Stockholm, Sweden

Scheynius, Annika (författare): Dept of Medicine Solna, Translational Immunology Unit, KI, Stockholm, Sweden

(creator_code:org_t)

Future Medicine Ltd, 2014
2014
Engelska.
Ingår i: Nanomedicine. - : Future Medicine Ltd. - 1743-5889 .- 1748-6963. ; 9:12, s. 1835-1846

Relaterad länk:: https://urn.kb.se/re...; visa fler...; https://doi.org/10.2...; visa färre...

Abstract Ämnesord

Stäng

Aim: To study the adjuvant effect of mesoporous silica particles and their capability of modifying an already existing allergic Th2-like immune response. Materials & methods: The adjuvant effect of Santa Barbara Amorphous-15 (SBA-15) mesoporous silica particles was studied in an antigen-specific ovalbumin (OVA) system in vitro and in vivo. The capacity of the OVA-loaded SBA-15 particles (SBA-15-OVA) to modify an existing immune response was assessed in a murine allergy model. Results: SBA-15-OVA induced significantly stronger OVA-specific splenocyte proliferation compared with OVA alone. Significantly higher IFN-γ production was observed in ex vivo OVA-stimulated splenocytes from SBA-15-OVA-immunized mice compared with mice injected with only SBA-15 or OVA. Treatment of OVA-sensitized mice with SBA-15-OVA modified the immune response with significantly lower serum levels of OVA-specific IgE and higher IgG levels compared with the alum-OVA-treated group. Conclusion: The results are promising for the continued development of mesoporous silica materials for therapeutic applications. Original submitted 18 January 2013; Revised submitted 30 August 2013

Av författaren/redakt...: Kupferschmidt, N ...; Rahman Qazi, Kha ...; Kemi, Cecilia; Vallhov, Helen; Garcia-Bennett, ...; Gabrielsson, Sus ...; visa fler...; Scheynius, Annik ...; visa färre...

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