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Mesoporous silica p...
Mesoporous silica particles potentiate antigen specific T cell responses
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- Kupferschmidt, Natalia (författare)
- Uppsala universitet,Nanoteknologi och funktionella material
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- Rahman Qazi, Khaleda (författare)
- Dept of Medicine Solna, Translational Immunology Unit, KI, Stockholm, Sweden
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- Kemi, Cecilia (författare)
- Experimental Asthma and Allergy Research, Centre for Allergy Research, The Institute of Environmental Medicine, KI, Stockholm, Sweden
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- Vallhov, Helen (författare)
- Dept of Medicine Solna, Translational Immunology Unit, KI, Stockholm, Sweden
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- Garcia-Bennett, Alfonso E (författare)
- Stockholm Univ, Dept Mat & Environm Chem, Stockholm, Sweden
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- Gabrielsson, Susanne (författare)
- Dept of Medicine Solna, Translational Immunology Unit, KI, Stockholm, Sweden
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- Scheynius, Annika (författare)
- Dept of Medicine Solna, Translational Immunology Unit, KI, Stockholm, Sweden
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(creator_code:org_t)
- Future Medicine Ltd, 2014
- 2014
- Engelska.
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Ingår i: Nanomedicine. - : Future Medicine Ltd. - 1743-5889 .- 1748-6963. ; 9:12, s. 1835-1846
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.2...
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Abstract
Ämnesord
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- Aim: To study the adjuvant effect of mesoporous silica particles and their capability of modifying an already existing allergic Th2-like immune response. Materials & methods: The adjuvant effect of Santa Barbara Amorphous-15 (SBA-15) mesoporous silica particles was studied in an antigen-specific ovalbumin (OVA) system in vitro and in vivo. The capacity of the OVA-loaded SBA-15 particles (SBA-15-OVA) to modify an existing immune response was assessed in a murine allergy model. Results: SBA-15-OVA induced significantly stronger OVA-specific splenocyte proliferation compared with OVA alone. Significantly higher IFN-γ production was observed in ex vivo OVA-stimulated splenocytes from SBA-15-OVA-immunized mice compared with mice injected with only SBA-15 or OVA. Treatment of OVA-sensitized mice with SBA-15-OVA modified the immune response with significantly lower serum levels of OVA-specific IgE and higher IgG levels compared with the alum-OVA-treated group. Conclusion: The results are promising for the continued development of mesoporous silica materials for therapeutic applications. Original submitted 18 January 2013; Revised submitted 30 August 2013
Ämnesord
- TEKNIK OCH TEKNOLOGIER -- Industriell bioteknik -- Medicinsk bioteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Industrial Biotechnology -- Medical Biotechnology (hsv//eng)
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