SwePub
Sök i LIBRIS databas

  Utökad sökning

WFRF:(Risal S)
 

Sökning: WFRF:(Risal S) > Prenatal androgen e...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00006649naa a2200769 4500
001oai:gup.ub.gu.se/304100
003SwePub
008240528s2021 | |||||||||||000 ||eng|
009oai:DiVA.org:oru-88535
009oai:DiVA.org:his-19435
009oai:prod.swepub.kib.ki.se:145772663
0247 a https://gup.ub.gu.se/publication/3041002 URI
0247 a https://doi.org/10.1038/s41398-020-01183-92 DOI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-885352 URI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-194352 URI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1457726632 URI
040 a (SwePub)gud (SwePub)orud (SwePub)hisd (SwePub)ki
041 a eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Risal, S.u Karolinska Institutet4 aut
2451 0a Prenatal androgen exposure causes a sexually dimorphic transgenerational increase in offspring susceptibility to anxiety disorders
264 c 2021-01-13
264 1b Springer Science and Business Media LLC,c 2021
500 a Funding Agencies:Swedish Medical Research Council (SMRC) 2014-2775 2018-02435 2014-2870 2018-02119Swedish Initiative for Research on Microdata in the Social And Medical Sciences (SIMSAM) 340-2013-5867SRP in Diabetes at Karolinska Institutet  Adlerbertska Foundation 2019/86Becas Chile-Conicyt 
500 a CC BY 4.0Correspondence: Elisabet Stener-Victorin (elisabet.stener-victorin@ki.se)
520 a If and how obesity and elevated androgens in women with polycystic ovary syndrome (PCOS) affect their offspring's psychiatric health is unclear. Using data from Swedish population health registers, we showed that daughters of mothers with PCOS have a 78% increased risk of being diagnosed with anxiety disorders. We next generated a PCOS-like mouse (F-0) model induced by androgen exposure during late gestation, with or without diet-induced maternal obesity, and showed that the first generation (F-1) female offspring develop anxiety-like behavior, which is transgenerationally transmitted through the female germline into the third generation of female offspring (F-3) in the androgenized lineage. In contrast, following the male germline, F-3 male offspring (mF(3)) displayed anxiety-like behavior in the androgenized and the obese lineages. Using a targeted approach to search for molecular targets within the amygdala, we identified five differentially expressed genes involved in anxiety-like behavior in F-3 females in the androgenized lineage and eight genes in the obese lineage. In mF(3) male offspring, three genes were dysregulated in the obese lineage but none in the androgenized lineage. Finally, we performed in vitro fertilization (IVF) using a PCOS mouse model of continuous androgen exposure. We showed that the IVF generated F-1 and F-2 offspring in the female germline did not develop anxiety-like behavior, while the F-2 male offspring (mF(2)) in the male germline did. Our findings provide evidence that elevated maternal androgens in PCOS and maternal obesity may underlie the risk of a transgenerational transmission of anxiety disorders in children of women with PCOS.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Psykiatri0 (SwePub)302152 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Psychiatry0 (SwePub)302152 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reproduktionsmedicin och gynekologi0 (SwePub)302202 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Obstetrics, Gynaecology and Reproductive Medicine0 (SwePub)302202 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Fysiologi0 (SwePub)301062 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Physiology0 (SwePub)301062 hsv//eng
653 a polycystic-ovary-syndrome
653 a diagnostic-criteria
653 a pregnant-women
653 a stress
653 a testosterone
653 a expression
653 a behavior
653 a sex
653 a pathophysiology
653 a differentiation
653 a Psychiatry
653 a Translationell medicin TRIM
7001 a Manti, M.u Karolinska Institutet4 aut
7001 a Lu, H. J.u Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden4 aut
7001 a Fornes, R.u Karolinska Institutet4 aut
7001 a Larsson, Henrik,d 1975-u Örebro universitet,Institutionen för medicinska vetenskaper,Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden / School of Medical Sciences, Örebro University, Sweden4 aut0 (Swepub:oru)hiln
7001 a Benrick, Anna,d 1979u Högskolan i Skövde,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology,Department of Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; School of Health Sciences, University of Skövde, Skövde, Sweden,Institutionen för hälsovetenskaper,Forskningsmiljön hälsa, hållbarhet och digitalisering,Translationell medicin TRIM, Translational Medicine4 aut0 (Swepub:his)benb
7001 a Deng, Q. L.u Karolinska Institutet4 aut
7001 a Cesta, C. E.u Karolinska Institutet4 aut
7001 a Rosenqvist, M. A.u School of Medical Sciences, Örebro University, Örebro, Sweden4 aut
7001 a Stener-Victorin, E.u Karolinska Institutet4 aut
7102 a Karolinska Institutetb Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden4 org
7730 t Translational Psychiatryd : Springer Science and Business Media LLCg 11:1q 11:1x 2158-3188
8564 u https://www.nature.com/articles/s41398-020-01183-9.pdf
8564 u https://doi.org/10.1038/s41398-020-01183-9y Fulltext
8564 u https://his.diva-portal.org/smash/get/diva2:1523288/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 8u https://gup.ub.gu.se/publication/304100
8564 8u https://doi.org/10.1038/s41398-020-01183-9
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-88535
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-19435
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:145772663

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy