Rehabilitation Before and After Autologous Haematopoietic Stem Cell Transplantation (AHSCT) for Patients With Multiple Sclerosis (MS): Consensus Guidelines and Recommendations for Best Clinical Practice on Behalf of the Autoimmune Diseases Working Party, Nurses Group, and Patient Advocacy Committee of the European Society for Blood and Marrow Transplantation (EBMT)

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Roberts, FionaHobbs Rehabil, Winchester, Hants, England (författare)

Rehabilitation Before and After Autologous Haematopoietic Stem Cell Transplantation (AHSCT) for Patients With Multiple Sclerosis (MS) : Consensus Guidelines and Recommendations for Best Clinical Practice on Behalf of the Autoimmune Diseases Working Party, Nurses Group, and Patient Advocacy Committee of the European Society for Blood and Marrow Transplantation (EBMT)

Artikel/kapitelEngelska2020

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2020-12-11
Frontiers Media SA,2020
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LIBRIS-ID:oai:DiVA.org:uu-432372
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-432372URI
https://doi.org/10.3389/fneur.2020.556141DOI

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Språk:engelska
Sammanfattning på:engelska

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Autologous haematopoietic stem cell transplantation (AHSCT) is increasingly used to treat people with multiple sclerosis (MS). Supported by an evolving evidence base, AHSCT can suppress active inflammation in the central nervous system and induce long-term changes in immune cell populations, thereby stabilizing, and, in some cases, reversing disability in carefully selected MS patients. However, AHSCT is an intensive chemotherapy-based procedure associated with intrinsic risks, including profound cytopenia, infection, and organ toxicity, accompanied by an on-going degree of immuno-compromise and general deconditioning, which can be associated with a transient increase in functional impairment in the early stages after transplantation. Although international guidelines and recommendations have been published for clinical and technical aspects of AHSCT in MS, there has been no detailed appraisal of the rehabilitation needed following treatment nor any specific guidelines as to how this is best delivered by hospital and community-based therapists and wider multidisciplinary teams in order to maximize functional recovery and quality of life. These expert consensus guidelines aim to address this unmet need by summarizing the evidence-base for AHSCT in MS and providing recommendations for current rehabilitation practice along with identifying areas for future research and development.

Ämnesord och genrebeteckningar

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Neurologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Neurology hsv//eng
autoimmune diseases
autologous haematopoietic stem cell transplantation
neurological diseases
multiple sclerosis
rehabilitation
physical therapy
exercise

Biuppslag (personer, institutioner, konferenser, titlar ...)

Hobbs, HelenHobbs Rehabil, Winchester, Hants, England (författare)
Jessop, HelenSheffield Teaching Hosp NHS Fdn Trust, Sheffield, S Yorkshire, England (författare)
Bozzolini, CristinaCareggi Univ Hosp, Florence, Italy (författare)
Burman, Joachim,1974-Uppsala universitet,Landtblom: Neurovetenskap(Swepub:uu)joabu293 (författare)
Greco, RaffaellaSan Raffaele Sci Hosp, Hematol & Bone Marrow Transplantat Unit, Ist Ricovero & Cura Carattere Sci IRCCS, Milan, Italy (författare)
Ismail, AzzaSheffield Teaching Hosp NHS Fdn Trust, Sheffield, S Yorkshire, England (författare)
Kazmi, MajidGuys Hosp, Dept Haematol, Kings Hlth Partners, London, England (författare)
Kirgizov, KirillNN Blokhin Natl Med Res Ctr Oncol, Inst Paediat Oncol & Haematol, Moscow, Russia (författare)
Mancardi, GianluigiUniv Genoa, Dept Neurosci, Genoa, Italy; Clin Sci Inst Maugeri, Genoa, Italy (författare)
Mawson, SusanUniv Sheffield, Sch Hlth & Related Res, Sheffield, S Yorkshire, England (författare)
Muraro, Paolo A.Imperial Coll London, Dept Brain Sci, London, England (författare)
Puyade, MathieuCHU Poitiers, Serv Med Interne & Malad Infect, Poitiers, France; CHU Poitiers, CIC 1402, Poitiers, France (författare)
Saccardi, RiccardoCareggi Univ Hosp, Florence, Italy (författare)
Withers, BarbaraUniv New South Wales Med, Dept Haematol & Blood Stem Cell Transplantat, St Vincents Hlth Network Sydney, Sydney, NSW, Australia; Univ New South Wales Med, St Vincents Clin Sch, Sydney, NSW, Australia (författare)
Verhoeven, BregjePatient Advocacy Comm, EBMT Execut Off, Barcelona, Spain (författare)
Sharrack, BasilSheffield Teaching Hosp NHS Fdn Trust, Sheffield, S Yorkshire, England; Univ Sheffield, Sch Hlth & Related Res, Sheffield, S Yorkshire, England (författare)
Snowden, John A.Sheffield Teaching Hosp NHS Fdn Trust, Sheffield, S Yorkshire, England (författare)
Hobbs Rehabil, Winchester, Hants, EnglandSheffield Teaching Hosp NHS Fdn Trust, Sheffield, S Yorkshire, England (creator_code:org_t)

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Ingår i:Frontiers in Neurology: Frontiers Media SA111664-2295

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