Disease burden due to enterotoxigenic Escherichia coli in the first 2 years of life in an urban community in Bangladesh.

A cohort of 321 children was followed from birth up to 2 years of age to determine the incidence of enterotoxigenic Escherichia coli (ETEC) in Bangladesh. The average number of diarrheal days and incidence rates were 6.6 and 2.3/child/year, respectively. ETEC was the most common pathogen and was isolated in 19.5% cases, with an incidence of 0.5 episode/child/year. The prevalence of rotavirus diarrhea was lower (10%). ETEC expressing the heat-stable enterotoxin (ST) was predominant. Strains isolated from diarrheal cases were positive for colonization factors (CFs) in higher frequency (66%) than from healthy children (33%) (P < 0.001). The heat-labile toxin (LT)-positive strains from healthy children were more often CF negative (92%) than those isolated from children with diarrhea (73%) (P < 0.001). In children with symptomatic or asymptomatic infections by CFA/I, CS1 plus CS3, CS2 plus CS3, or CS5 plus CS6 strains, a repeat episode of diarrhea or infection by the homologous CF type was uncommon. Repeat symptomatic infections were noted mostly for LT- and ST-expressing ETEC. ETEC diarrhea was more prevalent in children in the A and AB groups than in those in the O blood group (P = 0.032 to 0.023). Children with ETEC diarrhea were underweight and growth stunted at the 2-year follow-up period, showing the importance of strategies to prevent and decrease ETEC diarrheal morbidity in children.

MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Mikrobiologi inom det medicinska området hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Microbiology in the medical area hsv//eng
ABO Blood-Group System
Bacterial Toxins
biosynthesis
Bangladesh
epidemiology
Breast Feeding
Diarrhea
Infantile
epidemiology
microbiology
Enterotoxins
biosynthesis
Enzyme-Linked Immunosorbent Assay
Escherichia coli
classification
isolation & purification
Escherichia coli Infections
blood
epidemiology
microbiology
pathology
Escherichia coli Proteins
biosynthesis
Feces
microbiology
Female
Humans
Incidence
Infant
Infant
Newborn
Male
Pregnancy
Rotavirus
isolation & purification
Rotavirus Infections
epidemiology
Seasons
Urban Population

Saha, Amit (författare)
Ahmed, Tanvir,1970 (författare)
Al Tarique, Abdullah (författare)
Begum, Yasmin Ara (författare)
Svennerholm, Ann-Mari,1947Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology(Swepub:gu)xsannx (författare)
Göteborgs universitetInstitutionen för biomedicin, avdelningen för mikrobiologi och immunologi (creator_code:org_t)

Av författaren/redakt...: Qadri, Firdausi; Saha, Amit; Ahmed, Tanvir, 1 ...; Al Tarique, Abdu ...; Begum, Yasmin Ar ...; Svennerholm, Ann ...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Medicinska och f ...; och Mikrobiologi ino ...

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