Mitochondria and the Brain : Bioenergetics and Beyond

The view of mitochondria acting solely as a powerhouse of the cell is no longer accurate. Besides cell bioenergetics, primary targets of mitochondrial studies include their interplay with essential processes within the cell, including redox and calcium homeostasis, and apoptosis. Recent studies evidence the dynamic behavior of mitochondria, continuously moving, fusing, and dividing, and the interaction of these events with cellular degeneration and plasticity in neural cells. Our review summarizes novel data and technologies that are developed and applied to the identification and clarification of the mitochondrial role in neural plasticity using both cultured cells and in vivo approaches. The complete understanding and modulation of such mechanisms may represent a novel and promising therapeutic approach for treatment of diseases affecting central and peripheral nervous system.

Duarte, João M.N.Lund University,Lunds universitet,Diabetes och hjärnans funktion,Forskargrupper vid Lunds universitet,WCMM- Wallenberg center för molekylär medicinsk forskning,Medicinska fakulteten,Diabetes and Brain Function,Lund University Research Groups,WCMM-Wallenberg Centre for Molecular Medicine,Faculty of Medicine(Swepub:lu)jo2654du (author)
Schuck, Patrícia F.Pontifical Catholic University of Rio Grande do Sul (author)
Ferreira, Gustavo C.Federal University of Rio de Janeiro (author)
University of ToulouseDiabetes och hjärnans funktion (creator_code:org_t)

In:Neurotoxicity Research: Springer Science and Business Media LLC36:2, s. 219-2381029-84281476-3524

By the author/editor: Belenguer, Pasca ...; Duarte, João M.N ...; Schuck, Patrícia ...; Ferreira, Gustav ...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Neurosciences

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