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Expression of ETA a...
Expression of ETA and ETB receptor mRNA in human cerebral arteries
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Hansen-Schwartz, J (författare)
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Szok, D (författare)
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- Edvinsson, Lars (författare)
- Lund University,Lunds universitet,Medicin, Lund,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medicine, Lund,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine
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(creator_code:org_t)
- 2009-07-06
- 2002
- Engelska.
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Ingår i: British Journal of Neurosurgery. - : Informa UK Limited. - 0268-8697 .- 1360-046X. ; 16:2, s. 149-153
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The vascular effects of endothelins (ET) are in mammals mediated via two receptor subtypes, endothelin A (ETA, mainly constrictive) and endothelin B (ETB, mainly dilating) receptors. We have examined the presence of ETA and ETB receptor mRNA using the reverse transcription polymerase chain reaction (RT-PCR) in both normal human cerebral arteries and cerebral arteries from patients with cerebrovascular disease. Two vessel preparations were studied: macroscopic arteries and microvessels, the latter obtained through a sensitive separation method. In endothelial cells both ETA and ETB receptor mRNA was detected. In almost all samples from normal cerebral arteries only ETA receptor mRNA was detected, whereas in vessel samples from patients with cerebrovascular disease as well as cerebral neoplasms, additional ETB receptor mRNA was detected significantly more frequently. The pathophysiological significance of this difference is at present speculative, but does point to a vascular involvement of this receptor in cerebrovascular disease.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Annan klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Other Clinical Medicine (hsv//eng)
Nyckelord
- vascular smooth muscle cells
- human
- endothelium
- cerebral arteries
- endothelin receptors
- mRNA
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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