WFRF:(Sjoholm F)
Sökning: WFRF:(Sjoholm F) > Effects of glucagon...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03861naa a2200409 4500 | |
| 001 | oai:lup.lub.lu.se:00af0c4d-4158-46d9-afb0-ef363eea4ef9 | |
| 003 | SwePub | |
| 008 | 160401s2004 | |||||||||||000 ||eng| | |
| 009 | oai:prod.swepub.kib.ki.se:1939343 | |
| 024 | 7 | a https://lup.lub.lu.se/record/2625852 URI |
| 024 | 7 | a https://doi.org/10.1152/ajpendo.00237.20042 DOI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:19393432 URI |
| 040 | a (SwePub)lud (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a art2 swepub-publicationtype |
| 072 | 7 | a ref2 swepub-contenttype |
| 100 | 1 | a Nystrom, Tu Karolinska Institutet4 aut |
| 245 | 1 0 | a Effects of glucagon-like peptide-1 on endothelial function in type 2 diabetes patients with stable coronary artery disease |
| 264 | 1 | b American Physiological Society,c 2004 |
| 520 | a GLP-1 stimulates insulin secretion, suppresses glucagon secretion, delays gastric emptying, and inhibits small bowel motility, all actions contributing to the anti-diabetogenic peptide effect. Endothelial dysfunction is strongly associated with insulin resistance and type 2 diabetes mellitus and may cause the angiopathy typifying this debilitating disease. Therefore, interventions affecting both endothelial dysfunction and insulin resistance may prove useful in improving survival in type 2 diabetes patients. We investigated GLP-1's effect on endothelial function and insulin sensitivity (S-I) in two groups: 1) 12 type 2 diabetes patients with stable coronary artery disease and 2) 10 healthy subjects with normal endothelial function and S-I. Subjects underwent infusion of recombinant GLP-1 or saline in a random crossover study. Endothelial function was measured by postischemic FMD of brachial artery, using ultrasonography. S-I [in (10(-4) dl.kg(-1).min(-1))/(muU/ml)] was measured by hyperinsulinemic isoglycemic clamp technique. In type 2 diabetic subjects, GLP-1 infusion significantly increased relative changes in brachial artery diameter from baseline FMD(%) (3.1 +/- 0.6 vs. 6.6 +/- 1.0%, P < 0.05), with no significant effects on S-I (4.5 &PLUSMN; 0.8 vs. 5.2 &PLUSMN; 0.9, P = NS). In healthy subjects, GLP-1 infusion affected neither FMD(%) (11.9 &PLUSMN; 0.9 vs. 10.3 &PLUSMN; 1.0%, P = NS) nor S-I (14.8 &PLUSMN; 1.8 vs. 11.6 &PLUSMN; 2.0, P = NS). We conclude that GLP-1 improves endothelial dysfunction but not insulin resistance in type 2 diabetic patients with coronary heart disease. This beneficial vascular effect of GLP-1 adds yet another salutary property of the peptide useful in diabetes treatment. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Fysiologi0 (SwePub)301062 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Physiology0 (SwePub)301062 hsv//eng |
| 653 | a nitric oxide | |
| 653 | a insulin resistance | |
| 700 | 1 | a Gutniak, MK4 aut |
| 700 | 1 | a Zhang, QMu Karolinska Institutet4 aut |
| 700 | 1 | a Zhang, Fu Karolinska Institutet4 aut |
| 700 | 1 | a Holst, JJ4 aut |
| 700 | 1 | a Ahrén, Bou Lund University,Lunds universitet,Medicin, Lund,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medicine, Lund,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)med-bah |
| 700 | 1 | a Sjoholm, Au Karolinska Institutet4 aut |
| 710 | 2 | a Karolinska Institutetb Medicin, Lund4 org |
| 773 | 0 | t American Journal of Physiology: Endocrinology and Metabolismd : American Physiological Societyg 287:6, s. 1209-1215q 287:6<1209-1215x 1522-1555x 0193-1849 |
| 856 | 4 | u http://dx.doi.org/10.1152/ajpendo.00237.2004x freey FULLTEXT |
| 856 | 4 8 | u https://lup.lub.lu.se/record/262585 |
| 856 | 4 8 | u https://doi.org/10.1152/ajpendo.00237.2004 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:1939343 |
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