Search: WFRF:(Sommer Wolfgang H) >
mRNA GPR162 changes...
mRNA GPR162 changes are associated with decreased food intake in rat, and its human genetic variants with impairments in glucose homeostasis in two Swedish cohorts
-
- Caruso, Vanni (author)
- Uppsala universitet,Funktionell farmakologi,Univ Tasmania UTAS, Fac Pharm, Hobart, Tas 7001, Australia.
-
- Sreedharan, Smitha (author)
- Uppsala universitet,Funktionell farmakologi
-
- Carlini, Valeria P. (author)
- Uppsala universitet,Funktionell farmakologi,Univ Nacl Cordoba, Fac Ciencias Quim Haya Torre & Medina Allende, Dept Farmacol, Ciudad Univ, RA-5016 Cordoba, Argentina.
-
show more...
-
- Jacobsson, Josefin A. (author)
- Uppsala universitet,Funktionell farmakologi
-
- Haitina, Tatjana (author)
- Uppsala universitet,Funktionell farmakologi
-
- Hammer, Joanna (author)
- Uppsala universitet,Funktionell farmakologi
-
- Stephansson, Olga (author)
- Uppsala universitet,Funktionell farmakologi
-
- Crona, Filip (author)
- Uppsala universitet,Funktionell farmakologi
-
- Sommer, Wolfgang H. (author)
- Cent Inst Mental Hlth, Dept Psychopharmacol, Mannheim, Germany.
-
- Risérus, Ulf (author)
- Uppsala universitet,Klinisk nutrition och metabolism
-
- Lannfelt, Lars (author)
- Uppsala universitet,Geriatrik
-
- Marcus, Claude (author)
- Karolinska Institutet
-
- Heilig, Markus (author)
- NIAAA, Lab Clin & Translat Studies, NIH, Bethesda, MD USA.
-
- de Barioglio, Susana R. (author)
- Univ Nacl Cordoba, Fac Ciencias Quim Haya Torre & Medina Allende, Dept Farmacol, Ciudad Univ, RA-5016 Cordoba, Argentina.
-
- Fredriksson, Robert (author)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap,Molecular Neuropharmacology
-
- Schiöth, Helgi B. (author)
- Uppsala universitet,Funktionell farmakologi
-
show less...
-
(creator_code:org_t)
- Elsevier BV, 2016
- 2016
- English.
-
In: Gene. - : Elsevier BV. - 0378-1119 .- 1879-0038. ; 581:2, s. 139-145
- Related links:
-
https://urn.kb.se/re...
-
show more...
-
https://doi.org/10.1...
-
http://kipublication...
-
show less...
Abstract
Subject headings
Close
- G protein-coupled receptors (GPCRs) are a class of integral membrane proteins mediating intercellular interactions of fundamental physiological importance for survival including regulation of food intake, blood pressure, and hormonal sensing signaling, among other roles. Homeostatic alterations in the physiological status of GPCRs are often associated with underlying causes of disease, and to date, several orphan GPCRs are still uncharacterized. Findings from our previous study demonstrate that the Rhodopsin family protein GPR162 is widely expressed in GABAergic as well as other neurons within the mouse hippocampus, whereas extensive expression is observed in hypothalamus, amygdala, and ventral tegmental area, regions strictly interconnected and involved in the regulation of energy homeostasis and hedonic feeding. In this study, we provide a further anatomical characterization of GPR162 in mouse brain via in situ hybridization as well as detailed mRNA expression in a panel of rat tissues complementing a specie-specific mapping of the receptor. We also provide an attempt to demonstrate a functional implication of GPR162 in food intake-related behavior via antisense knockdown studies. Furthermore, we performed human genetic studies in which for the first time, variants of the GPR162 gene were associated with impairments in glucose homeostasis.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Keyword
- GPCRs
- GPR162
- Food intake
- Obesity
- Glucose homeostasis
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
-
Gene
(Search for host publication in LIBRIS)
To the university's database
- By the author/editor
-
Caruso, Vanni
-
Sreedharan, Smit ...
-
Carlini, Valeria ...
-
Jacobsson, Josef ...
-
Haitina, Tatjana
-
Hammer, Joanna
-
show more...
-
Stephansson, Olg ...
-
Crona, Filip
-
Sommer, Wolfgang ...
-
Risérus, Ulf
-
Lannfelt, Lars
-
Marcus, Claude
-
Heilig, Markus
-
de Barioglio, Su ...
-
Fredriksson, Rob ...
-
Schiöth, Helgi B ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Medical Genetics
- Articles in the publication
-
Gene
- By the university
-
Uppsala University
-
Karolinska Institutet