Cerebral energy metabolism during transient hyperglycemia in patients with severe brain trauma

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Fältnamn	Indikatorer	Metadata
000		04331naa a2200457 4500
001		oai:lup.lub.lu.se:6cf7ace9-da4d-4e89-8de2-357ad68b1495
003		SwePub
008		160401s2003 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:prod.swepub.kib.ki.se:1934221
024	7	a https://lup.lub.lu.se/record/3120692 URI
024	7	a https://doi.org/10.1007/s00134-003-1669-32 DOI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:19342212 URI
040		a (SwePub)lud (SwePub)ki
041		a engb eng
042		9 SwePub
072	7	a art2 swepub-publicationtype
072	7	a ref2 swepub-contenttype
100	1	a Diaz-Parejo, P4 aut
245	1 0	a Cerebral energy metabolism during transient hyperglycemia in patients with severe brain trauma
264		c 2003-03-25
264	1	b Springer Science and Business Media LLC,c 2003
520		a Objective: To study whether transient hyperglycemia adversely affects cerebral energy metabolism in patients with severe traumatic brain lesions. Design and setting: Prospective, nonrandomized study in the neurosurgical intensive care unit of a university hospital. Patients: 108 patients treated for severe traumatic brain lesions. Interventions: All patients were treated according to neurosurgical intensive care routine including monitoring of, intracranial pressure. One microdialysis catheter was inserted via a burr hole frontally to that used for the intraventricular catheter ("better" position). In patients with focal lesions one or more catheters were inserted into cerebral cortex surrounding an evacuated focal contusion or underlying an evacuated hematoma ("worse" position). Perfusion rate was 0.3 mul/min and samples were taken every. 30 or 60 min. The levels of glucose, pyruvate, lactate, glutamate, and glycerol were analyzed and displayed bedside. Measurements and results: There were 18 episodes of moderate (12-15 mmol/1) and 6 episodes of pronounced (>15 mmol/1) hyperglycemia. Moderate hyperglycemia did not change intracerebral levels of lactate, pyruvate, glutamate, glycerol, or lactate/pyruvate ratio. Lactate concentrations increased during pronounced hyperglycemia. Pronounced cerebral lactic acidosis and a moderate increase in interstitial glycerol concentration indicating cell membrane degradation was observed in a single patient with pronounced, long-lasting hyperglycemia. Conclusions: Cerebral energy metabolism was affected by transient hyperglycemia only at blood glucose concentration above 15 mmol/l as shown by a moderate increase in interstitial lactate level.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Anestesi och intensivvård0 (SwePub)302012 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Anesthesiology and Intensive Care0 (SwePub)302012 hsv//eng
653		a glutamate
653		a lactate
653		a glucose
653		a cerebral microdialysis
653		a hyperglycemia
653		a head injury
700	1	a Ståhl, Nilsu Lund University,Lunds universitet,Neurokirurgi,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurosurgery,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)nkir-nst
700	1	a Xu, WB4 aut
700	1	a Reinstrup, Peteru Lund University,Lunds universitet,Anestesiologi och intensivvård,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Anesthesiology and Intensive Care,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)anes-pre
700	1	a Ungerstedt, Uu Karolinska Institutet4 aut
700	1	a Nordström, Carl-Henriku Lund University,Lunds universitet,Neurokirurgi,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurosurgery,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)nkir-chn
710	2	a Neurokirurgib Sektion IV4 org
773	0	t Intensive Care Medicined : Springer Science and Business Media LLCg 29:4, s. 544-550q 29:4<544-550x 0342-4642x 1432-1238
856	4	u http://dx.doi.org/10.1007/s00134-003-1669-3y FULLTEXT
856	4 8	u https://lup.lub.lu.se/record/312069
856	4 8	u https://doi.org/10.1007/s00134-003-1669-3
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:1934221

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Av författaren/redakt...: Diaz-Parejo, P; Ståhl, Nils; Xu, WB; Reinstrup, Peter; Ungerstedt, U; Nordström, Carl- ...

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