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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 08007naa a2201897 4500 | |
| 001 | oai:DiVA.org:umu-165356 | |
| 003 | SwePub | |
| 008 | 191125s2019 | |||||||||||000 ||eng| | |
| 009 | oai:prod.swepub.kib.ki.se:142219468 | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1653562 URI |
| 024 | 7 | a https://doi.org/10.1016/j.jaci.2019.03.0272 DOI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1422194682 URI |
| 040 | a (SwePub)umud (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Östling, Jörgen4 aut |
| 245 | 1 0 | a IL-17-high asthma with features of a psoriasis immunophenotype |
| 264 | 1 | b Elsevier,c 2019 |
| 338 | a print2 rdacarrier | |
| 520 | a Background: The role of IL-17 immunity is well established in patients with inflammatory diseases, such as psoriasis and inflammatory bowel disease, but not in asthmatic patients, in whom further study is required.Objective: We sought to undertake a deep phenotyping study of asthmatic patients with upregulated IL-17 immunity.Methods: Whole-genome transcriptomic analysis was performed by using epithelial brushings, bronchial biopsy specimens (91 asthmatic patients and 46 healthy control subjects), and whole blood samples (n = 498) from the Unbiased Biomarkers for the Prediction of Respiratory Disease Outcomes (U-BIOPRED) cohort. Gene signatures induced in vitro by IL-17 and IL-13 in bronchial epithelial cells were used to identify patients with IL-17–high and IL-13–high asthma phenotypes.Results: Twenty-two of 91 patients were identified with IL-17, and 9 patients were identified with IL-13 gene signatures. The patients with IL-17–high asthma were characterized by risk of frequent exacerbations, airway (sputum and mucosal) neutrophilia, decreased lung microbiota diversity, and urinary biomarker evidence of activation of the thromboxane B2 pathway. In pathway analysis the differentially expressed genes in patients with IL-17-high asthma were shared with those reported as altered in psoriasis lesions and included genes regulating epithelial barrier function and defense mechanisms, such as IL1B, IL6, IL8, and β-defensin.Conclusion: The IL-17–high asthma phenotype, characterized by bronchial epithelial dysfunction and upregulated antimicrobial and inflammatory response, resembles the immunophenotype of psoriasis, including activation of the thromboxane B2 pathway, which should be considered a biomarker for this phenotype in further studies, including clinical trials targeting IL-17. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Lungmedicin och allergi0 (SwePub)302192 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Respiratory Medicine and Allergy0 (SwePub)302192 hsv//eng |
| 653 | a IL-17 | |
| 653 | a asthma | |
| 653 | a bronchial biopsies | |
| 653 | a bronchial brushings | |
| 653 | a biomarkers | |
| 653 | a psoriasis | |
| 700 | 1 | a van Geest, Marleen4 aut |
| 700 | 1 | a Schofield, James P. R.4 aut |
| 700 | 1 | a Jevnikar, Zala4 aut |
| 700 | 1 | a Wilson, Susan4 aut |
| 700 | 1 | a Ward, Jonathan4 aut |
| 700 | 1 | a Lutter, Rene4 aut |
| 700 | 1 | a Shaw, Dominick E.4 aut |
| 700 | 1 | a Bakke, Per S.4 aut |
| 700 | 1 | a Caruso, Massimo4 aut |
| 700 | 1 | a Dahlen, Sven-Eriku Karolinska Institutet4 aut |
| 700 | 1 | a Fowler, Stephen J.4 aut |
| 700 | 1 | a Horvath, Ildiko4 aut |
| 700 | 1 | a Krug, Norbert4 aut |
| 700 | 1 | a Montuschi, Paolo4 aut |
| 700 | 1 | a Sanak, Marek4 aut |
| 700 | 1 | a Sandström, Thomas,d 1957-u Umeå universitet,Avdelningen för medicin4 aut0 (Swepub:umu)thsa0001 |
| 700 | 1 | a Sun, Kai4 aut |
| 700 | 1 | a Pandis, Ioannis4 aut |
| 700 | 1 | a Auffray, Charles4 aut |
| 700 | 1 | a Sousa, Ana R.4 aut |
| 700 | 1 | a Guo, Yike4 aut |
| 700 | 1 | a Adcock, Ian M.4 aut |
| 700 | 1 | a Howarth, Peter4 aut |
| 700 | 1 | a Chung, Kian Fan4 aut |
| 700 | 1 | a Bigler, Jeanette4 aut |
| 700 | 1 | a Sterk, Peter J.4 aut |
| 700 | 1 | a Skipp, Paul J.4 aut |
| 700 | 1 | a Djukanovic, Ratko4 aut |
| 700 | 1 | a Vaarala, Outi4 aut |
| 700 | 1 | a Ahmed, H.4 aut |
| 700 | 1 | a Auffray, C.4 aut |
| 700 | 1 | a Bakke, P.4 aut |
| 700 | 1 | a Bansal, A. T.4 aut |
| 700 | 1 | a Baribaud, F.4 aut |
| 700 | 1 | a Bates, S.4 aut |
| 700 | 1 | a Bel, E. H.4 aut |
| 700 | 1 | a Bigler, J.4 aut |
| 700 | 1 | a Bisgaard, H.4 aut |
| 700 | 1 | a Boedigheimer, M. J.4 aut |
| 700 | 1 | a Bonnelykke, K.4 aut |
| 700 | 1 | a Brandsma, J.4 aut |
| 700 | 1 | a Brinkman, P.4 aut |
| 700 | 1 | a Bucchioni, E.4 aut |
| 700 | 1 | a Burg, D.4 aut |
| 700 | 1 | a Bush, A.4 aut |
| 700 | 1 | a Caruso, M.4 aut |
| 700 | 1 | a Chaiboonchoe, A.4 aut |
| 700 | 1 | a Chanez, P.4 aut |
| 700 | 1 | a Chung, K. F.4 aut |
| 700 | 1 | a Compton, C. H.4 aut |
| 700 | 1 | a Corfield, J.4 aut |
| 700 | 1 | a D'Amico, A.4 aut |
| 700 | 1 | a Dahlen, S. E.4 aut |
| 700 | 1 | a De Meulder, B.4 aut |
| 700 | 1 | a Djukanovic, R.4 aut |
| 700 | 1 | a Erpenbeck, V. J.4 aut |
| 700 | 1 | a Erzen, D.4 aut |
| 700 | 1 | a Fichtner, K.4 aut |
| 700 | 1 | a Fitch, N.4 aut |
| 700 | 1 | a Fleming, L. J.4 aut |
| 700 | 1 | a Formaggio, E.4 aut |
| 700 | 1 | a Fowler, S. J.4 aut |
| 700 | 1 | a Frey, U.4 aut |
| 700 | 1 | a Gahlemann, M.4 aut |
| 700 | 1 | a Geiser, T.4 aut |
| 700 | 1 | a Guo, Y.4 aut |
| 700 | 1 | a Hashimoto, S.4 aut |
| 700 | 1 | a Haughney, J.4 aut |
| 700 | 1 | a Hedlin, G.u Karolinska Institutet4 aut |
| 700 | 1 | a Hekking, P. W.4 aut |
| 700 | 1 | a Higenbottam, T.4 aut |
| 700 | 1 | a Hohlfeld, J. M.4 aut |
| 700 | 1 | a Holweg, C.4 aut |
| 700 | 1 | a Horvath, I.4 aut |
| 700 | 1 | a Howarth, P.4 aut |
| 700 | 1 | a James, A. J.u Karolinska Institutet4 aut |
| 700 | 1 | a Knowles, R.4 aut |
| 700 | 1 | a Knox, A. J.4 aut |
| 700 | 1 | a Krug, N.4 aut |
| 700 | 1 | a Lefaudeux, D.4 aut |
| 700 | 1 | a Loza, M. J.4 aut |
| 700 | 1 | a Lutter, R.4 aut |
| 700 | 1 | a Manta, A.4 aut |
| 700 | 1 | a Masefield, S.4 aut |
| 700 | 1 | a Matthews, J. G.4 aut |
| 700 | 1 | a Mazein, A.4 aut |
| 700 | 1 | a Meiser, A.4 aut |
| 700 | 1 | a Middelveld, R. J. M.u Karolinska Institutet4 aut |
| 700 | 1 | a Miralpeix, M.4 aut |
| 700 | 1 | a Montuschi, P.4 aut |
| 700 | 1 | a Mores, N.4 aut |
| 700 | 1 | a Murray, C. S.4 aut |
| 700 | 1 | a Musial, J.4 aut |
| 700 | 1 | a Myles, D.4 aut |
| 700 | 1 | a Pahus, L.4 aut |
| 700 | 1 | a Pandis, I.4 aut |
| 700 | 1 | a Pavlidis, S.4 aut |
| 700 | 1 | a Powell, P.4 aut |
| 700 | 1 | a Pratico, G.4 aut |
| 700 | 1 | a Valls, M. Puig4 aut |
| 700 | 1 | a Rao, N.4 aut |
| 700 | 1 | a Riley, J.4 aut |
| 700 | 1 | a Roberts, A.4 aut |
| 700 | 1 | a Roberts, G.4 aut |
| 700 | 1 | a Rowe, A.4 aut |
| 700 | 1 | a Sandström, T.4 aut |
| 700 | 1 | a Seibold, W.4 aut |
| 700 | 1 | a Selby, A.4 aut |
| 700 | 1 | a Shaw, D. E.4 aut |
| 700 | 1 | a Sigmund, R.4 aut |
| 700 | 1 | a Singer, F.4 aut |
| 700 | 1 | a Skipp, P. J.4 aut |
| 700 | 1 | a Sousa, A. R.4 aut |
| 700 | 1 | a Sterk, P. J.4 aut |
| 700 | 1 | a Sun, K.4 aut |
| 700 | 1 | a Thornton, B.4 aut |
| 700 | 1 | a van Aalderen, W. M.4 aut |
| 700 | 1 | a van Geest, M.4 aut |
| 700 | 1 | a Vestbo, J.4 aut |
| 700 | 1 | a Vissing, N. H.4 aut |
| 700 | 1 | a Wagener, A. H.4 aut |
| 700 | 1 | a Wagers, S. S.4 aut |
| 700 | 1 | a Weiszhart, Z.4 aut |
| 700 | 1 | a Wheelock, C. E.u Karolinska Institutet4 aut |
| 700 | 1 | a Wilson, S. J.4 aut |
| 710 | 2 | a Karolinska Institutetb Avdelningen för medicin4 org |
| 773 | 0 | t Journal of Allergy and Clinical Immunologyd : Elsevierg 144:5, s. 1198-1213q 144:5<1198-1213x 0091-6749x 1097-6825 |
| 856 | 4 | u http://www.jacionline.org/article/S0091674919304841/pdf |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-165356 |
| 856 | 4 8 | u https://doi.org/10.1016/j.jaci.2019.03.027 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:142219468 |
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- Jevnikar, Zala
- Wilson, Susan
- Ward, Jonathan
- visa fler...
- Lutter, Rene
- Shaw, Dominick E ...
- Bakke, Per S.
- Caruso, Massimo
- Dahlen, Sven-Eri ...
- Fowler, Stephen ...
- Horvath, Ildiko
- Krug, Norbert
- Montuschi, Paolo
- Sanak, Marek
- Sandström, Thoma ...
- Sun, Kai
- Pandis, Ioannis
- Auffray, Charles
- Sousa, Ana R.
- Guo, Yike
- Adcock, Ian M.
- Howarth, Peter
- Chung, Kian Fan
- Bigler, Jeanette
- Sterk, Peter J.
- Skipp, Paul J.
- Djukanovic, Ratk ...
- Vaarala, Outi
- Ahmed, H.
- Auffray, C.
- Bakke, P.
- Bansal, A. T.
- Baribaud, F.
- Bates, S.
- Bel, E. H.
- Bigler, J.
- Bisgaard, H.
- Boedigheimer, M. ...
- Bonnelykke, K.
- Brandsma, J.
- Brinkman, P.
- Bucchioni, E.
- Burg, D.
- Bush, A.
- Caruso, M.
- Chaiboonchoe, A.
- Chanez, P.
- Chung, K. F.
- Compton, C. H.
- Corfield, J.
- D'Amico, A.
- Dahlen, S. E.
- De Meulder, B.
- Djukanovic, R.
- Erpenbeck, V. J.
- Erzen, D.
- Fichtner, K.
- Fitch, N.
- Fleming, L. J.
- Formaggio, E.
- Fowler, S. J.
- Frey, U.
- Gahlemann, M.
- Geiser, T.
- Guo, Y.
- Hashimoto, S.
- Haughney, J.
- Hedlin, G.
- Hekking, P. W.
- Higenbottam, T.
- Hohlfeld, J. M.
- Holweg, C.
- Horvath, I.
- Howarth, P.
- James, A. J.
- Knowles, R.
- Knox, A. J.
- Krug, N.
- Lefaudeux, D.
- Loza, M. J.
- Lutter, R.
- Manta, A.
- Masefield, S.
- Matthews, J. G.
- Mazein, A.
- Meiser, A.
- Middelveld, R. J ...
- Miralpeix, M.
- Montuschi, P.
- Mores, N.
- Murray, C. S.
- Musial, J.
- Myles, D.
- Pahus, L.
- Pandis, I.
- Pavlidis, S.
- Powell, P.
- Pratico, G.
- Valls, M. Puig
- Rao, N.
- Riley, J.
- Roberts, A.
- Roberts, G.
- Rowe, A.
- Sandström, T.
- Seibold, W.
- Selby, A.
- Shaw, D. E.
- Sigmund, R.
- Singer, F.
- Skipp, P. J.
- Sousa, A. R.
- Sterk, P. J.
- Sun, K.
- Thornton, B.
- van Aalderen, W. ...
- van Geest, M.
- Vestbo, J.
- Vissing, N. H.
- Wagener, A. H.
- Wagers, S. S.
- Weiszhart, Z.
- Wheelock, C. E.
- Wilson, S. J.
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