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Attenuation of reac...
Attenuation of reactive gliosis in stroke-injured mouse brain does not affect neurogenesis from grafted human iPSC-derived neural progenitors
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- Laterza, Cecilia (författare)
- Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital
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- Uoshima, N. (författare)
- Tokyo Medical University,Skåne University Hospital,Lund University
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- Tornero, Daniel (författare)
- Lund University,Lunds universitet,Stem Cells & Restorative Neurology,Forskargrupper vid Lunds universitet,Lund University Research Groups,Skåne University Hospital
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- Wilhelmsson, Ulrika, 1970 (författare)
- University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience
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- Stokowska, Anna (författare)
- University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience
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- Ge, Ruimin (författare)
- Lund University,Lunds universitet,Neural stamcellsbiologi och terapi,Forskargrupper vid Lunds universitet,Neural stem cell biology and therapy,Lund University Research Groups,Skåne University Hospital
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- Pekny, Milos, 1965 (författare)
- University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience
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- Lindvall, Olle (författare)
- Lund University,Lunds universitet,Stem Cells & Restorative Neurology,Forskargrupper vid Lunds universitet,Lund University Research Groups,Skåne University Hospital
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- Kokaia, Zaal (författare)
- Lund University,Lunds universitet,Stem Cells & Restorative Neurology,Forskargrupper vid Lunds universitet,Lund University Research Groups,Skåne University Hospital
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(creator_code:org_t)
- 2018-02-05
- 2018
- Engelska.
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Ingår i: Plos One. - : Public Library of Science (PLoS). - 1932-6203. ; 13:2
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Abstract
Ämnesord
Stäng
- Induced pluripotent stem cells (iPSCs) or their progeny, derived from human somatic cells, can give rise to functional improvements after intracerebral transplantation in animal models of stroke. Previous studies have indicated that reactive gliosis, which is associated with stroke, inhibits neurogenesis from both endogenous and grafted neural stem/progenitor cells (NSPCs) of rodent origin. Here we have assessed whether reactive astrocytes affect the fate of human iPSC-derived NSPCs transplanted into stroke-injured brain. Mice with genetically attenuated reactive gliosis (deficient for GFAP and vimentin) were subjected to cortical stroke and cells were implanted adjacent to the ischemic lesion one week later. At 8 weeks after transplantation, immunohistochemical analysis showed that attenuated reactive gliosis did not affect neurogenesis or commitment towards glial lineage of the grafted NSPCs. Our findings, obtained in a human-to-mouse xenograft experiment, provide evidence that the reactive gliosis in stroke-injured brain does not affect the formation of new neurons from intracortically grafted human iPSC-derived NSPCs. However, for a potential clinical translation of these cells in stroke, it will be important to clarify whether the lack of effect of reactive gliosis on neurogenesis is observed also in a human-to-human experimental setting.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- fibrillary acidic protein
- central-nervous-system
- stem-cells
- astrocyte
- activation
- ischemic-stroke
- cortical-neurons
- mice deficient
- dentate
- gyrus
- human cns
- vimentin
- Science & Technology - Other Topics
- ates of america
- v103
- p17513
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Laterza, Cecilia
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Uoshima, N.
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Tornero, Daniel
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Wilhelmsson, Ulr ...
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Stokowska, Anna
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Ge, Ruimin
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Pekny, Milos, 19 ...
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Lindvall, Olle
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Kokaia, Zaal
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Neurovetenskaper
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Plos One
- Av lärosätet
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Göteborgs universitet
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Lunds universitet