WFRF:(Tanash Hanan)
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LIBRIS Formathandbok (Information om MARC21)
| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 05486naa a2200421 4500 | |
| 001 | oai:DiVA.org:umu-200881 | |
| 003 | SwePub | |
| 008 | 221110s2022 | |||||||||||000 ||eng| | |
| 009 | oai:lup.lub.lu.se:fb3d0c14-e077-44e3-819b-641c5c587160 | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-2008812 URI |
| 024 | 7 | a https://doi.org/10.1183/13993003.03200-20212 DOI |
| 024 | 7 | a https://lup.lub.lu.se/record/fb3d0c14-e077-44e3-819b-641c5c5871602 URI |
| 040 | a (SwePub)umud (SwePub)lu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Hiller, Adriana Mariau Lund University,Lunds universitet,Lungmedicin, allergologi och palliativ medicin,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Alfa-1-antritrypsinbrist,Forskargrupper vid Lunds universitet,Respiratory Medicine, Allergology, and Palliative Medicine,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Alpha-1-antitrypsin deficiency,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)ad3717io |
| 245 | 1 0 | a Cancer risk in severe alpha-1-antitrypsin deficiency |
| 264 | c 2022-03-31 | |
| 264 | 1 | b European Respiratory Society (ERS),c 2022 |
| 338 | a print2 rdacarrier | |
| 520 | a BACKGROUND: Severe alpha-1-antitrypsin deficiency (AATD), phenotype PiZZ, is a risk factor for pulmonary emphysema and liver disease, but its effect on cancer risk is unknown. Our aim was to evaluate the risk and the risk factors for incident cancer in PiZZ individuals compared with the general population with known smoking habits.METHODS: A longitudinal study of PiZZ individuals (n=1595) from the Swedish National AATD Register, and controls (n=5999) from Swedish population-based cohorts. Data on cancer and mortality were obtained by cross-linkage with national registers. Individuals who had undergone lung transplantation (n=10) and those with a cancer diagnosis within 5 years prior to inclusion (n=63) were excluded. The risk factors for developing cancer were analysed using proportional hazards and Fine-Gray regression models, adjusting for age, sex, smoking habits and the presence of liver disease.RESULTS: The median follow-up time was 17 years (interquartile range 11 years) for the whole study population. The incidence rates of hepatic and non-hepatic cancer per 1000 person-years were 1.6 (95% CI 1.1-2.3) and 8.5 (95% CI 7.2-10.0), respectively, for the PiZZ individuals, and 0.1 (95% CI 0.04-0.2) and 6.6 (95% CI 6.0-7.1), respectively, for the controls. The adjusted hazard ratios for hepatic and for non-hepatic cancer were 23.4 (95% CI 9.9-55.4) and 1.3 (95% CI 1.1-1.5), respectively, in the PiZZ individuals compared with the controls.CONCLUSION: These results suggest that individuals with severe AATD may have an increased risk of developing both hepatic and non-hepatic cancer, compared with the general population. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Lungmedicin och allergi0 (SwePub)302192 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Respiratory Medicine and Allergy0 (SwePub)302192 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
| 700 | 1 | a Ekström, Magnusu Lund University,Lunds universitet,Lungmedicin, allergologi och palliativ medicin,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Respiratory Medicine, Allergology, and Palliative Medicine,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)med-mue |
| 700 | 1 | a Piitulainen, Eevau Lund University,Lunds universitet,Lungmedicin, allergologi och palliativ medicin,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Alfa-1-antritrypsinbrist,Forskargrupper vid Lunds universitet,Respiratory Medicine, Allergology, and Palliative Medicine,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Alpha-1-antitrypsin deficiency,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)lung-epi |
| 700 | 1 | a Lindberg, Anneu Umeå University,Umeå universitet,Avdelningen för medicin4 aut0 (Swepub:umu)anelig02 |
| 700 | 1 | a Rönmark, Evau Umeå University,Umeå universitet,Avdelningen för hållbar hälsa4 aut0 (Swepub:umu)evra0004 |
| 700 | 1 | a Tanash, Hananu Lund University,Lunds universitet,Lungmedicin, allergologi och palliativ medicin,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Alfa-1-antritrypsinbrist,Forskargrupper vid Lunds universitet,Respiratory Medicine, Allergology, and Palliative Medicine,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Alpha-1-antitrypsin deficiency,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)lung-hat |
| 710 | 2 | a Lungmedicin, allergologi och palliativ medicinb Sektion II4 org |
| 773 | 0 | t European Respiratory Journald : European Respiratory Society (ERS)g 60:4q 60:4x 0903-1936x 1399-3003 |
| 856 | 4 | u http://dx.doi.org/10.1183/13993003.03200-2021y FULLTEXT |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-200881 |
| 856 | 4 8 | u https://doi.org/10.1183/13993003.03200-2021 |
| 856 | 4 8 | u https://lup.lub.lu.se/record/fb3d0c14-e077-44e3-819b-641c5c587160 |
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