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Weighty choices :
Weighty choices : selecting optimal G-CSF doses for stem cell mobilization to optimize yield
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- Farhadfar, Nosha (författare)
- Shands HealthCare & Univ Florida, Dept Med, Div Hematol & Oncol, Gainesville, FL USA
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- Hsu, Jack W. (författare)
- Shands HealthCare & Univ Florida, Dept Med, Div Hematol & Oncol, Gainesville, FL USA
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- Logan, Brent R. (författare)
- CIBMTR, Dept Med, Milwaukee, WI 53226 USA;Med Coll Wisconsin, Inst Hlth & Soc, Div Biostat, Milwaukee, WI 53226 USA
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- Sees, Jennifer A. (författare)
- CIBMTR, Natl Marrow Donor Program Be Match, Minneapolis, MN USA
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- Chitphakdithai, Pintip (författare)
- CIBMTR, Natl Marrow Donor Program Be Match, Minneapolis, MN USA
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- Sugrue, Michele W. (författare)
- Shands HealthCare & Univ Florida, Dept Med, Div Hematol & Oncol, Gainesville, FL USA
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- Abdel-Azim, Hisham (författare)
- Childrens Hosp Los Angeles, Los Angeles, CA 90027 USA
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- Anderlini, Paolo N. (författare)
- Univ Texas MD Anderson Canc Ctr, Dept Stem Cell Transplantat & Cellular Therapy, Houston, TX 77030 USA
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- Bredeson, Christopher (författare)
- Ottawa Hosp, Blood & Marrow Transplant Program, Ottawa, ON, Canada;Ottawa Hosp, Res Inst, Ottawa, ON, Canada
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- Chhabra, Saurabh (författare)
- Med Coll Wisconsin, Dept Med, Div Hematol Oncol, Milwaukee, WI 53226 USA
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- Diaz, Miguel Angel (författare)
- Hosp Infantil Univ Nino Jesus, Dept Hematol Oncol, Madrid, Spain
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- Ganguly, Siddhartha (författare)
- Univ Kansas Hlth Syst, Div Hematol Malignancy & Cellular Therapeut, Kansas City, KS USA
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- Hematti, Peiman (författare)
- Univ Wisconsin Hosp & Clin, Dept Med, Div Hematol Oncol Bone Marrow Transplantat, Madison, WI 53792 USA
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- Kamble, Rammurti T. (författare)
- Baylor Coll Med, Ctr Cell & Gene Therapy, Div Hematol & Oncol, Houston, TX 77030 USA
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- Kasow, Kimberly A. (författare)
- Univ N Carolina, Pediat Hematol Oncol Program, Chapel Hill, NC 27515 USA
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- Lazarus, Hillard M. (författare)
- Univ Hosp Cleveland, Med Ctr, Seidman Canc Ctr, Cleveland, OH 44106 USA
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- Lynch, Debra Kelly (författare)
- Shands HealthCare & Univ Florida, Dept Med, Div Hematol & Oncol, Gainesville, FL USA
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- Murthy, Hemant S. (författare)
- Shands HealthCare & Univ Florida, Dept Med, Div Hematol & Oncol, Gainesville, FL USA
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- Olsson, Richard (författare)
- Karolinska Institutet,Uppsala universitet,Centrum för klinisk forskning i Sörmland (CKFD),Karolinska Inst, Dept Lab Med, Div Therapeut Immunol, Stockholm, Sweden;
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- Papari, Mona (författare)
- ITxM Clin Serv Cord Blood Lab, Rosemont, IL USA
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- Przepiorka, Donna (författare)
- US FDA, Ctr Biol Evaluat & Res, North Potomac, MD USA
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- Savani, Bipin N. (författare)
- Vanderbilt Univ, Med Ctr, Dept Med, Div Hematol Oncol, Nashville, TN USA
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- Schears, Raquel (författare)
- Mayo Clin & Mayo Grad Sch Med, Dept Emergency Med, Rochester, MN USA
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- Seo, Sachiko (författare)
- Dokkyo Med Univ, Dept Hematol & Oncol, Mibu, Tochigi, Japan
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- Solh, Melhem M. (författare)
- Northside Hosp, Blood & Marrow Transplant Program, Atlanta, GA USA
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- Spitzer, Thomas (författare)
- Massachusetts Gen Hosp, Boston, MA 02114 USA
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- Yared, Jean A. (författare)
- Univ Maryland, Dept Med, Greenebaum Canc Ctr, Blood & Marrow Transplantat Program,Div Hematol O, Baltimore, MD 21201 USA
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- Pulsipher, Michael A. (författare)
- Childrens Hosp Los Angeles, USC Keck Sch Med, Div Hematol Blood & Marrow Transplantat, Los Angeles, CA 90027 USA
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- Shah, Nirali N. (författare)
- NCI, Pediat Oncol Branch, Ctr Canc Res, NIH, Bethesda, MD 20892 USA
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- Switzer, Galen E. (författare)
- Univ Pittsburgh, Dept Med, Pittsburgh, PA USA
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- Confer, Dennis L. (författare)
- CIBMTR, Natl Marrow Donor Program Be Match, Minneapolis, MN USA;Natl Marrow Donor Program Be Match, Minneapolis, MN USA
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- Shaw, Bronwen E. (författare)
- CIBMTR, Dept Med, Milwaukee, WI 53226 USA
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- Wingard, John R. (författare)
- Shands HealthCare & Univ Florida, Dept Med, Div Hematol & Oncol, Gainesville, FL USA
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(creator_code:org_t)
- 2020-02-24
- 2020
- Engelska.
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Ingår i: Blood Advances. - : AMER SOC HEMATOLOGY. - 2473-9529 .- 2473-9537. ; 4:4, s. 706-716
- Relaterad länk:
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https://ashpublicati...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- There are limited data on the effect of donor body mass index (BMI) on peripheral blood stem cell (PBSC) mobilization response to granulocyte colony-stimulating factor (G-CSF), especially in unrelated donors. Obesity has been associated with persistent leukocytosis, elevated circulating progenitor cells, and enhanced stem cell mobilization. Therefore, we hypothesized that adequate collection of CD34(+) cells may be achieved with lower doses (per kilogram of body weight) of G-CSF in donors with higher BMI compared with donors with lower BMI. Using the Center for International Blood and Marrow Transplant Research database, we evaluated the impact of donor BMI on G-CSF-mobilized PBSC yield in healthy unrelated donors. We examined 20 884 PBSC donations collected at National Marrow Donor Program centers between 2006 and 2016. We found significantly higher collection yields in obese and severely obese donors compared with normal and overweight donors. An increase in average daily G-CSF dose was associated with an increase in stem cell yield in donors with normal or overweight BMI. In contrast, an increase in average daily G-CSF dose beyond 780 mu g per day in obese and 900 mg per day in severely obese donors did not increase cell yield. Pain and toxicities were assessed at baseline, during G-CSF administration, and postcollection. Obesity was associated with higher levels of self-reported donation-related pain and toxicities in the pericollection and early postdonation recovery periods. This study suggests a maximum effective G-CSF dose for PBSC mobilization in obese and severely obese donors, beyond which higher doses of G-CSF add no increased yield.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
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Till lärosätets databas
- Av författaren/redakt...
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Farhadfar, Nosha
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Hsu, Jack W.
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Logan, Brent R.
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Sees, Jennifer A ...
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Chitphakdithai, ...
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Sugrue, Michele ...
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visa fler...
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Abdel-Azim, Hish ...
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Anderlini, Paolo ...
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Bredeson, Christ ...
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Chhabra, Saurabh
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Diaz, Miguel Ang ...
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Ganguly, Siddhar ...
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Hematti, Peiman
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Kamble, Rammurti ...
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Kasow, Kimberly ...
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Lazarus, Hillard ...
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Lynch, Debra Kel ...
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Murthy, Hemant S ...
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Olsson, Richard
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Papari, Mona
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Przepiorka, Donn ...
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Savani, Bipin N.
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Schears, Raquel
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Seo, Sachiko
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Solh, Melhem M.
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Spitzer, Thomas
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Yared, Jean A.
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Pulsipher, Micha ...
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Shah, Nirali N.
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Switzer, Galen E ...
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Confer, Dennis L ...
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Shaw, Bronwen E.
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Wingard, John R.
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Hematologi
- Artiklar i publikationen
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Blood Advances
- Av lärosätet
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Uppsala universitet
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Karolinska Institutet