Effects of inhibitors of the arachidonic acid cascade on primary muscle culture from a Duchenne muscular dystrophy patient

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Fältnamn	Indikatorer	Metadata
000		02833naa a2200337 4500
001		oai:DiVA.org:liu-40845
003		SwePub
008		091010s2007 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-408452 URI
024	7	a https://doi.org/10.1016/j.plefa.2007.10.0022 DOI
040		a (SwePub)liu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Gati, Istvan,d 1954-u Linköpings universitet,Neurologi,Hälsouniversitetet4 aut0 (Swepub:liu)istga26
245	1 0	a Effects of inhibitors of the arachidonic acid cascade on primary muscle culture from a Duchenne muscular dystrophy patient
264	1	b Elsevier BV,c 2007
338		a print2 rdacarrier
520		a The aim of this study was to elucidate the mechanisms of action for potential targets of therapeutic intervention related to the arachidonic acid cascade in muscular dystrophy. Primary cultures from a Duchenne patient were used to study the expression of dystrophin-1, utrophin, desmin, neonatal myosin heavy chain (MHCn) and Bcl-2 during inhibition of phospholipase A2 (PLA2), cyclooxygenase (COX) and lipoxygenase (LOX). Hypo-osmotic treatment was applied in order to trigger Ca2+ influx and PLA2 activity. Inhibition of PLA2 and LOX with prednisolone and nordihydroguaiaretic acid (NDGA) caused a semi-quantitative increase of utrophin and Bcl-2-, and a dose-dependent, quantitative increase of desmin expression, an effect that was augmented by hypo-osmotic treatment. Our results indicate that LOX inhibitors, similarly to corticosteroids, can be beneficial in the treatment of muscular dystrophies. © 2007 Elsevier Ltd. All rights reserved.
653		a MEDICINE
653		a MEDICIN
700	1	a Danielsson, Olof,d 1963-u Linköpings universitet,Neurologi,Hälsouniversitetet4 aut0 (Swepub:liu)oloda25
700	1	a Betmark, T4 aut
700	1	a Ernerudh, Jan,d 1952-u Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Klinisk immunologi,Klinisk immunologi och transfusionsmedicin4 aut0 (Swepub:liu)janer15
700	1	a Öllinger, Karin,d 1962-u Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Patologi,Klinisk patologi och klinisk genetik4 aut0 (Swepub:liu)karol56
700	1	a Dizdar Segrell, Nil,d 1960-u Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Neurologi,Neurologiska kliniken4 aut0 (Swepub:liu)nildi39
710	2	a Linköpings universitetb Neurologi4 org
773	0	t Prostaglandins, Leukotrienes and Essential Fatty Acidsd : Elsevier BVg 77:3-4, s. 217-223q 77:3-4<217-223x 0952-3278x 1532-2823
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-40845
856	4 8	u https://doi.org/10.1016/j.plefa.2007.10.002

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Av författaren/redakt...: Gati, Istvan, 19 ...; Danielsson, Olof ...; Betmark, T; Ernerudh, Jan, 1 ...; Öllinger, Karin, ...; Dizdar Segrell, ...

Artiklar i publikationen: Prostaglandins, ...

Av lärosätet: Linköpings universitet

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