G protein-coupled oestrogen receptor 1 (GPER1)/GPR30: a new player in cardiovascular and metabolic oestrogenic signalling

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Fältnamn	Indikatorer	Metadata
000		03643naa a2200397 4500
001		oai:lup.lub.lu.se:45edea0d-7eb5-45e5-8c42-85b7bd9bee3d
003		SwePub
008		160401s2011 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://lup.lub.lu.se/record/20491932 URI
024	7	a https://doi.org/10.1111/j.1476-5381.2011.01235.x2 DOI
040		a (SwePub)lu
041		a engb eng
042		9 SwePub
072	7	a for2 swepub-publicationtype
072	7	a ref2 swepub-contenttype
100	1	a Nilsson, Bengt-Olofu Lund University,Lunds universitet,Kärlfysiologi,Forskargrupper vid Lunds universitet,Vascular Physiology,Lund University Research Groups4 aut0 (Swepub:lu)mphy-bon
245	1 0	a G protein-coupled oestrogen receptor 1 (GPER1)/GPR30: a new player in cardiovascular and metabolic oestrogenic signalling
264		c 2011-06-27
264	1	b Wiley,c 2011
520		a Oestrogens are important sex hormones central to health and disease in both genders that have protective effects on the cardiovascular and metabolic systems. These hormones act in complex ways via both genomic and non-genomic mechanisms. The genomic mechanisms are relatively well characterized, whereas the non-genomic ones are only beginning to be explored. Two oestrogen receptors (ER), ER alpha and ER beta, have been described that act as nuclear transcription factors but can also associate with the plasma membrane and influence cytosolic signalling. ERa has been shown to mediate both anti-atherogenic effects and pro-survival effects in pancreatic beta-cells. In recent years, a third membrane-bound ER has emerged, G protein-coupled receptor 30 or G protein-coupled oestrogen receptor 1 (GPER1), which mediates oestrogenic responses in cardiovascular and metabolic regulation. Both GPER1 knock-out models and pharmacological agents are now available to study GPER1 function. These tools have revealed that GPER1 activation may have several beneficial effects in the cardiovascular system including vasorelaxation, inhibition of smooth muscle cell proliferation, and protection of the myocardium against ischaemia/reperfusion injury, and in the metabolic system including stimulation of insulin release and protection against pancreatic beta-cell apoptosis. Thus, GPER1 is emerging as a candidate therapeutic target in both cardiovascular and metabolic disease.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Farmakologi och toxikologi0 (SwePub)301022 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Pharmacology and Toxicology0 (SwePub)301022 hsv//eng
653		a G protein-coupled receptor
653		a oestrogen
653		a cardiovascular regulation
653		a metabolic regulation
653		a cellular signalling
653		a non-genomic mechanisms
700	1	a Olde, Björnu Lund University,Lunds universitet,Drug Target Discovery,Forskargrupper vid Lunds universitet,Lund University Research Groups4 aut0 (Swepub:lu)mphy-bol
700	1	a Leeb-Lundberg, Fredriku Lund University,Lunds universitet,Drug Target Discovery,Forskargrupper vid Lunds universitet,Lund University Research Groups4 aut0 (Swepub:lu)mphy-fle
710	2	a Kärlfysiologib Forskargrupper vid Lunds universitet4 org
773	0	t British Journal of Pharmacologyd : Wileyg 163:6, s. 1131-1139q 163:6<1131-1139x 1476-5381x 0007-1188
856	4	u http://dx.doi.org/10.1111/j.1476-5381.2011.01235.xy FULLTEXT
856	4	u https://europepmc.org/articles/pmc3144530?pdf=render
856	4 8	u https://lup.lub.lu.se/record/2049193
856	4 8	u https://doi.org/10.1111/j.1476-5381.2011.01235.x

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