Evidence for eosinophil and IL-17 mediated inflammation in allergic rhinitis

Sökning: L773:1476 7961 > Evidence for eosino...

Amin, KawaUppsala universitet,Lung- allergi- och sömnforskning,Department of Medicine and Microbiology/Immunology, College of Medicine, University of Sulaimani, Sulaimanyah, Iraq (författare)

Background: The aim was to determine the level of inflammatory cytokines, eosinophil cationic protein and IgE in allergic rhinitis (AR) patients.Subjects and methods: Blood samples were taken from 88 AR patients and 88 healthy controls (HC). Each sample was analysed for eosinophil counts by flow cytometry, IgE by ECLIA, ECP, IL-17, and IL-33 by using ELISA test.Results: There was no significant difference between AR patients and the control group in age and gender. Levels of eosinophils, IgE, ECP, IL-17, IL-33 and the total symptom scores were significantly higher in AR patients than the HC (P = 0.0001). Serum ECP correlated with IL-17 (P = 0.041, r = 0.42), IL-33 (P = 0.0001, r = 080), and IgE levels (P = 0.017, r = 0.45) in the R patients. There was no correlation between IL-17 and IL-33. There was a correlation between symptom scores and eosinophils (P = 0.026, r = 0.52), and IgE (P = 0.001, r = 0.60) in the patients. No correlation was observed between symptom scores and ECP, IL-17, and IL-33 in the AR patient.Conclusions: Patients with AR have significant higher serum levels of ECP, IL-17, and IL-33 than healthy controls. This indicates that these markers could be used to in order to diagnose AR and to monitor disease. Inhibitory molecules to IL-17 and IL-33 may be considered as novel treatment strategies.

Issa, Sulaf MosaDepartment of Medicine and Microbiology/Immunology, College of Medicine, University of Sulaimani, Sulaimanyah, Iraq (författare)
Ali, Kosar MohammadDepartment of Medicine and Microbiology/Immunology, College of Medicine, University of Sulaimani, Sulaimanyah, Iraq (författare)
Aziz, Muaid IsmielDepartment of Medicine and Microbiology/Immunology, College of Medicine, University of Sulaimani, Sulaimanyah, Iraq (författare)
Hama Amieen, Huner MohamedOtolaryngology Center, Sulaimani Teaching Hospital, Sulaimanyah, Iraq (författare)
Byström, JonasExpermiental Medicine and Rheumatology, William Harvey Research Institute, Barts & The London, Queen Mary, University of London, Charterhouse Square, London, EC1M 6BQ, UK (författare)
Janson, ChristerUppsala universitet,Lung- allergi- och sömnforskning(Swepub:uu)chrisjn (författare)
Uppsala universitetLung- allergi- och sömnforskning (creator_code:org_t)

Ingår i:Clinical and Molecular Allergy: Springer Science and Business Media LLC181476-7961

Av författaren/redakt...: Amin, Kawa; Issa, Sulaf Mosa; Ali, Kosar Moham ...; Aziz, Muaid Ismi ...; Hama Amieen, Hun ...; Byström, Jonas; visa fler...; Janson, Christer; visa färre...

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