Paralemmin-1, a modulator of filopodia induction is required for spine maturation

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Fältnamn	Indikatorer	Metadata
000		02706naa a2200409 4500
001		oai:DiVA.org:uu-109068
003		SwePub
008		091009s2008 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1090682 URI
024	7	a https://doi.org/10.1091/mbc.E07-08-08022 DOI
040		a (SwePub)uu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Arstikaitis, Pamela4 aut
245	1 0	a Paralemmin-1, a modulator of filopodia induction is required for spine maturation
264	1	b ASCB,c 2008
338		a print2 rdacarrier
520		a Dendritic filopodia are thought to participate in neuronal contact formation and development of dendritic spines, however, molecules that regulate filopodia extension and their maturation to spines remain largely unknown. Here we identify paralemmin-1 as a regulator of filopodia induction and spine maturation. Paralemmin-1 localizes to dendritic membranes, and its ability to induce filopodia and recruit synaptic elements to contact sites requires protein acylation. Effects of paralemmin-1 on synapse maturation are modulated by alternative splicing that regulates spine formation and recruitment of AMPA-type glutamate receptors. Paralemmin-1 enrichment at the plasma membrane is subject to rapid changes in neuronal excitability, and this process controls neuronal activity-driven effects on protrusion expansion. Knockdown of paralemmin-1 in developing neurons reduces the number of filopodia and spines formed and diminishes the effects of Shank1b on the transformation of existing filopodia into spines. Our study identifies a key role for paralemmin-1 in spine maturation through modulation of filopodia induction.
650	7	a NATURVETENSKAPx Biologi0 (SwePub)1062 hsv//swe
650	7	a NATURAL SCIENCESx Biological Sciences0 (SwePub)1062 hsv//eng
653		a Biology
653		a Biologi
700	1	a Gauthier-Campbell, Catherine4 aut
700	1	a Gutierrez Herrera, Rosario Carolina4 aut
700	1	a Huang, Kun4 aut
700	1	a Levinson, Joshua N.4 aut
700	1	a Murphy, Timothy H.4 aut
700	1	a Kilimann, Manfred W.u Uppsala universitet,Molekylär cellbiologi4 aut0 (Swepub:uu)makil021
700	1	a Sala, Carlo4 aut
700	1	a Colicos, Michael A.4 aut
700	1	a El-Husseini, Alaa4 aut
710	2	a Uppsala universitetb Molekylär cellbiologi4 org
773	0	t Molecular Biology of the Celld : ASCBg 19:5, s. 2026-2038q 19:5<2026-2038x 1059-1524x 1939-4586
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-109068
856	4 8	u https://doi.org/10.1091/mbc.E07-08-0802

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Av författaren/redakt...: Arstikaitis, Pam ...; Gauthier-Campbel ...; Gutierrez Herrer ...; Huang, Kun; Levinson, Joshua ...; Murphy, Timothy ...; visa fler...; Kilimann, Manfre ...; Sala, Carlo; Colicos, Michael ...; El-Husseini, Ala ...; visa färre...

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Av lärosätet: Uppsala universitet

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