Sökning: L773:1939 4586 > Paralemmin-1, a mod...
Fältnamn | Indikatorer | Metadata |
---|---|---|
000 | 02706naa a2200409 4500 | |
001 | oai:DiVA.org:uu-109068 | |
003 | SwePub | |
008 | 091009s2008 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1090682 URI |
024 | 7 | a https://doi.org/10.1091/mbc.E07-08-08022 DOI |
040 | a (SwePub)uu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Arstikaitis, Pamela4 aut |
245 | 1 0 | a Paralemmin-1, a modulator of filopodia induction is required for spine maturation |
264 | 1 | b ASCB,c 2008 |
338 | a print2 rdacarrier | |
520 | a Dendritic filopodia are thought to participate in neuronal contact formation and development of dendritic spines, however, molecules that regulate filopodia extension and their maturation to spines remain largely unknown. Here we identify paralemmin-1 as a regulator of filopodia induction and spine maturation. Paralemmin-1 localizes to dendritic membranes, and its ability to induce filopodia and recruit synaptic elements to contact sites requires protein acylation. Effects of paralemmin-1 on synapse maturation are modulated by alternative splicing that regulates spine formation and recruitment of AMPA-type glutamate receptors. Paralemmin-1 enrichment at the plasma membrane is subject to rapid changes in neuronal excitability, and this process controls neuronal activity-driven effects on protrusion expansion. Knockdown of paralemmin-1 in developing neurons reduces the number of filopodia and spines formed and diminishes the effects of Shank1b on the transformation of existing filopodia into spines. Our study identifies a key role for paralemmin-1 in spine maturation through modulation of filopodia induction. | |
650 | 7 | a NATURVETENSKAPx Biologi0 (SwePub)1062 hsv//swe |
650 | 7 | a NATURAL SCIENCESx Biological Sciences0 (SwePub)1062 hsv//eng |
653 | a Biology | |
653 | a Biologi | |
700 | 1 | a Gauthier-Campbell, Catherine4 aut |
700 | 1 | a Gutierrez Herrera, Rosario Carolina4 aut |
700 | 1 | a Huang, Kun4 aut |
700 | 1 | a Levinson, Joshua N.4 aut |
700 | 1 | a Murphy, Timothy H.4 aut |
700 | 1 | a Kilimann, Manfred W.u Uppsala universitet,Molekylär cellbiologi4 aut0 (Swepub:uu)makil021 |
700 | 1 | a Sala, Carlo4 aut |
700 | 1 | a Colicos, Michael A.4 aut |
700 | 1 | a El-Husseini, Alaa4 aut |
710 | 2 | a Uppsala universitetb Molekylär cellbiologi4 org |
773 | 0 | t Molecular Biology of the Celld : ASCBg 19:5, s. 2026-2038q 19:5<2026-2038x 1059-1524x 1939-4586 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-109068 |
856 | 4 8 | u https://doi.org/10.1091/mbc.E07-08-0802 |
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