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Sökning: L773:2198 3844 OR L773:2198 3844 > (2022) > Embedded 3D Printin...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004854naa a2200469 4500
001oai:lup.lub.lu.se:531e830e-8b2f-4bad-8d1c-7620e54ad790
003SwePub
008220802s2022 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/531e830e-8b2f-4bad-8d1c-7620e54ad7902 URI
0247 a https://doi.org/10.1002/advs.2022013922 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Kajtez, Jankou Lund University,Lunds universitet,Utvecklings- och regenerativ neurobiologi,Forskargrupper vid Lunds universitet,Developmental and Regenerative Neurobiology,Lund University Research Groups,Wallenberg Neuroscience Center,Technical University of Denmark4 aut0 (Swepub:lu)ja1386ka
2451 0a Embedded 3D Printing in Self-Healing Annealable Composites for Precise Patterning of Functionally Mature Human Neural Constructs
264 c 2022-06-16
264 1b Wiley,c 2022
520 a Human in vitro models of neural tissue with tunable microenvironment and defined spatial arrangement are needed to facilitate studies of brain development and disease. Towards this end, embedded printing inside granular gels holds great promise as it allows precise patterning of extremely soft tissue constructs. However, granular printing support formulations are restricted to only a handful of materials. Therefore, there has been a need for novel materials that take advantage of versatile biomimicry of bulk hydrogels while providing high-fidelity support for embedded printing akin to granular gels. To address this need, Authors present a modular platform for bioengineering of neuronal networks via direct embedded 3D printing of human stem cells inside Self-Healing Annealable Particle-Extracellular matrix (SHAPE) composites. SHAPE composites consist of soft microgels immersed in viscous extracellular-matrix solution to enable precise and programmable patterning of human stem cells and consequent generation mature subtype-specific neurons that extend projections into the volume of the annealed support. The developed approach further allows multi-ink deposition, live spatial and temporal monitoring of oxygen levels, as well as creation of vascular-like channels. Due to its modularity and versatility, SHAPE biomanufacturing toolbox has potential to be used in applications beyond functional modeling of mechanically sensitive neural constructs.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng
650 7a TEKNIK OCH TEKNOLOGIERx Annan teknik0 (SwePub)2112 hsv//swe
650 7a ENGINEERING AND TECHNOLOGYx Other Engineering and Technologies0 (SwePub)2112 hsv//eng
7001 a Wesseler, Milan Finnu Technical University of Denmark4 aut
7001 a Birtele, Marcellau Lund University,Lunds universitet,Utvecklings- och regenerativ neurobiologi,Forskargrupper vid Lunds universitet,Developmental and Regenerative Neurobiology,Lund University Research Groups4 aut0 (Swepub:lu)ma5203bi
7001 a Khorasgani, Farinaz Riyahiu Technical University of Denmark4 aut
7001 a Rylander Ottosson, Daniellau Lund University,Lunds universitet,Regenerativ neurofysiologi,Forskargrupper vid Lunds universitet,Regenerative Neurophysiology,Lund University Research Groups4 aut0 (Swepub:lu)med-drr
7001 a Heiskanen, Artou Technical University of Denmark4 aut0 (Swepub:lu)anal-ahe
7001 a Kamperman, Tomu University of Twente4 aut
7001 a Leijten, Jeroenu University of Twente4 aut
7001 a Martínez-Serrano, Albertou Autonomous University of Madrid,CSIC Center of Molecular Biology Severo Ochoa (UAM)4 aut
7001 a Larsen, Niels Bu Technical University of Denmark4 aut
7001 a Angelini, Thomas Eu University of Florida4 aut
7001 a Parmar, Malinu Lund University,Lunds universitet,Utvecklings- och regenerativ neurobiologi,Forskargrupper vid Lunds universitet,Developmental and Regenerative Neurobiology,Lund University Research Groups,Wallenberg Neuroscience Center4 aut0 (Swepub:lu)mphy-mpa
7001 a Lind, Johan Uu Technical University of Denmark4 aut0 (Swepub:lu)uvet-jol
7001 a Emnéus, Jennyu Technical University of Denmark4 aut0 (Swepub:lu)je5703em
7102 a Utvecklings- och regenerativ neurobiologib Forskargrupper vid Lunds universitet4 org
7730 t Advanced science (Weinheim, Baden-Wurttemberg, Germany)d : Wileyg 9:25q 9:25x 2198-3844
8564 u http://dx.doi.org/10.1002/advs.202201392x freey FULLTEXT
8564 8u https://lup.lub.lu.se/record/531e830e-8b2f-4bad-8d1c-7620e54ad790
8564 8u https://doi.org/10.1002/advs.202201392

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