Sökning: WFRF:(Abrahmsén Alami Susanna) > A mechanistic model...
Fältnamn | Indikatorer | Metadata |
---|---|---|
000 | 04177naa a2200577 4500 | |
001 | oai:research.chalmers.se:6d7fb1fd-f2d0-4ba0-8cba-73a3a1038c76 | |
003 | SwePub | |
008 | 171008s2010 | |||||||||||000 ||eng| | |
009 | oai:lup.lub.lu.se:514df704-6119-49e6-af93-5519c5cf7e40 | |
024 | 7 | a https://research.chalmers.se/publication/1292222 URI |
024 | 7 | a https://doi.org/10.1016/j.jconrel.2010.07.1022 DOI |
024 | 7 | a https://lup.lub.lu.se/record/16447092 URI |
040 | a (SwePub)cthd (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Kaunisto, Eriku Lund University,Lunds universitet,Avdelningen för kemiteknik,Institutionen för processteknik och tillämpad biovetenskap,Institutioner vid LTH,Lunds Tekniska Högskola,Division of Chemical Engineering,Department of Process and Life Science Engineering,Departments at LTH,Faculty of Engineering, LTH4 aut0 (Swepub:lu)chem-erk |
245 | 1 0 | a A mechanistic modelling approach to polymer dissolution using magnetic resonance microimaging |
264 | 1 | b Elsevier BV,c 2010 |
520 | a In this paper a computationally efficient mathematical model describing the swelling and dissolution of a polyethylene oxide tablet is presented. The model was calibrated against polymer release, front position and water concentration profile data inside the gel layer, using two different diffusion models. The water concentration profiles were obtained from magnetic resonance microimaging data which, in addition to the previously used texture analysis method, can help to validate and discriminate between the mechanisms of swelling, diffusion and erosion in relation to the dissolution process. Critical parameters were identified through a comprehensive sensitivity analysis, and the effect of hydrodynamic shearing was investigated by using two different stirring rates. Good agreement was obtained between the experimental results and the model. (C) 2010 Elsevier B.V. All rights reserved. | |
650 | 7 | a NATURVETENSKAPx Kemi0 (SwePub)1042 hsv//swe |
650 | 7 | a NATURAL SCIENCESx Chemical Sciences0 (SwePub)1042 hsv//eng |
650 | 7 | a TEKNIK OCH TEKNOLOGIERx Kemiteknik0 (SwePub)2042 hsv//swe |
650 | 7 | a ENGINEERING AND TECHNOLOGYx Chemical Engineering0 (SwePub)2042 hsv//eng |
653 | a ALE | |
653 | a erosion | |
653 | a glassy-polymers | |
653 | a Dissolution | |
653 | a reptation | |
653 | a Mathematical modelling | |
653 | a MRI | |
653 | a poly(ethylene oxide) | |
653 | a drug-delivery | |
653 | a hpmc matrices | |
653 | a mathematical-models | |
653 | a release | |
653 | a Polyethylene oxide | |
653 | a diffusion | |
653 | a rubbery | |
700 | 1 | a Abrahmsén-Alami, Susannau AstraZeneca AB4 aut |
700 | 1 | a Borgquist, P.4 aut |
700 | 1 | a Larsson, Anette,d 1966u Chalmers tekniska högskola,Chalmers University of Technology4 aut0 (Swepub:cth)anettel |
700 | 1 | a Nilsson, Berntu Lund University,Lunds universitet,Avdelningen för kemiteknik,Institutionen för processteknik och tillämpad biovetenskap,Institutioner vid LTH,Lunds Tekniska Högskola,Division of Chemical Engineering,Department of Process and Life Science Engineering,Departments at LTH,Faculty of Engineering, LTH4 aut0 (Swepub:lu)kat-bni |
700 | 1 | a Axelsson, Andersu Lund University,Lunds universitet,Avdelningen för kemiteknik,Institutionen för processteknik och tillämpad biovetenskap,Institutioner vid LTH,Lunds Tekniska Högskola,Division of Chemical Engineering,Department of Process and Life Science Engineering,Departments at LTH,Faculty of Engineering, LTH4 aut0 (Swepub:lu)kat-aax |
710 | 2 | a Avdelningen för kemiteknikb Institutionen för processteknik och tillämpad biovetenskap4 org |
773 | 0 | t Journal of Controlled Released : Elsevier BVg 147:2, s. 232-241q 147:2<232-241x 0168-3659x 1873-4995 |
856 | 4 | u http://dx.doi.org/10.1016/j.jconrel.2010.07.102y FULLTEXT |
856 | 4 8 | u https://research.chalmers.se/publication/129222 |
856 | 4 8 | u https://doi.org/10.1016/j.jconrel.2010.07.102 |
856 | 4 8 | u https://lup.lub.lu.se/record/1644709 |
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