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MRI analysis of dif...
MRI analysis of diffuse axonal injury - Hemorrhagic lesions in the mesencephalon idicate poor long-term outcome
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- Abu Hamdeh, Sami (författare)
- Uppsala universitet,Neurokirurgi
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- Marklund, Niklas (författare)
- Uppsala universitet,Neurokirurgi
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- Lannsjö, Marianne (författare)
- Uppsala universitet,Rehabiliteringsmedicin
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- Howells, Tim (författare)
- Uppsala universitet,Neurokirurgi
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- Raininko, Raili (författare)
- Uppsala universitet,Radiologi
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- Wikström, Johan (författare)
- Uppsala universitet,Radiologi
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- Enblad, Per (författare)
- Uppsala universitet,Neurokirurgi
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(creator_code:org_t)
- Springer, 2016
- 2016
- Engelska.
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Ingår i: MRI analysis of diffuse axonal injury - Hemorrhagic lesions in the mesencephalon idicate poor long-term outcome. - : Springer.
- Relaterad länk:
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https://urn.kb.se/re...
Abstract
Ämnesord
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- Purpose: Clinical outcome after traumatic diffuse axonal injury (DAI) is difficult to predict. Three MRI techniques were compared in demonstrating acute brain lesions. Relationship of the anatomical distribution of the lesions in combination with clinical prognostic factors to outcome after 6 months was evaluated. Methods and Materials: Thirty patients, aged 16-60 years (mean 31.2 years) with severe DAI (Glasgow Motor Score = GMS < 6) were examined with MRI at 1.5T within one week after the injury. A diffusion-weighted (DW) sequence (SE-EPI, b value 1000 s/mm2), a T2*-weighted gradient echo (T2*GRE) sequence and a susceptibility-weighted (SWI) sequence were evaluated by two independent reviewers with short and long neuroradiological experiences. Clinical outcome was assessed with Extended Glasgow Outcome Score (GOSE) after ≥ 6 months.Results: Interreviewer agreement for DAI classification was very good (ҡ 0.82 – 0.91) with all three sequences. SWI visualized more lesions than the T2*GRE or DW sequence. In univariate analysis, number of DW lesions in the deep gray matter area including the internal capsules, number of SWI lesions in the mesencephalon, age, and GMS at admission and discharge correlated significantly with poor outcome. Multivariate analysis only revealed an independent relation with poor outcome for age (p = 0.011) and lesions in the mesencephalic region including crura cerebri, substantia nigra and tegmentum on SWI (p = 0.032).Conclusion: SWI is the most sensitive technique to visualize lesions in DAI. Age over 30 years and hemorrhagic mesencephalic lesions anterior to the tectum are indicators of poor long-term outcome in DAI.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
Nyckelord
- Radiologi
- Radiology
Publikations- och innehållstyp
- ref (ämneskategori)
- kon (ämneskategori)