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  • Berron, DavidLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,LU profilområde: Proaktivt åldrande,Lunds universitets profilområden,Clinical Memory Research,Lund University Research Groups,LU Profile Area: Proactive Ageing,Lund University Profile areas,neotiv GmbH,German Center for Neurodegenerative Diseases (DZNE) Magdeburg (författare)

A remote digital memory composite to detect cognitive impairment in memory clinic samples in unsupervised settings using mobile devices

  • Artikel/kapitelEngelska2024

Förlag, utgivningsår, omfång ...

  • 2024

Nummerbeteckningar

  • LIBRIS-ID:oai:lup.lub.lu.se:ae228c8b-7a17-44d9-b7ca-eeb01ff9a7d1
  • https://lup.lub.lu.se/record/ae228c8b-7a17-44d9-b7ca-eeb01ff9a7d1URI
  • https://doi.org/10.1038/s41746-024-00999-9DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

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Klassifikation

  • Ämneskategori:art swepub-publicationtype
  • Ämneskategori:ref swepub-contenttype

Anmärkningar

  • Remote monitoring of cognition holds the promise to facilitate case-finding in clinical care and the individual detection of cognitive impairment in clinical and research settings. In the context of Alzheimer’s disease, this is particularly relevant for patients who seek medical advice due to memory problems. Here, we develop a remote digital memory composite (RDMC) score from an unsupervised remote cognitive assessment battery focused on episodic memory and long-term recall and assess its construct validity, retest reliability, and diagnostic accuracy when predicting MCI-grade impairment in a memory clinic sample and healthy controls. A total of 199 participants were recruited from three cohorts and included as healthy controls (n = 97), individuals with subjective cognitive decline (n = 59), or patients with mild cognitive impairment (n = 43). Participants performed cognitive assessments in a fully remote and unsupervised setting via a smartphone app. The derived RDMC score is significantly correlated with the PACC5 score across participants and demonstrates good retest reliability. Diagnostic accuracy for discriminating memory impairment from no impairment is high (cross-validated AUC = 0.83, 95% CI [0.66, 0.99]) with a sensitivity of 0.82 and a specificity of 0.72. Thus, unsupervised remote cognitive assessments implemented in the neotiv digital platform show good discrimination between cognitively impaired and unimpaired individuals, further demonstrating that it is feasible to complement the neuropsychological assessment of episodic memory with unsupervised and remote assessments on mobile devices. This contributes to recent efforts to implement remote assessment of episodic memory for case-finding and monitoring in large research studies and clinical care.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Glanz, WenzelOtto von Guericke University Magdeburg (författare)
  • Clark, LindsayUniversity of Wisconsin-Madison (författare)
  • Basche, KristinUniversity of Wisconsin-Madison (författare)
  • Grande, XeniaOtto von Guericke University Magdeburg (författare)
  • Güsten, JeremieOtto von Guericke University Magdeburg,German Center for Neurodegenerative Diseases (DZNE), Bonn (författare)
  • Billette, Ornella V.neotiv GmbH (författare)
  • Hempen, Inaneotiv GmbH (författare)
  • Naveed, Muhammad Hashimneotiv GmbH (författare)
  • Diersch, Nadineneotiv GmbH (författare)
  • Butryn, MichaelaGerman Center for Neurodegenerative Diseases (DZNE), Bonn,Otto von Guericke University Magdeburg (författare)
  • Spottke, AnnikaGerman Center for Neurodegenerative Diseases (DZNE), Bonn (författare)
  • Buerger, KatharinaUniversity Hospital Munich,German Center for Neurodegenerative Diseases (DZNE), Bonn (författare)
  • Perneczky, RobertGerman Center for Neurodegenerative Diseases (DZNE), Bonn,Munich Cluster for Systems Neurology,Imperial College London,University Hospital Munich (författare)
  • Schneider, AnjaGerman Center for Neurodegenerative Diseases (DZNE), Bonn,University Hospital Bonn (författare)
  • Teipel, StefanGerman Center for Neurodegenerative Diseases (DZNE), Bonn,Universitätsmedizin Rostock (författare)
  • Wiltfang, JensGerman Center for Neurodegenerative Diseases (DZNE), Bonn,University Medical Center Göttingen (författare)
  • Johnson, SterlingUniversity of Wisconsin-Madison (författare)
  • Wagner, MichaelUniversity Hospital Bonn,German Center for Neurodegenerative Diseases (DZNE), Bonn (författare)
  • Jessen, FrankGerman Center for Neurodegenerative Diseases (DZNE), Bonn (författare)
  • Düzel, EmrahGerman Center for Neurodegenerative Diseases (DZNE), Bonn,Otto von Guericke University Magdeburg (författare)
  • Klinisk minnesforskningForskargrupper vid Lunds universitet (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:npj Digital Medicine7:12398-6352

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