Amyloid-β PET and CSF in an autopsy-confirmed cohort

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Sökning: WFRF:(Bouwman Femke) > Amyloid-β PET and C...

LIBRIS Formathandbok (Information om MARC21)

Fältnamn	Indikatorer	Metadata
000		04313naa a2200409 4500
001		oai:lup.lub.lu.se:37bec1ff-2e71-460d-88a5-2ca8b9fb4d79
003		SwePub
008		201112s2020 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://lup.lub.lu.se/record/37bec1ff-2e71-460d-88a5-2ca8b9fb4d792 URI
024	7	a https://doi.org/10.1002/acn3.511952 DOI
040		a (SwePub)lu
041		a engb eng
042		9 SwePub
072	7	a art2 swepub-publicationtype
072	7	a ref2 swepub-contenttype
100	1	a Reimand, Juhanu North Estonia Medical Centre,Amsterdam UMC - Vrije Universiteit Amsterdam,Tallinn University of Technology,Vrije Universiteit Amsterdam4 aut
245	1 0	a Amyloid-β PET and CSF in an autopsy-confirmed cohort
264		c 2020-10-20
264	1	b Wiley,c 2020
300		a 11 s.
520		a Objective: Accumulation of amyloid-β is among the earliest changes in Alzheimer’s disease (AD). Amyloid-β positron emission tomography (PET) and Aβ42 in cerebrospinal fluid (CSF) both assess amyloid-β pathology in-vivo, but 10–20% of cases show discordant (CSF+/PET− or CSF-/PET+) results. The neuropathological correspondence with amyloid-β CSF/PET discordance is unknown. Methods: We included 21 patients from our tertiary memory clinic who had undergone both CSF Aβ42 analysis and amyloid-β PET, and had neuropathological data available. Amyloid-β PET and CSF results were compared with neuropathological ABC scores (comprising of Thal (A), Braak (B), and CERAD (C) stage, all ranging from 0 [low] to 3 [high]) and neuropathological diagnosis. Results: Neuropathological diagnosis was AD in 11 (52%) patients. Amyloid-β PET was positive in all A3, C2, and C3 cases and in one of the two A2 cases. CSF Aβ42 was positive in 92% of ≥A2 and 90% of ≥C2 cases. PET and CSF were discordant in three of 21 (14%) cases: CSF+/PET− in a patient with granulomatosis with polyangiitis (A0B0C0), CSF+/PET− in a patient with FTLD-TDP type B (A2B1C1), and CSF-/PET+ in a patient with AD (A3B3C3). Two CSF+/PET+ cases had a non-AD neuropathological diagnosis, that is FTLD-TDP type E (A3B1C1) and adult-onset leukoencephalopathy with axonal spheroids (A1B1C0). Interpretation: Our study demonstrates neuropathological underpinnings of amyloid-β CSF/PET discordance. Furthermore, amyloid-β biomarker positivity on both PET and CSF did not invariably result in an AD diagnosis at autopsy, illustrating the importance of considering relevant comorbidities when evaluating amyloid-β biomarker results.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng
700	1	a Boon, Baayla D.C.u Amsterdam UMC - Vrije Universiteit Amsterdam,Vrije Universiteit Amsterdam4 aut
700	1	a Collij, Lyduine E.u Amsterdam UMC - Vrije Universiteit Amsterdam,Vrije Universiteit Amsterdam4 aut
700	1	a Teunissen, Charlotte E.u Vrije Universiteit Amsterdam,Amsterdam UMC - Vrije Universiteit Amsterdam4 aut
700	1	a Rozemuller, Annemieke J.M.u Amsterdam UMC - Vrije Universiteit Amsterdam,Vrije Universiteit Amsterdam4 aut
700	1	a van Berckel, Bart N.M.u Vrije Universiteit Amsterdam,Amsterdam UMC - Vrije Universiteit Amsterdam4 aut
700	1	a Scheltens, Philipu Amsterdam UMC - Vrije Universiteit Amsterdam,Vrije Universiteit Amsterdam4 aut
700	1	a Ossenkoppele, Riku Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Amsterdam UMC - Vrije Universiteit Amsterdam,Vrije Universiteit Amsterdam4 aut0 (Swepub:lu)ri1513os
700	1	a Bouwman, Femkeu Amsterdam UMC - Vrije Universiteit Amsterdam,Vrije Universiteit Amsterdam4 aut
710	2	a North Estonia Medical Centreb Amsterdam UMC - Vrije Universiteit Amsterdam4 org
773	0	t Annals of Clinical and Translational Neurologyd : Wileyg 7:11, s. 2150-2160q 7:11<2150-2160x 2328-9503
856	4	u http://dx.doi.org/10.1002/acn3.51195x freey FULLTEXT
856	4	u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/acn3.51195
856	4 8	u https://lup.lub.lu.se/record/37bec1ff-2e71-460d-88a5-2ca8b9fb4d79
856	4 8	u https://doi.org/10.1002/acn3.51195

Hitta via bibliotek

Annals of Clinical and Translational Neurology (Sök värdpublikationen i LIBRIS)

Till lärosätets databas

Hitta mer i SwePub

Av författaren/redakt...: Reimand, Juhan; Boon, Baayla D.C ...; Collij, Lyduine ...; Teunissen, Charl ...; Rozemuller, Anne ...; van Berckel, Bar ...; visa fler...; Scheltens, Phili ...; Ossenkoppele, Ri ...; Bouwman, Femke; visa färre...

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Neurologi

Artiklar i publikationen: Annals of Clinic ...

Av lärosätet: Lunds universitet

Sök utanför SwePub

Sök vidare i:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se