Low-dose oral ketamine as a procedural analgesia in pediatric cancer patients undergoing bone marrow aspirations at a resource-limited cancer hospital in India

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Sökning: WFRF:(Brun Eva) > (2015-2019) > Low-dose oral ketam...

Rayala, SpandanaMNJ Institute of Oncology and Regional Cancer Center (författare)

Low-dose oral ketamine as a procedural analgesia in pediatric cancer patients undergoing bone marrow aspirations at a resource-limited cancer hospital in India

Artikel/kapitelEngelska2019

Förlag, utgivningsår, omfång ...

2019
7 s.

Nummerbeteckningar

LIBRIS-ID:oai:lup.lub.lu.se:ee42ea24-3b0e-451c-824d-ed9553da0f16
https://lup.lub.lu.se/record/ee42ea24-3b0e-451c-824d-ed9553da0f16URI
https://doi.org/10.4103/IJPC.IJPC_110_19DOI

Kompletterande språkuppgifter

Språk:engelska
Sammanfattning på:engelska

Ingår i deldatabas

SwePubSwePub

Klassifikation

Ämneskategori:art swepub-publicationtype
Ämneskategori:ref swepub-contenttype

Anmärkningar

Aim: Many pediatric cancer patients undergo repeated bone marrow aspirations (BMAs) for diagnostic and treatment evaluation purposes. Full anesthesia is the standard of care during this procedure in high-income countries. At hospitals with low resources in low/middle-income countries many children undergo these painful procedures without sufficient pain relief. This study aimed to evaluate the usefulness of low-dose oral ketamine as a procedural analgesic in a low-resource pediatric cancer care department. Materials and Methods: Pediatric patients, 4-15 years of age, who underwent BMAs between September 31 and November 30, 2018, were invited to participate. The study was designed as a placebo-controlled, single-blinded trial with three trial groups. Group K received 1.0 mg/kg of ketamine and Group KM received 1.0 mg/kg ketamine with an addition of 0.2 mg/kg midazolam, mixed in juice 30 min before procedures. Group P received placebo consisting of plain juice. All three groups also received the hospital's current standard treatment for procedural pain in BMAs. Patients and caregivers assessed the procedural pain, as did the performing doctors. For the patients, Faces Pain Scale - Revised was used and the Numeric Rating Scale-11 for caregivers and doctors. Results: A total of 87 patients were included in the study distributed with 29 in Group K, 29 in Group KM, and 29 in Group P. Seven patients were excluded, one patient denied participation and the remaining did not meet the inclusion criteria. There was no significant difference between the pain reported by the groups. A total of 69% patients in Group KM and 35% in Group K had somnolence reported as a side effect compared to 14% in Group P. Conclusion: We found no significant effects on the procedural pain in any of the treatment groups compared to placebo. There were only mild side effects. The doses of ketamine might be insufficient for this painful and stressful procedure.

Ämnesord och genrebeteckningar

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Cancer och onkologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Cancer and Oncology hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Pediatrik hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Pediatrics hsv//eng
Low-dose oral ketamine
pediatric cancer
procedural analgesia

Biuppslag (personer, institutioner, konferenser, titlar ...)

Kyander, MelkerLund University (författare)
Haridass, VikranthMNJ Institute of Oncology and Regional Cancer Center (författare)
Palat, GayatriMNJ Institute of Oncology and Regional Cancer Center (författare)
Ström, AxelSkåne University Hospital (författare)
Wiebe, ThomasLund University,Lunds universitet,Sena effekter efter barncancerbehandling,Forskargrupper vid Lunds universitet,Late effects after childhood cancer treatment,Lund University Research Groups(Swepub:lu)pedi-twi (författare)
Brun, EvaLund University,Lunds universitet,Huvud- och halscancergruppen,Forskargrupper vid Lunds universitet,Head and Neck Cancer Research Group,Lund University Research Groups,Skåne University Hospital(Swepub:lu)onk-ebr (författare)
Segerlantz, MikaelLund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Palliativt Utvecklingscentrum,Forskargrupper vid Lunds universitet,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,The Institute for Palliative Care,Lund University Research Groups,Region Skåne(Swepub:lu)mi8756se (författare)
MNJ Institute of Oncology and Regional Cancer CenterLund University (creator_code:org_t)

Sammanhörande titlar

Ingår i:Indian Journal of Palliative Care25:4, s. 501-5070973-1075

Internetlänk

Hitta via bibliotek

Indian Journal of Palliative Care (Sök värdpublikationen i LIBRIS)

Till lärosätets databas

Hitta mer i SwePub

Av författaren/redakt...: Rayala, Spandana; Kyander, Melker; Haridass, Vikran ...; Palat, Gayatri; Ström, Axel; Wiebe, Thomas; visa fler...; Brun, Eva; Segerlantz, Mika ...; visa färre...

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Cancer och onkol ...

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Pediatrik

Artiklar i publikationen: Indian Journal o ...

Av lärosätet: Lunds universitet

Sök utanför SwePub

Sök vidare i:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se