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High Levels of FGF11 Correlate with Poor Survival in Patients with Human Papillomavirus (HPV)-Positive Oropharyngeal Squamous Cell Carcinoma

de Flon, Caroline Haglund (författare)
Karolinska Inst, Karolinska Univ Hosp, Dept Oncol Pathol, Bioclin J6 20, S-17164 Stockholm, Sweden.;Karolinska Univ Hosp, Dept Clin Pathol, CCK R8 02, S-17164 Stockholm, Sweden.,Department of Oncology-Pathology, Karolinska Institutet, Bioclinicum J6:20, Karolinska University Hospital, 171 64 Stockholm, Sweden;Department of Clinical Pathology, CCK R8:02, Karolinska University Hospital, 171 64 Stockholm, Sweden
Haeggblom, Linnea (författare)
Karolinska Inst, Karolinska Univ Hosp, Dept Oncol Pathol, Bioclin J6 20, S-17164 Stockholm, Sweden.,Department of Oncology-Pathology, Karolinska Institutet, Bioclinicum J6:20, Karolinska University Hospital, 171 64 Stockholm, Sweden
Holzhauser, Stefan (författare)
Karolinska Institutet,Karolinska Inst, Karolinska Univ Hosp, Dept Oncol Pathol, Bioclin J6 20, S-17164 Stockholm, Sweden.,Department of Oncology-Pathology, Karolinska Institutet, Bioclinicum J6:20, Karolinska University Hospital, 171 64 Stockholm, Sweden
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Kostopoulou, Ourania N. (författare)
Karolinska Institutet,Karolinska Inst, Karolinska Univ Hosp, Dept Oncol Pathol, Bioclin J6 20, S-17164 Stockholm, Sweden.,Department of Oncology-Pathology, Karolinska Institutet, Bioclinicum J6:20, Karolinska University Hospital, 171 64 Stockholm, Sweden
Zupancic, Mark (författare)
Karolinska Institutet,Karolinska Inst, Karolinska Univ Hosp, Dept Oncol Pathol, Bioclin J6 20, S-17164 Stockholm, Sweden.;Karolinska Univ Hosp, Dept Head & Neck Surg, Med Unit Head Neck Lung & Skin Canc, S-17164 Stockholm, Sweden.,Department of Oncology-Pathology, Karolinska Institutet, Bioclinicum J6:20, Karolinska University Hospital, 171 64 Stockholm, Sweden;Medical Unit Head Neck Lung and Skin Cancer, Department of Head and Neck Surgery, Karolinska University Hospital, 171 64 Stockholm, Sweden
Dalianis, Tina (författare)
Karolinska Institutet,Karolinska Inst, Karolinska Univ Hosp, Dept Oncol Pathol, Bioclin J6 20, S-17164 Stockholm, Sweden.;Karolinska Univ Hosp, Dept Head & Neck Surg, Med Unit Head Neck Lung & Skin Canc, S-17164 Stockholm, Sweden.,Department of Oncology-Pathology, Karolinska Institutet, Bioclinicum J6:20, Karolinska University Hospital, 171 64 Stockholm, Sweden;Medical Unit Head Neck Lung and Skin Cancer, Department of Head and Neck Surgery, Karolinska University Hospital, 171 64 Stockholm, Sweden
Munck-Wikland, Eva (författare)
Karolinska Univ Hosp, Dept Head & Neck Surg, Med Unit Head Neck Lung & Skin Canc, S-17164 Stockholm, Sweden.;Karolinska Inst, Univ Hosp, Dept Clin Sci Intervent & Technol CLINTEC, Div Ear Nose & Throat Dis, S-17164 Stockholm, Sweden.,Medical Unit Head Neck Lung and Skin Cancer, Department of Head and Neck Surgery, Karolinska University Hospital, 171 64 Stockholm, Sweden;Department of Clinical Science, Intervention and Technology—CLINTEC Division of Ear, Nose and Throat Diseases, Karolinska Institutet, University Hospital, 171 64 Stockholm, Sweden
Marklund, Linda (författare)
Karolinska Institutet,Uppsala universitet,Öron-, näs- och halssjukdomar,Karolinska Univ Hosp, Dept Head & Neck Surg, Med Unit Head Neck Lung & Skin Canc, S-17164 Stockholm, Sweden.;Karolinska Inst, Univ Hosp, Dept Clin Sci Intervent & Technol CLINTEC, Div Ear Nose & Throat Dis, S-17164 Stockholm, Sweden.,Medical Unit Head Neck Lung and Skin Cancer, Department of Head and Neck Surgery, Karolinska University Hospital, 171 64 Stockholm, Sweden;Department of Clinical Science, Intervention and Technology—CLINTEC Division of Ear, Nose and Throat Diseases, Karolinska Institutet, University Hospital, 171 64 Stockholm, Sweden;Department of Surgical Sciences, Section of Otolaryngology and Head and Neck Surgery, Uppsala University, 751 05 Uppsala, Sweden
Nasman, Anders (författare)
Karolinska Institutet,Karolinska Inst, Karolinska Univ Hosp, Dept Oncol Pathol, Bioclin J6 20, S-17164 Stockholm, Sweden.;Karolinska Univ Hosp, Dept Clin Pathol, CCK R8 02, S-17164 Stockholm, Sweden.,Department of Oncology-Pathology, Karolinska Institutet, Bioclinicum J6:20, Karolinska University Hospital, 171 64 Stockholm, Sweden;Department of Clinical Pathology, CCK R8:02, Karolinska University Hospital, 171 64 Stockholm, Sweden
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Karolinska Inst, Karolinska Univ Hosp, Dept Oncol Pathol, Bioclin J6 20, S-17164 Stockholm, Sweden;Karolinska Univ Hosp, Dept Clin Pathol, CCK R8 02, S-17164 Stockholm, Sweden. Department of Oncology-Pathology, Karolinska Institutet, Bioclinicum J6:20, Karolinska University Hospital, 171 64 Stockholm, Sweden;Department of Clinical Pathology, CCK R8:02, Karolinska University Hospital, 171 64 Stockholm, Sweden (creator_code:org_t)
2023-03-24
2023
Engelska.
Ingår i: Cancers. - : MDPI. - 2072-6694. ; 15:7
Relaterad länk:
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https://doi.org/10.3...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • To better identify patients with human papillomavirus (HPV)-positive oropharyngeal cancer (OPSCC) and a poor prognosis after treatment, we compared the gene expression in tumours from patients with a poor or a favourable prognosis in a case-control setting. The results were thereafter validated in two separate cohorts on the RNA and protein levels. High RNA or protein expression of FGF11 was correlated with a poor patient survival in all three cohorts. Taken together, the data imply that FGF11 may play a major role in the prognosis of patients and that FGF11 could serve as a prognostic marker in HPV-positive oropharyngeal cancer.Human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinoma (OPSCC) is associated with a favourable prognosis. It has therefore been suggested that treatment should be individualized and separated by HPV status. However, additional prognostic markers are still needed before treatment can be individualized for this patient group. For this purpose, all patients diagnosed with HPV and p16-positive OPSCC in Stockholm 2000-2009, identified as having a partial/nonresponse to treatment and having viable tumour cells in their neck specimen with material available were categorized as cases. These were matched to controls (complete responders), and the differences in the gene expression were analysed. Two separate verification cohorts were identified including patients with HPV- and p16-positive OPSCC, and the data from the case-control study were verified by qPCR and immunohistochemistry (IHC) in the respective cohorts. A separation of gene expression in correlation with survival was observed in the case-control study, and FGF11 expression was identified as significantly differently expressed between the two groups. The prognostic role of FGF11 was validated in the two cohorts on the RNA and protein levels, respectively. Taken together, our findings suggest that FGF11 may indicate a poor prognosis in HPV-positive OPSCC and may serve as a prognostic biomarker.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

Nyckelord

FGF11
oropharyngeal cancer
tonsillar cancer
survival
prognosis

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