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WFRF:(Dellby Anette)
 

Sökning: WFRF:(Dellby Anette) > Dystrophia Helsingl...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003705nam a2200313 4500
001oai:DiVA.org:liu-17489
003SwePub
008090326| | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-174892 URI
040 a (SwePub)liu
041 a engb eng
042 9 SwePub
072 7a vet2 swepub-contenttype
072 7a ovr2 swepub-publicationtype
1001 a Neira, Waldiru Department of Ophthalmology, University of Helsinki, Helsinki, Finland4 aut
2451 0a Dystrophia Helsinglandica :b corneal morphology, topography and sensitivity in a hereditary corneal disease with recurrent erosive episodes
338 a print2 rdacarrier
520 a Purpose: The aim of this study was to describe the morphology, corneal topography and sensitivity in individuals with Dystrophia Helsinglandica. This autosomal dominant corneal disease is characterized by recurrent corneal erosive episodes and progressive subepithelial fibrosis not significantly affecting visual acuity. Methods: The corneas of nine affected and nine unaffected individuals were examined using slit‐lamp biomicroscopy, in‐vivo confocal microscopy, and videokeratography. Corneal mechanical sensitivity was also measured using a noncontact esthesiometer. Results: Slit‐lamp biomicroscopy revealed that the affected individuals represented different stages of corneal changes, from a nearly normal cornea to subepithelial fibrosis of the central cornea. Corneal changes in affected individuals did not significantly decrease the best spectacle‐corrected visual acuity. In‐vivo confocal microscopy detected morphological changes in the epithelium and stroma. Subepithelial opacity formation including altered keratocytes could be found in the anterior stroma in all affected eyes. With the exception of two eyes (one affected and one unaffected), all videokeratographies showed irregular astigmatism. Corneal sensitivity was significantly lower in affected individuals (p ≤0.01). Age and corneal sensitivity showed no correlation. Conclusion: The main morphological findings in affected individuals were discrete and progressive subepithelial fibrosis, in the in‐vivo confocal microscope corresponding to optically dense extracellular matrix and activated keratocytes. Subbasal nerve morphology was changed in the affected family members who also showed a decreased corneal sensitivity. The findings were per se not specific to the disease. The changes probably reflect a healing response to erosive events on the corneal surface influenced by the genotype.
653 a MEDICINE
653 a MEDICIN
7001 a Hammar, Björnu Östergötlands Läns Landsting,Linköpings universitet,Oftalmiatrik,Hälsouniversitetet,Ögonkliniken US/LiM4 aut
7001 a Holopainen, Juha M.u Department of Ophthalmology, University of Helsinki, Helsinki, Finland4 aut
7001 a Tuisku, Ilpou Department of Ophthalmology, University of Helsinki, Helsinki, Finland4 aut
7001 a Dellby, Anetteu Östergötlands Läns Landsting,Linköpings universitet,Oftalmiatrik,Hälsouniversitetet,Ögonkliniken US/LiM,Landstinget i Östergötland4 aut
7001 a Tervo, Timou Department of Ophthalmology, University of Helsinki, Helsinki, Finland4 aut
7001 a Fagerholm, Peru Östergötlands Läns Landsting,Linköpings universitet,Oftalmiatrik,Hälsouniversitetet,Ögonkliniken US/LiM4 aut0 (Swepub:liu)perfa04
7102 a Department of Ophthalmology, University of Helsinki, Helsinki, Finlandb Oftalmiatrik4 org
8564 u http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-17490y Link to Ph.D. Thesis
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-17489

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