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- Dizdar (Dizdar Segrell), NilLinköpings universitet,Neurologi,Hälsouniversitetet (författare)
Human pharmacokinetics of L-3,4-dihydroxyphenylalanine studied with microdialysis
- Artikel/kapitelEngelska1999
Förlag, utgivningsår, omfång ...
- 1999
- printrdacarrier
Nummerbeteckningar
- LIBRIS-ID:oai:DiVA.org:liu-13528
- https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-13528URI
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- Språk:engelska
- Sammanfattning på:engelska
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- SwePubSwePub
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- Background: Intravenous and subcutaneous microdialysis was performedto compare the free concentrations and pharmacokinetics of L-3,4-dihyroxyphenylalanine(L-dopa) in blood and tissue in healthy subjects and in patientswith Parkinson disease.Methods: Nine healthy volunteers and 10 patients with Parkinson disease, stage 1.5–2 according to the Hoehn-Yahr rating scale, took part of the study. In the patient group subcutaneous microdialysis and ordinary blood sampling were performed, whereas in the control group intravenous microdialysis was also performed. Microdialysis samples were collected in fractions of 15 min. The first two fractions were collected for analysis of basal concentrations. A blood sample was also taken. The patients were then given one tablet of Madopar® (100 mg of L-dopa and 25 mg of benserazide),and the microdialysis was continued for another 210 min. Bloodsamples were obtained at 30-min intervals.Results: The serum samples gave a significantly higher meanarea under the curve (AUC; 491 ± 139 µmol ·min/L) than that for intravenous dialysates (235 ± 55.3µmol · min/L), suggesting a protein binding of50%. The L-dopa concentrations from the subcutaneous dialysatesmatched those from the intravenous dialysates, indicating rapiddistribution of L-dopa to the tissues.Conclusions: Parkinsonian patients in early stages of the disease have a pharmacokinetic pattern of free L-dopa similar to that of healthy subjects. Comparison of AUCs from microdialysis with ordinary serum analysis revealed data indicating significant protein binding. Microdialysis is a suitable and easily applied tool in pharmacokinetic studies.
Ämnesord och genrebeteckningar
- MEDICINE
- MEDICIN
Biuppslag (personer, institutioner, konferenser, titlar ...)
- Kullman, AnitaLinköpings universitet,Klinisk kemi,Hälsouniversitetet(Swepub:liu)aniku95 (författare)
- Norlander, BjörnLinköpings universitet,Klinisk farmakologi,Hälsouniversitetet(Swepub:liu)bjono06 (författare)
- Olsson, Jan-EdvinÖstergötlands Läns Landsting,Linköpings universitet,Neurologi,Hälsouniversitetet,Neurologiska kliniken(Swepub:liu)janol82 (författare)
- Kågedal, BertilÖstergötlands Läns Landsting,Linköpings universitet,Klinisk kemi,Hälsouniversitetet(Swepub:liu)berka70 (författare)
- Linköpings universitetNeurologi (creator_code:org_t)
Sammanhörande titlar
- Ingår i:Clinical Chemistry45:10, s. 1813-18200009-91471530-8561
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- Kullman, Anita
- Norlander, Björn
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- Kågedal, Bertil
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- Clinical Chemist ...
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- Linköpings universitet
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