WFRF:(Ferraz Natalia 1976 )
Sökning: WFRF:(Ferraz Natalia 1976 ) > Bioactive nanocellu...
LIBRIS Formathandbok (Information om MARC21)
| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04984nam a2200469 4500 | |
| 001 | oai:DiVA.org:uu-498535 | |
| 003 | SwePub | |
| 008 | 230319s2023 | |||||||||||000 ||eng| | |
| 020 | a 9789151317564q print | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4985352 URI |
| 040 | a (SwePub)uu | |
| 041 | a engb engb -1 | |
| 042 | 9 SwePub | |
| 072 | 7 | a vet2 swepub-contenttype |
| 072 | 7 | a dok2 swepub-publicationtype |
| 100 | 1 | a Blasi Romero, Annau Uppsala universitet,Nanoteknologi och funktionella material4 aut0 (Swepub:uu)annbl717 |
| 245 | 1 0 | a Bioactive nanocellulose materials for the treatment of chronic wounds |
| 264 | 1 | a Uppsala :b Acta Universitatis Upsaliensis,c 2023 |
| 300 | a 83 s. | |
| 338 | a electronic2 rdacarrier | |
| 490 | 0 | a Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Science and Technology,x 1651-6214 ;v 2251 |
| 520 | a Chronic wounds represent a burden for the healthcare system and significantly affect the quality of life of the patients. There is currently a lack of efficient treatments but new, improved therapeutic approaches are under development. Suggested innovative wound care therapies consist on the topical administration of bioactive compounds aimed at restoring the balance in the wound environment and promoting the healing. However, their effectiveness is limited due to the highly oxidative and proteolytic environment in the chronic wound. In the work presented in this thesis, a series of bioactive nanocellulose-based materials were developed with the aim of addressing some of the present demands in chronic wound care. Wood-derived cellulose nanofibrils (CNFs) were functionalized with selected bioactive molecules expected to endow CNFs with the ability to modulate the chronic wound environment. Different chemical approaches were explored to combine CNFs with the following biomolecules: the amino acid cysteine, the peptide oligoproline and the host defense peptide KR-12. Materials were characterized in terms of chemical structure, degree of substitution and bioactivity.The immobilization of cysteine onto CNFs (cys-CNF) provided the material with radical oxygen species (ROS) scavenging properties and the ability to inhibit protease activity, properties that were related to the presence of free thiol groups on the nanofibers. Storage conditions in an inert atmosphere or in the form of aerogel were proposed to assure the long-term activity of the cys-CNF material. Investigations on the use of the ROS-sensitive oligoproline to crosslink CNFs provided optimized protocols to maximize peptide substitution and the degree of crosslinking. The oligoproline-CNF materials were sensitive to ROS-mediated cleavage and provided a protective effect to cells exposed to oxidative conditions. Moreover, the feasibility of preparing ROS-responsive drug delivery hydrogels based on the oligoproline-CNF was demonstrated, with indications that tuning the length of the oligoproline peptide could be exploited to tailor the release rate of small proteins. CNF materials with antibacterial properties and the ability to modulate the response of pro-inflammatory macrophages were obtained by immobilizing KR-12 derivatives onto CNFs. This study highlighted the importance in the selection of the conjugation chemistry to preserve the activity of the peptide once immobilized. To conclude, this work has contributed with valuable strategies to develop bioactive CNF-based materials with the potential of paving the way for advanced solutions in the field of chronic wound care. | |
| 520 | a | |
| 650 | 7 | a TEKNIK OCH TEKNOLOGIERx Nanoteknik0 (SwePub)2102 hsv//swe |
| 650 | 7 | a ENGINEERING AND TECHNOLOGYx Nano-technology0 (SwePub)2102 hsv//eng |
| 653 | a cellulose nanofibrils | |
| 653 | a covalent immobilization | |
| 653 | a wound healing | |
| 653 | a antioxidant properties | |
| 653 | a antibacterial properties | |
| 653 | a anti-inflammatory properties | |
| 653 | a stimuli responsive hydrogels | |
| 653 | a reactive oxygen species | |
| 653 | a host defense peptides | |
| 653 | a Teknisk fysik med inriktning mot nanoteknologi och funktionella material | |
| 653 | a Engineering Science with specialization in Nanotechnology and Functional Materials | |
| 700 | 1 | a Ferraz, Natalia,c Associate Professor,d 1976-u Uppsala universitet,Nanoteknologi och funktionella material4 ths0 (Swepub:uu)natfe727 |
| 700 | 1 | a Aili, Daniel,c Professoru Linköping University, Department of Physics, Chemistry and Biology, and Department of Biophysics and bioengineering4 opn |
| 710 | 2 | a Uppsala universitetb Nanoteknologi och funktionella material4 org |
| 856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:1744426/FULLTEXT01.pdfx primaryx Raw objecty fulltext |
| 856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:1744426/PREVIEW01.jpgx Previewy preview image |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-498535 |
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