Mesenchymal Stromal Cells Are More Immunosuppressive In Vitro If They Are Derived from Endometriotic Lesions than from Eutopic Endometrium

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Fältnamn	Indikatorer	Metadata
000		02694naa a2200277 4500
001		oai:prod.swepub.kib.ki.se:137003705
003		SwePub
008		240811s2017 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:1370037052 URI
024	7	a https://doi.org/10.1155/2017/32159622 DOI
040		a (SwePub)ki
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Abomaray, Fu Karolinska Institutet4 aut
245	1 0	a Mesenchymal Stromal Cells Are More Immunosuppressive In Vitro If They Are Derived from Endometriotic Lesions than from Eutopic Endometrium
264	1	b Hindawi Limited,c 2017
520		a Endometriosis is an inflammatory disease with predominance of immunosuppressive M2 macrophages in the pelvic cavity that could be involved in the pathology through support and immune escape of ectopic lesions. Mesenchymal stromal cells (MSC) are found in ectopic lesions, and MSC from nonendometriosis sources are known to induce M2 macrophages. Therefore, MSC were hypothesized to play a role in the pathology of endometriosis. The aim was to characterize the functional phenotype of MSC in ectopic and eutopic endometrium from women with endometriosis. Stromal cells from endometriotic ovarian cysts (ESCcyst) and endometrium (ESCendo) were examined if they exhibited a MSC phenotype. Then, ESC were phenotypically examined for protein and gene expression of immunosuppressive and immunostimulatory molecules. Finally, ESC were functionally examined for their effects on monocyte differentiation into macrophages. ESCcystand ESCendoexpressed MSC markers, formed colonies, and differentiated into osteoblasts and adipocytes. Phenotypically, ESCcystwere more immunosuppressive, with significantly higher expression of immunosuppressive molecules. Functionally, ESCcystinduced more spindle-shaped macrophages, with significantly higher expression of CD14 and CD163, both features of M2 macrophages. The results suggest that ESCcystmay be more immunosuppressive than ESCendoand may promote immunosuppressive M2 macrophages that may support growth and reduce immunosurveillance of ectopic lesions.
700	1	a Gidlof, Su Karolinska Institutet4 aut
700	1	a Gotherstrom, Cu Karolinska Institutet4 aut
710	2	a Karolinska Institutet4 org
773	0	t Stem cells internationald : Hindawi Limitedg 2017, s. 3215962-q 2017<3215962-x 1687-966Xx 1687-9678
856	4	u http://downloads.hindawi.com/journals/sci/2017/3215962.pdf
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:137003705
856	4 8	u https://doi.org/10.1155/2017/3215962

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Av författaren/redakt...: Abomaray, F; Gidlof, S; Gotherstrom, C

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Av lärosätet: Karolinska Institutet

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