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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00006041naa a2200649 4500
001oai:gup.ub.gu.se/286737
003SwePub
008240528s2019 | |||||||||||000 ||eng|
009oai:DiVA.org:uu-397643
0247 a https://gup.ub.gu.se/publication/2867372 URI
0247 a https://doi.org/10.1111/1471-0528.159472 DOI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3976432 URI
040 a (SwePub)gud (SwePub)uu
041 a eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Cluver, C. A.u Stellenbosch Univ, Dept Obstet & Gynaecol, Francie van Zyl Dr, ZA-7505 Cape Town, South Africa;Mercy Hosp Women, Mercy Perinatal, Melbourne, Vic, Australia; Univ Melbourne, Translat Obstet Grp, Melbourne, Vic, Australia4 aut
2451 0a The association of prenatal alcohol exposure on the cognitive abilities and behaviour profiles of 4-year-old children: a prospective cohort study
264 c 2019-10-10
264 1b Wiley,c 2019
520 a ObjectiveTo examine the association of prenatal alcohol exposure (PAE) on cognitive abilities and behaviour profiles of 4-year-old children. DesignProspective cohort study. SettingCape Town, South Africa. PopulationA cohort of 500 children. MethodsChildren from the Safe Passage Study, which prospectively collected PAE, were included. Cognition and behavioural profiles were assessed. Children with and without PAE were compared. Mean scores were compared, with P <= 0.05 considered significant. Results were adjusted for confounding factors. Main outcome measuresThe Kaufman Assessment Battery for children measured intellectual and mental ability; the NEPSY-II instrument assessed neurocognitive performance. The caregiver completed the Preschool Child Behaviour checklist to rate the child's problem behaviours and competencies. ResultsTwo hundred children had no PAE, 117 children had mild to moderate PAE (with no binge episodes), 113 children had heavy PAE (with one or two binge episodes), and 70 children had very heavy PAE (with three or more binge episodes). Women who binge drank had significantly higher rates of smoking, marijuana use, and methamphetamine use. Low to moderate PAE had no effect on cognitive ability and behaviour. Very heavy PAE was associated with problems performing simultaneous as well as sequential functions, lower scores in the language and sensorimotor domain, and more attention and pervasive developmental problems. ConclusionsLow to moderate PAE was not associated with cognitive processing or developmental problems. Women who had many binge drinking episodes during pregnancy were the most at risk for cognitive processing, neurocognitive, and behaviour problems in their children at 4 years of age. Tweetable abstractLow to moderate prenatal alcohol use was not associated with cognitive or behavioural problems in 4-year-olds. Tweetable abstract Low to moderate prenatal alcohol use was not associated with cognitive or behavioural problems in 4-year-olds.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskap0 (SwePub)3032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Health Sciences0 (SwePub)3032 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reproduktionsmedicin och gynekologi0 (SwePub)302202 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Obstetrics, Gynaecology and Reproductive Medicine0 (SwePub)302202 hsv//eng
653 a Alcohol
653 a behaviour
653 a cognitive function
653 a neurocognitive function
653 a pregnancy
653 a prenatal alcohol exposure
653 a light drinking
653 a binge drinking
653 a early-pregnancy
653 a age
653 a deficits
653 a risk
653 a intelligence
653 a consumption
653 a attention
653 a patterns
653 a Alcohol
7001 a Charles, W.u Stellenbosch Univ, Dept Obstet & Gynaecol, Cape Town, South Africa4 aut
7001 a van der Merwe, C.u Stellenbosch Univ, Dept Psychiat, Cape Town, South Africa; Tygerberg Hosp, Cape Town, South Africa4 aut
7001 a Bezuidenhout, H.u Tygerberg Hosp, Cape Town, South Africa; Stellenbosch Univ, Dept Biomed Sci, Div Mol Biol & Human Genet, Cape Town, South Africa4 aut
7001 a Nel, D.u Stellenbosch Univ, Ctr Stat Consultat, Stellenbosch, South Africa4 aut
7001 a Groenewald, C.u Stellenbosch Univ, Dept Obstet & Gynaecol, Cape Town, South Africa4 aut
7001 a Hesselman, Susanne,d 1973-u Uppsala universitet,Klinisk obstetrik,Centrum för klinisk forskning Dalarna4 aut0 (Swepub:uu)sushe649
7001 a Bergman, Lina,d 1982u Uppsala universitet,Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology,Centrum för klinisk forskning Dalarna,Klinisk obstetrik,Stellenbosch Univ, Dept Obstet & Gynaecol, Cape Town, South Africa; Univ Gothenburg, Sahlgrenska Acad, Inst Clin Sci, Dept Obstet & Gynaecol, Gothenburg, Sweden4 aut0 (Swepub:uu)linbe681
7001 a Odendaal, H.u Stellenbosch Univ, Dept Obstet & Gynaecol, Cape Town, South Africa4 aut
7001 a Brink, L.u Stellenbosch Univ, Dept Obstet & Gynaecol, Cape Town, South Africa4 aut
7102 a Stellenbosch Univ, Dept Obstet & Gynaecol, Francie van Zyl Dr, ZA-7505 Cape Town, South Africa;Mercy Hosp Women, Mercy Perinatal, Melbourne, Vic, Australia; Univ Melbourne, Translat Obstet Grp, Melbourne, Vic, Australiab Stellenbosch Univ, Dept Obstet & Gynaecol, Cape Town, South Africa4 org
7730 t Bjog-an International Journal of Obstetrics and Gynaecologyd : Wileyg 126:13, s. 1588-1597q 126:13<1588-1597x 1470-0328x 1471-0528
8564 8u https://gup.ub.gu.se/publication/286737
8564 8u https://doi.org/10.1111/1471-0528.15947
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-397643

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