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  • Heymer, Emma J.University of Birmingham (author)

Risk of subsequent gliomas and meningiomas among 69,460 5-year survivors of childhood and adolescent cancer in Europe : the PanCareSurFup study

  • Article/chapterEnglish2024

Publisher, publication year, extent ...

  • 2024

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:87322128-6969-4e7b-8cb5-7e49bf0c6b92
  • https://lup.lub.lu.se/record/87322128-6969-4e7b-8cb5-7e49bf0c6b92URI
  • https://doi.org/10.1038/s41416-024-02577-yDOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:154785539URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Background: Childhood cancer survivors are at risk of subsequent gliomas and meningiomas, but the risks beyond age 40 years are uncertain. We quantified these risks in the largest ever cohort. Methods: Using data from 69,460 5-year childhood cancer survivors (diagnosed 1940–2008), across Europe, standardized incidence ratios (SIRs) and cumulative incidence were calculated. Results: In total, 279 glioma and 761 meningioma were identified. CNS tumour (SIR: 16.2, 95% CI: 13.7, 19.2) and leukaemia (SIR: 11.2, 95% CI: 8.8, 14.2) survivors were at greatest risk of glioma. The SIR for CNS tumour survivors was still 4.3-fold after age 50 (95% CI: 1.9, 9.6), and for leukaemia survivors still 10.2-fold after age 40 (95% CI: 4.9, 21.4). Following cranial radiotherapy (CRT), the cumulative incidence of a glioma in CNS tumour survivors was 2.7%, 3.7% and 5.0% by ages 40, 50 and 60, respectively, whilst for leukaemia this was 1.2% and 1.7% by ages 40 and 50. The cumulative incidence of a meningioma after CRT in CNS tumour survivors doubled from 5.9% to 12.5% between ages 40 and 60, and in leukaemia survivors increased from 5.8% to 10.2% between ages 40 and 50. Discussion: Clinicians following up survivors should be aware that the substantial risks of meningioma and glioma following CRT are sustained beyond age 40 and be vigilant for symptoms.

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Added entries (persons, corporate bodies, meetings, titles ...)

  • Hawkins, Michael M.University of Birmingham (author)
  • Winter, David L.University of Birmingham (author)
  • Teepen, Jop C.Princess Maxima Center for Pediatric Oncology/Hematology (author)
  • Sunguc, CerenUniversity of Birmingham (author)
  • Ronckers, Cécile M.Princess Maxima Center for Pediatric Oncology/Hematology,Johannes-Gutenberg University Mainz (author)
  • Allodji, Rodrigue S.Centre for Research in Epidemiology and Population Health (CESP) (author)
  • Alessi, DanielaUniversity of Turin (author)
  • Sugden, ElaineUniversity of Birmingham (author)
  • Belle, Fabiën N.University of Bern,University of Lausanne (author)
  • Bagnasco, FrancescaGaslini Children's Hospital (author)
  • Byrne, JulianneBoyne Research Institute (author)
  • Bárdi, EditKepler University Hospital Linz,St. Anna Children's Hospital (author)
  • Garwicz, StanislawLund University,Lunds universitet,Sena effekter efter barncancerbehandling,Forskargrupper vid Lunds universitet,Late effects after childhood cancer treatment,Lund University Research Groups(Swepub:lu)st6750ga (author)
  • Grabow, DesireeJohannes-Gutenberg University Mainz (author)
  • Jankovic, MomciloUniversity of Milano-Bicocca (author)
  • Kaatsch, PeterJohannes-Gutenberg University Mainz (author)
  • Kaiser, MelanieJohannes-Gutenberg University Mainz (author)
  • Michel, GiselaUniversity of Lucerne (author)
  • Schindera, ChristinaUniversity Children's Hospital, Basel,University of Bern (author)
  • Haddy, NadiaCentre for Research in Epidemiology and Population Health (CESP) (author)
  • Journy, NeigeCentre for Research in Epidemiology and Population Health (CESP) (author)
  • Česen Mazić, MajaUniversity Children's Hospital, Ljubljana (author)
  • Skinner, RoderickUniversity of Newcastle upon Tyne (author)
  • Kok, Judith L.Princess Maxima Center for Pediatric Oncology/Hematology (author)
  • Gunnes, Maria W.Norwegian Radium Hospital,Cancer Registry of Norway, Institute of Population-Based Cancer Research (author)
  • Wiebe, ThomasLund University,Lunds universitet,Sena effekter efter barncancerbehandling,Forskargrupper vid Lunds universitet,Late effects after childhood cancer treatment,Lund University Research Groups(Swepub:lu)pedi-twi (author)
  • Sacerdote, CarlottaUniversity of Turin (author)
  • Maule, Milena M.University of Turin (author)
  • Terenziani, MonicaIstituto Nazionale dei Tumori (author)
  • Jakab, ZsuzsannaSemmelweis University (author)
  • Winther, Jeanette F.Danish Cancer Society,Aarhus University Hospital (author)
  • Lähteenmäki, Päivi M.Turku University Hospital (author)
  • Zadravec Zaletel, LornaInstitute of Oncology, Ljubljana (author)
  • Haupt, RiccardoGaslini Children's Hospital (author)
  • Kuehni, Claudia E.University of Bern,University Children's Hospital Bern (author)
  • Kremer, Leontien C.Princess Maxima Center for Pediatric Oncology/Hematology,Academic Medical Center of University of Amsterdam (AMC) (author)
  • de Vathaire, FlorentCentre for Research in Epidemiology and Population Health (CESP) (author)
  • Hjorth, LarsLund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Sena effekter efter barncancerbehandling,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Late effects after childhood cancer treatment,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Skåne University Hospital(Swepub:lu)pedi-lhj (author)
  • Reulen, Raoul C.University of Birmingham (author)
  • University of BirminghamPrincess Maxima Center for Pediatric Oncology/Hematology (creator_code:org_t)

Related titles

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