A Micro-CT and Synchrotron Imaging Study of the Human Endolymphatic Duct with Special Reference to Endolymph Outflow and Meniere's Disease

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Fältnamn	Indikatorer	Metadata
000		03213naa a2200409 4500
001		oai:DiVA.org:uu-406752
003		SwePub
008		200311s2020 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4067522 URI
024	7	a https://doi.org/10.1038/s41598-020-65110-02 DOI
040		a (SwePub)uu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Kämpfe Nordström, Charlottau Uppsala universitet,Öron-, näs- och halssjukdomar4 aut0 (Swepub:uu)chano188
245	1 0	a A Micro-CT and Synchrotron Imaging Study of the Human Endolymphatic Duct with Special Reference to Endolymph Outflow and Meniere's Disease
264		c 2020-05-19
264	1	b Springer Science and Business Media LLC,c 2020
338		a electronic2 rdacarrier
500		a De tre sista författarna delar sistaförfattarskapet
520		a Meniere’s disease remains enigmatic, and has no treatment with sufficient evidence. The characteristic histopathological finding is endolymphatic hydrops, suggesting either an overproduction or decreased reabsorption of endolymph in the human inner ear. This study presents the first analysis of the vascular plexus around the human endolymphatic duct using micro computed tomography and coherent synchrotron radiation with phase contrast imaging. Using a software program, data were processed by volume-rendering with scalar opacity mapping to create transparent three-dimensional reconstructions. A rich vascular plexus was discovered around the endolymphatic duct that drained into collecting channels, linked to the vestibular venous outflow system. This network is believed to make up the principal route for endolymph outflow, and its associated malfunction may result in endolymphatic hydrops and Meniere’s disease.
650	7	a TEKNIK OCH TEKNOLOGIERx Medicinteknikx Medicinsk bildbehandling0 (SwePub)206032 hsv//swe
650	7	a ENGINEERING AND TECHNOLOGYx Medical Engineeringx Medical Image Processing0 (SwePub)206032 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Medicinsk bioteknologix Biomedicinsk laboratorievetenskap/teknologi0 (SwePub)304022 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Medical Biotechnologyx Biomedical Laboratory Science/Technology0 (SwePub)304022 hsv//eng
700	1	a Li, Hao,d 1984-u Uppsala universitet,Öron-, näs- och halssjukdomar4 aut0 (Swepub:uu)haoli805
700	1	a Ladak, Hanif M.4 aut
700	1	a Agrawal, Sumit4 aut
700	1	a Rask-Andersen, Helgeu Uppsala universitet,Öron-, näs- och halssjukdomar4 aut0 (Swepub:uu)helgraan
710	2	a Uppsala universitetb Öron-, näs- och halssjukdomar4 org
773	0	t Scientific Reportsd : Springer Science and Business Media LLCg 10:1q 10:1x 2045-2322
856	4	u https://doi.org/10.1038/s41598-020-65110-0y Fulltext
856	4	u https://uu.diva-portal.org/smash/get/diva2:1414004/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
856	4	u https://www.nature.com/articles/s41598-020-65110-0.pdf
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-406752
856	4 8	u https://doi.org/10.1038/s41598-020-65110-0

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