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Sökning: WFRF:(Lindskog A.) > (2015-2019) > Protein profiles of...

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FältnamnIndikatorerMetadata
00007415naa a2200661 4500
001oai:DiVA.org:kth-194276
003SwePub
008161021s2016 | |||||||||||000 ||eng|
009oai:DiVA.org:uu-306274
009oai:prod.swepub.kib.ki.se:134264183
009oai:DiVA.org:uu-491780
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-1942762 URI
0247 a https://doi.org/10.1111/all.129272 DOI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3062742 URI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1342641832 URI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4917802 URI
040 a (SwePub)kthd (SwePub)uud (SwePub)kid (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Hamsten, C.u Karolinska Institutet,Immunology and Allergy Unit; Department of Medicine Solna; Karolinska Institutet; and Karolinska University Hospital;Center for Inflammatory Diseases; Karolinska Institutet; Stockholm Sweden4 aut
2451 0a Protein profiles of CCL5, HPGDS, and NPSR1 in plasma reveal association with childhood asthma
264 c 2016-05-25
264 1b Blackwell Publishing,c 2016
338 a print2 rdacarrier
500 a QC 20161024
520 a Asthma is a common chronic childhood disease with many different phenotypes that need to be identified. We analyzed a broad range of plasma proteins in children with well-characterized asthma phenotypes to identify potential markers of childhood asthma. Using an affinity proteomics approach, plasma levels of 362 proteins covered by antibodies from the Human Protein Atlas were investigated in a total of 154 children with persistent or intermittent asthma and controls. After screening, chemokine ligand 5 (CCL5) hematopoietic prostaglandin D synthase (HPGDS) and neuropeptide S receptor 1 (NPSR1) were selected for further investigation. Significantly lower levels of both CCL5 and HPGDS were found in children with persistent asthma, while NPSR1 was found at higher levels in children with mild intermittent asthma compared to healthy controls. In addition, the protein levels were investigated in another respiratory disease, sarcoidosis, showing significantly higher NPSR1 levels in sera from sarcoidosis patients compared to healthy controls. Immunohistochemical staining of healthy tissues revealed high cytoplasmic expression of HPGDS in mast cells, present in stroma of both airway epithelia, lung as well as in other organs. High expression of NPSR1 was observed in neuroendocrine tissues, while no expression was observed in airway epithelia or lung. In conclusion, we have utilized a broad-scaled affinity proteomics approach to identify three proteins with altered plasma levels in asthmatic children, representing one of the first evaluations of HPGDS and NPSR1 protein levels in plasma.
650 7a NATURVETENSKAPx Biologix Immunologi0 (SwePub)106052 hsv//swe
650 7a NATURAL SCIENCESx Biological Sciencesx Immunology0 (SwePub)106052 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Lungmedicin och allergi0 (SwePub)302192 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Respiratory Medicine and Allergy0 (SwePub)302192 hsv//eng
653 a asthma
653 a biomarker
653 a childhood
653 a plasma
653 a protein
653 a Biology with specialization in Molecular Biology
7001 a Häggmark, Anna,d 1985-u KTH,Science for Life Laboratory, SciLifeLab,Affinitets-proteomik,KTH Royal Inst Technol, Sch Biotechnol, SciLifeLab, Affin Prote, Stockholm, Sweden.,Affinity Proteomics; SciLifeLab; School of Biotechnology; KTH-Royal Institute of Technology; Stockholm Sweden4 aut0 (Swepub:kth)u1g5roxd
7001 a Grundstrom, J.u Karolinska Institutet,Immunology and Allergy Unit; Department of Medicine Solna; Karolinska Institutet; and Karolinska University Hospital4 aut
7001 a Mikus, Mariau Karolinska Institutet,KTH,Proteomik och nanobioteknologi,KTH Royal Inst Technol, Sch Biotechnol, SciLifeLab, Affin Prote, Stockholm, Sweden.,Karolinska Inst, Inst Environm Med, Stockholm, Sweden.;Soder Sjukhuset, Sachs Children & Youth Hosp, Stockholm, Sweden.,Karolinska Inst, Immunol & Allergy Unit, Dept Med Solna, Stockholm, Sweden.;Karolinska Univ Hosp, Stockholm, Sweden.,Affinity Proteomics; SciLifeLab; School of Biotechnology; KTH-Royal Institute of Technology; Stockholm Sweden,Institute of Environmental Medicine; Karolinska Institutet; Stockholm Sweden;Sachs’ Children and Youth Hospital; Södersjukhuset; Stockholm Sweden,Immunology and Allergy Unit; Department of Medicine Solna; Karolinska Institutet; and Karolinska University Hospital4 aut0 (Swepub:kth)u1qjoszn
7001 a Lindskog, Ceciliau Uppsala universitet,Institutionen för immunologi, genetik och patologi,Science for Life Laboratory, SciLifeLab,Cancerprecisionsmedicin,SciLifeLab; Department of Immunology; Genetics and Pathology; Uppsala University; Uppsala Sweden4 aut0 (Swepub:uu)cecli129
7001 a Konradsen, J. R.u Karolinska Institutet,Astrid Lindgren Children's Hospital; Karolinska University Hospital; Stockholm Sweden;Department of Women's and Children's Health; Karolinska Institutet; Stockholm Sweden4 aut
7001 a Eklund, A.u Karolinska Institutet,Respiratory Medicine Unit; Department of Medicine Solna and CMM; Karolinska Institutet and Karolinska University Hospital; Stockholm Sweden4 aut
7001 a Pershagen, G.u Karolinska Institutet,Institute of Environmental Medicine; Karolinska Institutet; Stockholm Sweden4 aut
7001 a Wickman, M.4 aut
7001 a Grunewald, J.u Karolinska Institutet,Respiratory Medicine Unit; Department of Medicine Solna and CMM; Karolinska Institutet and Karolinska University Hospital; Stockholm Sweden4 aut
7001 a Melen, E.u Karolinska Institutet,Institute of Environmental Medicine; Karolinska Institutet; Stockholm Sweden;Sachs’ Children and Youth Hospital; Södersjukhuset; Stockholm Sweden4 aut
7001 a Hedlin, G.u Karolinska Institutet,Astrid Lindgren Children's Hospital; Karolinska University Hospital; Stockholm Sweden;Department of Women's and Children's Health; Karolinska Institutet; Stockholm Sweden4 aut
7001 a Nilsson, Peteru KTH,Proteomik och nanobioteknologi,KTH Royal Inst Technol, Sch Biotechnol, SciLifeLab, Affin Prote, Stockholm, Sweden.,Affinity Proteomics; SciLifeLab; School of Biotechnology; KTH-Royal Institute of Technology; Stockholm Sweden4 aut0 (Swepub:kth)u1ws88sk
7001 a van Hage, M.4 aut
7102 a Karolinska Institutetb Immunology and Allergy Unit; Department of Medicine Solna; Karolinska Institutet; and Karolinska University Hospital;Center for Inflammatory Diseases; Karolinska Institutet; Stockholm Sweden4 org
7730 t Allergy. European Journal of Allergy and Clinical Immunologyd : Blackwell Publishingg 71:9, s. 1357-1361q 71:9<1357-1361x 0105-4538x 1398-9995
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-194276
8564 8u https://doi.org/10.1111/all.12927
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-306274
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:134264183
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-491780

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