Present and Future Therapeutic Approaches to Barrier Dysfunction

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Present and Future Therapeutic Approaches to Barrier Dysfunction

Fortea, Marina (författare): Laboratory for Enteric NeuroScience, Translational Research Center for GastroIntestinal Disorders, University of Leuven, Leuven, Belgium,Univ Leuven, Belgium

Albert-Bayo, Mercé (författare): Laboratory of Neuro-Immuno-Gastroenterology, Digestive System Research Unit, Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron Hospital Universitari, Barcelona, Spain,Vall dHebron Hosp Univ, Spain

Abril-Gil, Mar (författare): Laboratory of Neuro-Immuno-Gastroenterology, Digestive System Research Unit, Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron Hospital Universitari, Barcelona, Spain,Vall dHebron Hosp Univ, Spain

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Ganda Mall, John-Peter, 1988- (författare): Linköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Vall dHebron Hosp Univ, Spain

Serra-Ruiz, Xavier (författare): Department of Gastroenterology, Vall d'Hebron Hospital Universitari, Barcelona, Spain,Vall dHebron Hosp Univ, Spain

Henao-Paez, Alejandro (författare): Department of Gastroenterology, Vall d'Hebron Hospital Universitari, Barcelona, Spain,Vall dHebron Hosp Univ, Spain

Expósito, Elba (författare): Laboratory of Neuro-Immuno-Gastroenterology, Digestive System Research Unit, Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron Hospital Universitari, Barcelona, Spain,Vall dHebron Hosp Univ, Spain

González-Castro, Ana María (författare): Laboratory of Neuro-Immuno-Gastroenterology, Digestive System Research Unit, Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron Hospital Universitari, Barcelona, Spain,Vall dHebron Hosp Univ, Spain

Guagnozzi, Danila (författare): Laboratory of Neuro-Immuno-Gastroenterology, Digestive System Research Unit, Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron Hospital Universitari, Barcelona, Spain; Department of Gastroenterology, Vall d'Hebron Hospital Universitari, Barcelona, Spain; Facultad de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERHED), Instituto de Salud Carlos III, Madrid, Spain,Vall dHebron Hosp Univ, Spain; Vall dHebron Hosp Univ, Spain; Univ Autonoma Barcelona, Spain; Inst Salud Carlos III, Spain

Lobo, Beatriz (författare): Laboratory of Neuro-Immuno-Gastroenterology, Digestive System Research Unit, Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron Hospital Universitari, Barcelona, Spain; Department of Gastroenterology, Vall d'Hebron Hospital Universitari, Barcelona, Spain; Facultad de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain,Vall dHebron Hosp Univ, Spain; Vall dHebron Hosp Univ, Spain; Univ Autonoma Barcelona, Spain

Alonso-Cotoner, Carmen (författare): Laboratory of Neuro-Immuno-Gastroenterology, Digestive System Research Unit, Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron Hospital Universitari, Barcelona, Spain; Department of Gastroenterology, Vall d'Hebron Hospital Universitari, Barcelona, Spain; Facultad de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERHED), Instituto de Salud Carlos III, Madrid, Spain,Vall dHebron Hosp Univ, Spain; Vall dHebron Hosp Univ, Spain; Univ Autonoma Barcelona, Spain; Inst Salud Carlos III, Spain

Santos, Javier (författare): Laboratory of Neuro-Immuno-Gastroenterology, Digestive System Research Unit, Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron Hospital Universitari, Barcelona, Spain; Department of Gastroenterology, Vall d'Hebron Hospital Universitari, Barcelona, Spain; Facultad de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERHED), Instituto de Salud Carlos III, Madrid, Spain,Vall dHebron Hosp Univ, Spain; Vall dHebron Hosp Univ, Spain; Univ Autonoma Barcelona, Spain; Inst Salud Carlos III, Spain

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2021-10-28
2021
Engelska.
Ingår i: Frontiers in Nutrition. - : Frontiers Media S.A.. - 2296-861X. ; 8

Relaterad länk:: https://doi.org/10.3...; visa fler...; https://www.frontier...; https://liu.diva-por... (primary) (Raw object); https://urn.kb.se/re...; https://doi.org/10.3...; https://urn.kb.se/re...; visa färre...

Forskningsöversikt (refereegranskat)

Abstract Ämnesord

Stäng

There is converging and increasing evidence, but also uncertainty, for the role of abnormal intestinal epithelial barrier function in the origin and development of a growing number of human gastrointestinal and extraintestinal inflammatory disorders, and their related complaints. Despite a vast literature addressing factors and mechanisms underlying changes in intestinal permeability in humans, and its connection to the appearance and severity of clinical symptoms, the ultimate link remains to be established in many cases. Accordingly, there are no directives or clinical guidelines related to the therapeutic management of intestinal permeability disorders that allow health professionals involved in the management of these patients to carry out a consensus treatment based on clinical evidence. Instead, there are multiple pseudoscientific approaches and commercial propaganda scattered on the internet that confuse those affected and health professionals and that often lack scientific rigor. Therefore, in this review we aim to shed light on the different therapeutic options, which include, among others, dietary management, nutraceuticals and medical devices, microbiota and drugs, and epigenetic and exosomes-manipulation, through an objective evaluation of the scientific publications in this field. Advances in the knowledge and management of intestinal permeability will sure enable better options of dealing with this group of common disorders to enhance quality of life of those affected.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Hälso- och sjukvårdsorganisation, hälsopolitik och hälsoekonomi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Health Care Service and Management, Health Policy and Services and Health Economy (hsv//eng)

Nyckelord

Epithelial barrier function
intestinal permeability
mast cell stabilizers
mucoprotectants
nutrients
prebiotics
probiotics
short chain fatty acids

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Av författaren/redakt...: Fortea, Marina; Albert-Bayo, Mer ...; Abril-Gil, Mar; Ganda Mall, John ...; Serra-Ruiz, Xavi ...; Henao-Paez, Alej ...; visa fler...; Expósito, Elba; González-Castro, ...; Guagnozzi, Danil ...; Lobo, Beatriz; Alonso-Cotoner, ...; Santos, Javier; visa färre...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Hälsovetenskap; och Folkhälsovetensk ...

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Hälsovetenskap; och Hälso och sjukvå ...

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Av lärosätet: Örebro universitet; Linköpings universitet

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