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Present and Future ...
Present and Future Therapeutic Approaches to Barrier Dysfunction
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- Fortea, Marina (author)
- Laboratory for Enteric NeuroScience, Translational Research Center for GastroIntestinal Disorders, University of Leuven, Leuven, Belgium,Univ Leuven, Belgium
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- Albert-Bayo, Mercé (author)
- Laboratory of Neuro-Immuno-Gastroenterology, Digestive System Research Unit, Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron Hospital Universitari, Barcelona, Spain,Vall dHebron Hosp Univ, Spain
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- Abril-Gil, Mar (author)
- Laboratory of Neuro-Immuno-Gastroenterology, Digestive System Research Unit, Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron Hospital Universitari, Barcelona, Spain,Vall dHebron Hosp Univ, Spain
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- Ganda Mall, John-Peter, 1988- (author)
- Linköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Vall dHebron Hosp Univ, Spain
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- Serra-Ruiz, Xavier (author)
- Department of Gastroenterology, Vall d'Hebron Hospital Universitari, Barcelona, Spain,Vall dHebron Hosp Univ, Spain
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- Henao-Paez, Alejandro (author)
- Department of Gastroenterology, Vall d'Hebron Hospital Universitari, Barcelona, Spain,Vall dHebron Hosp Univ, Spain
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- Expósito, Elba (author)
- Laboratory of Neuro-Immuno-Gastroenterology, Digestive System Research Unit, Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron Hospital Universitari, Barcelona, Spain,Vall dHebron Hosp Univ, Spain
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- González-Castro, Ana María (author)
- Laboratory of Neuro-Immuno-Gastroenterology, Digestive System Research Unit, Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron Hospital Universitari, Barcelona, Spain,Vall dHebron Hosp Univ, Spain
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- Guagnozzi, Danila (author)
- Laboratory of Neuro-Immuno-Gastroenterology, Digestive System Research Unit, Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron Hospital Universitari, Barcelona, Spain; Department of Gastroenterology, Vall d'Hebron Hospital Universitari, Barcelona, Spain; Facultad de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERHED), Instituto de Salud Carlos III, Madrid, Spain,Vall dHebron Hosp Univ, Spain; Vall dHebron Hosp Univ, Spain; Univ Autonoma Barcelona, Spain; Inst Salud Carlos III, Spain
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- Lobo, Beatriz (author)
- Laboratory of Neuro-Immuno-Gastroenterology, Digestive System Research Unit, Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron Hospital Universitari, Barcelona, Spain; Department of Gastroenterology, Vall d'Hebron Hospital Universitari, Barcelona, Spain; Facultad de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain,Vall dHebron Hosp Univ, Spain; Vall dHebron Hosp Univ, Spain; Univ Autonoma Barcelona, Spain
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- Alonso-Cotoner, Carmen (author)
- Laboratory of Neuro-Immuno-Gastroenterology, Digestive System Research Unit, Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron Hospital Universitari, Barcelona, Spain; Department of Gastroenterology, Vall d'Hebron Hospital Universitari, Barcelona, Spain; Facultad de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERHED), Instituto de Salud Carlos III, Madrid, Spain,Vall dHebron Hosp Univ, Spain; Vall dHebron Hosp Univ, Spain; Univ Autonoma Barcelona, Spain; Inst Salud Carlos III, Spain
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- Santos, Javier (author)
- Laboratory of Neuro-Immuno-Gastroenterology, Digestive System Research Unit, Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron Hospital Universitari, Barcelona, Spain; Department of Gastroenterology, Vall d'Hebron Hospital Universitari, Barcelona, Spain; Facultad de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERHED), Instituto de Salud Carlos III, Madrid, Spain,Vall dHebron Hosp Univ, Spain; Vall dHebron Hosp Univ, Spain; Univ Autonoma Barcelona, Spain; Inst Salud Carlos III, Spain
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(creator_code:org_t)
- 2021-10-28
- 2021
- English.
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In: Frontiers in Nutrition. - : Frontiers Media S.A.. - 2296-861X. ; 8
- Related links:
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https://doi.org/10.3...
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https://www.frontier...
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https://liu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Subject headings
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- There is converging and increasing evidence, but also uncertainty, for the role of abnormal intestinal epithelial barrier function in the origin and development of a growing number of human gastrointestinal and extraintestinal inflammatory disorders, and their related complaints. Despite a vast literature addressing factors and mechanisms underlying changes in intestinal permeability in humans, and its connection to the appearance and severity of clinical symptoms, the ultimate link remains to be established in many cases. Accordingly, there are no directives or clinical guidelines related to the therapeutic management of intestinal permeability disorders that allow health professionals involved in the management of these patients to carry out a consensus treatment based on clinical evidence. Instead, there are multiple pseudoscientific approaches and commercial propaganda scattered on the internet that confuse those affected and health professionals and that often lack scientific rigor. Therefore, in this review we aim to shed light on the different therapeutic options, which include, among others, dietary management, nutraceuticals and medical devices, microbiota and drugs, and epigenetic and exosomes-manipulation, through an objective evaluation of the scientific publications in this field. Advances in the knowledge and management of intestinal permeability will sure enable better options of dealing with this group of common disorders to enhance quality of life of those affected.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Hälso- och sjukvårdsorganisation, hälsopolitik och hälsoekonomi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Health Care Service and Management, Health Policy and Services and Health Economy (hsv//eng)
Keyword
- Epithelial barrier function
- intestinal permeability
- mast cell stabilizers
- mucoprotectants
- nutrients
- prebiotics
- probiotics
- short chain fatty acids
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- By the author/editor
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Fortea, Marina
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Albert-Bayo, Mer ...
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Abril-Gil, Mar
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Ganda Mall, John ...
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Serra-Ruiz, Xavi ...
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Henao-Paez, Alej ...
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Expósito, Elba
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González-Castro, ...
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Guagnozzi, Danil ...
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Lobo, Beatriz
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Alonso-Cotoner, ...
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Santos, Javier
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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MEDICAL AND HEAL ...
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- Articles in the publication
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Frontiers in Nut ...
- By the university
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Örebro University
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Linköping University