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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00009833naa a2200889 4500
001oai:DiVA.org:uu-451558
003SwePub
008210909s2021 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4515582 URI
0247 a https://doi.org/10.1038/s41598-021-91742-x2 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Esteve-Codina, Annau Barcelona Inst Sci & Technol BIST, Ctr Genom Regulat CRG, CNAG CRG, Barcelona, Spain.;Univ Pompeu Fabra UPF, Barcelona, Spain.4 aut
2451 0a Gender specific airway gene expression in COPD sub-phenotypes supports a role of mitochondria and of different types of leukocytes
264 c 2021-06-18
264 1b Springer Nature,c 2021
338 a electronic2 rdacarrier
520 a Chronic obstructive pulmonary disease (COPD) is a destructive inflammatory disease and the genes expressed within the lung are crucial to its pathophysiology. We have determined the RNAseq transcriptome of bronchial brush cells from 312 stringently defined ex-smoker patients. Compared to healthy controls there were for males 40 differentially expressed genes (DEGs) and 73 DEGs for females with only 26 genes shared. The gene ontology (GO) term "response to bacterium" was shared, with several different DEGs contributing in males and females. Strongly upregulated genes TCN1 and CYP1B1 were unique to males and females, respectively. For male emphysema (E)-dominant and airway disease (A)-dominant COPD (defined by computed tomography) the term "response to stress" was found for both sub-phenotypes, but this included distinct up-regulated genes for the E-sub-phenotype (neutrophil-related CSF3R, CXCL1, MNDA) and for the A-sub-phenotype (macrophage-related KLF4, F3, CD36). In E-dominant disease, a cluster of mitochondria-encoded (MT) genes forms a signature, able to identify patients with emphysema features in a confirmation cohort. The MT-CO2 gene is upregulated transcriptionally in bronchial epithelial cells with the copy number essentially unchanged. Both MT-CO2 and the neutrophil chemoattractant CXCL1 are induced by reactive oxygen in bronchial epithelial cells. Of the female DEGs unique for E- and A-dominant COPD, 88% were detected in females only. In E-dominant disease we found a pronounced expression of mast cell-associated DEGs TPSB2, TPSAB1 and CPA3. The differential genes discovered in this study point towards involvement of different types of leukocytes in the E- and A-dominant COPD sub-phenotypes in males and females.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Lungmedicin och allergi0 (SwePub)302192 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Respiratory Medicine and Allergy0 (SwePub)302192 hsv//eng
7001 a Hofer, Thomas P.u Helmholtz Zentrum Muenchen & Asklepios Klin, EvA Study Ctr, Gauting, Germany.;Helmholtz Zentrum Muenchen, Immunoanalyt Core Facil, Munich, Germany.4 aut
7001 a Burggraf, Dorotheu Helmholtz Zentrum Muenchen & Asklepios Klin, EvA Study Ctr, Gauting, Germany.4 aut
7001 a Heiss-Neumann, Marion S.u Helmholtz Zentrum Muenchen & Asklepios Klin, EvA Study Ctr, Gauting, Germany.4 aut
7001 a Gesierich, Wolfgangu Helmholtz Zentrum Muenchen & Asklepios Klin, EvA Study Ctr, Gauting, Germany.4 aut
7001 a Boland, Anneu Univ Paris Saclay, CEA, Inst Biol Francois Jacob, Ctr Natl Rech Genom Humaine CNRGH, Evry, France.4 aut
7001 a Olaso, Robertu Univ Paris Saclay, CEA, Inst Biol Francois Jacob, Ctr Natl Rech Genom Humaine CNRGH, Evry, France.4 aut
7001 a Bihoreau, Marie-Thereseu Univ Paris Saclay, CEA, Inst Biol Francois Jacob, Ctr Natl Rech Genom Humaine CNRGH, Evry, France.4 aut
7001 a Deleuze, Jean-Francoisu Univ Paris Saclay, CEA, Inst Biol Francois Jacob, Ctr Natl Rech Genom Humaine CNRGH, Evry, France.4 aut
7001 a Moeller, Winfriedu Helmholtz Zentrum Muenchen, Inst Lung Biol & Dis, Neuherberg, Germany.4 aut
7001 a Schmid, Otmaru Helmholtz Zentrum Muenchen, Inst Lung Biol & Dis, Neuherberg, Germany.4 aut
7001 a Artigas, Maria Soleru Barcelona Inst Sci & Technol BIST, Ctr Genom Regulat CRG, CNAG CRG, Barcelona, Spain.;Univ Pompeu Fabra UPF, Barcelona, Spain.4 aut
7001 a Renner, Kathrinu Univ Hosp Regensburg, Internal Med 3, Regensburg, Germany.4 aut
7001 a Hohlfeld, Jens M.u Fraunhofer Inst Toxicol & Expt Med, Hannover, Germany.;Hannover Med Sch, Dept Resp Med, Hannover, Germany.;German Ctr Lung Res DZL, Hannover, Germany.4 aut
7001 a Welte, Tobiasu Hannover Med Sch, Dept Resp Med, Hannover, Germany.;German Ctr Lung Res DZL, Hannover, Germany.4 aut
7001 a Fuehner, Thomasu Hannover Med Sch, Dept Resp Med, Hannover, Germany.;German Ctr Lung Res DZL, Hannover, Germany.4 aut
7001 a Jerrentrup, Lukasu German Ctr Lung Res DZL, Marburg, Germany.;Philipps Univ, Univ Med Ctr Giessen & Marburg, Dept Med Pulm & Crit Care Med, Marburg, Germany.4 aut
7001 a Koczulla, Andreas Rembertu German Ctr Lung Res DZL, Marburg, Germany.;Philipps Univ, Univ Med Ctr Giessen & Marburg, Dept Med Pulm & Crit Care Med, Marburg, Germany.4 aut
7001 a Greulich, Timmu German Ctr Lung Res DZL, Marburg, Germany.;Philipps Univ, Univ Med Ctr Giessen & Marburg, Dept Med Pulm & Crit Care Med, Marburg, Germany.4 aut
7001 a Prasse, Antjeu Fraunhofer Inst Toxicol & Expt Med, Hannover, Germany.;Hannover Med Sch, Dept Resp Med, Hannover, Germany.;German Ctr Lung Res DZL, Hannover, Germany.4 aut
7001 a Mueller-Quernheim, Joachimu Univ Freiburg, Fac Med, Dept Pneumol, Freiburg, Germany.4 aut
7001 a Gupta, Sumitu Univ Leicester, NIHR Leicester BRC, Inst Lung Hlth, Leicester, Leics, England.4 aut
7001 a Brightling, Christopheru Univ Leicester, NIHR Leicester BRC, Inst Lung Hlth, Leicester, Leics, England.4 aut
7001 a Subramanian, Deepak R.u Univ Hosp Coventry & Warwickshire NHS Trust, Dept Resp Med, Coventry, W Midlands, England.4 aut
7001 a Parr, David G.u Univ Hosp Coventry & Warwickshire NHS Trust, Dept Resp Med, Coventry, W Midlands, England.4 aut
7001 a Kolsum, Ummeu Univ Manchester, Univ Hosp South Manchester Fdn Trust, Med Evaluat Unit, Manchester, Lancs, England.4 aut
7001 a Gupta, Vandanau Univ Manchester, Univ Hosp South Manchester Fdn Trust, Med Evaluat Unit, Manchester, Lancs, England.4 aut
7001 a Barta, Imreu Natl Koranyi Inst TB & Pulmonol, Dept Pathophysiol, Budapest, Hungary.4 aut
7001 a Dome, Balazsu Natl Koranyi Inst TB & Pulmonol, Dept Tumorbiol, Budapest, Hungary.4 aut
7001 a Strausz, Janosu Natl Koranyi Inst TB & Pulmonol, Dept Pneumol, Budapest, Hungary.4 aut
7001 a Stendardo, Mariaritau Univ Ferrara, Dept Med Sci, Ferrara, Italy.;Ferrara City Hosp, Ferrara, Italy.4 aut
7001 a Piattella, Marcou Univ Ferrara, Dept Med Sci, Ferrara, Italy.;Ferrara City Hosp, Ferrara, Italy.4 aut
7001 a Boschetto, Pierau Univ Ferrara, Dept Med Sci, Ferrara, Italy.;Ferrara City Hosp, Ferrara, Italy.4 aut
7001 a Korzybski, Damianu Natl Inst TB & Lung Dis, Dept Resp Med 2, Warsaw, Poland.4 aut
7001 a Gorecka, Dorotau Natl Inst TB & Lung Dis, Dept Resp Med 2, Warsaw, Poland.4 aut
7001 a Nowinski, Adam4 aut
7001 a Dabad, Marcu Barcelona Inst Sci & Technol BIST, Ctr Genom Regulat CRG, CNAG CRG, Barcelona, Spain.;Univ Pompeu Fabra UPF, Barcelona, Spain.4 aut
7001 a Fernandez-Callejo, Marcosu Barcelona Inst Sci & Technol BIST, Ctr Genom Regulat CRG, CNAG CRG, Barcelona, Spain.;Univ Pompeu Fabra UPF, Barcelona, Spain.4 aut
7001 a Endesfelder, Davidu Helmholtz Zentrum Muenchen, ICT Dept, Munich, Germany.4 aut
7001 a zu Castell, Wolfgangu Helmholtz Zentrum Muenchen, Dept Strategy & Digitalizat, Munich, Germany.;Tech Univ Munich, Fac Math, Munich, Germany.4 aut
7001 a Hiemstra, Pieter S.u Leiden Univ, Dept Pulmonol, Med Ctr, Leiden, Netherlands.4 aut
7001 a Venge, Peru Uppsala universitet,Klinisk kemi4 aut0 (Swepub:uu)pervenge
7001 a Noessner, Elfriedeu Helmholtz Zentrum Muenchen, Immunoanalyt Tissue Control Immunocytes, Munich, Germany.4 aut
7001 a Griebel, Thassou Barcelona Inst Sci & Technol BIST, Ctr Genom Regulat CRG, CNAG CRG, Barcelona, Spain.;Univ Pompeu Fabra UPF, Barcelona, Spain.4 aut
7001 a Heath, Simonu Barcelona Inst Sci & Technol BIST, Ctr Genom Regulat CRG, CNAG CRG, Barcelona, Spain.;Univ Pompeu Fabra UPF, Barcelona, Spain.4 aut
7001 a Singh, Daveu Univ Manchester, Univ Hosp South Manchester Fdn Trust, Med Evaluat Unit, Manchester, Lancs, England.4 aut
7001 a Gut, Ivou Barcelona Inst Sci & Technol BIST, Ctr Genom Regulat CRG, CNAG CRG, Barcelona, Spain.;Univ Pompeu Fabra UPF, Barcelona, Spain.4 aut
7001 a Ziegler-Heitbrock, Loemsu Helmholtz Zentrum Muenchen & Asklepios Klin, EvA Study Ctr, Gauting, Germany.4 aut
7102 a Barcelona Inst Sci & Technol BIST, Ctr Genom Regulat CRG, CNAG CRG, Barcelona, Spain.;Univ Pompeu Fabra UPF, Barcelona, Spain.b Helmholtz Zentrum Muenchen & Asklepios Klin, EvA Study Ctr, Gauting, Germany.;Helmholtz Zentrum Muenchen, Immunoanalyt Core Facil, Munich, Germany.4 org
7730 t Scientific Reportsd : Springer Natureg 11:1q 11:1x 2045-2322
8564 u https://doi.org/10.1038/s41598-021-91742-xy Fulltext
8564 u https://uu.diva-portal.org/smash/get/diva2:1592741/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 u https://www.nature.com/articles/s41598-021-91742-x.pdf
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-451558
8564 8u https://doi.org/10.1038/s41598-021-91742-x

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