Recent Smell Loss Is the Best Predictor of COVID-19 Among Individuals With Recent Respiratory Symptoms

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Gerkin, Richard C. (author)

Recent Smell Loss Is the Best Predictor of COVID-19 Among Individuals With Recent Respiratory Symptoms

Article/chapterEnglish2021

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2020-12-25
Oxford University Press (OUP),2021
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LIBRIS-ID:oai:DiVA.org:su-195563
https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-195563URI
https://doi.org/10.1093/chemse/bjaa081DOI
http://kipublications.ki.se/Default.aspx?queryparsed=id:149039254URI

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Language:English
Summary in:English

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SwePubSwePub

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

In a preregistered, cross-sectional study, we investigated whether olfactory loss is a reliable predictor of COVID-19 using a crowdsourced questionnaire in 23 languages to assess symptoms in individuals self-reporting recent respiratory illness. We quantified changes in chemosensory abilities during the course of the respiratory illness using 0–100 visual analog scales (VAS) for participants reporting a positive (C19+; n = 4148) or negative (C19−; n = 546) COVID-19 laboratory test outcome. Logistic regression models identified univariate and multivariate predictors of COVID-19 status and post-COVID-19 olfactory recovery. Both C19+ and C19− groups exhibited smell loss, but it was significantly larger in C19+ participants (mean ± SD, C19+: −82.5 ± 27.2 points; C19−: −59.8 ± 37.7). Smell loss during illness was the best predictor of COVID-19 in both univariate and multivariate models (ROC AUC = 0.72). Additional variables provide negligible model improvement. VAS ratings of smell loss were more predictive than binary chemosensory yes/no-questions or other cardinal symptoms (e.g., fever). Olfactory recovery within 40 days of respiratory symptom onset was reported for ~50% of participants and was best predicted by time since respiratory symptom onset. We find that quantified smell loss is the best predictor of COVID-19 amongst those with symptoms of respiratory illness. To aid clinicians and contact tracers in identifying individuals with a high likelihood of having COVID-19, we propose a novel 0–10 scale to screen for recent olfactory loss, the ODoR-19. We find that numeric ratings ≤2 indicate high odds of symptomatic COVID-19 (4 < OR < 10). Once independently validated, this tool could be deployed when viral lab tests are impractical or unavailable.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Neurovetenskaper hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Neurosciences hsv//eng
anosmia
chemosensory
coronavirus
hyposmia
olfactory
prediction
psykologi
Psychology

Added entries (persons, corporate bodies, meetings, titles ...)

Ohla, Kathrin (author)
Veldhuizen, Maria G. (author)
Joseph, Paule (author)
Kelly, Christine E. (author)
Bakke, Alyssa J. (author)
Steele, Kimberley E. (author)
Farruggia, Michael C. (author)
Pellegrino, Robert (author)
Pepino, Marta Y. (author)
Bouysset, Cedric (author)
Soler, Graciela M. (author)
Pereda-Loth, Veronica (author)
Dibattista, Michele (author)
Cooper, Keiland W. (author)
Croijmans, Ilja (author)
Di Pizio, Antonella (author)
Ozdener, Mehmet Hakan (author)
Fjaeldstad, Alexander W. (author)
Lin, Cailu (author)
Sandell, Mari A. (author)
Singh, Preet B. (author)
Brindha, V. Evelyn (author)
Olsson, Shannon B. (author)
Saraiva, Luis R. (author)
Ahuja, Gaurav (author)
Alwashahi, Mohammed K. (author)
Bhutani, Surabhi (author)
D'Errico, Anna (author)
Fornazieri, Marco A. (author)
Golebiowski, Jerome (author)
Hwang, Liang Dar (author)
Ozturk, Lina (author)
Roura, Eugeni (author)
Spinelli, Sara (author)
Whitcroft, Katherine L. (author)
Faraji, Farhoud (author)
Fischmeister, Florian Ph S. (author)
Heinbockel, Thomas (author)
Hsieh, Julien W. (author)
Huart, Caroline (author)
Konstantinidis, Iordanis (author)
Menini, Anna (author)
Morini, Gabriella (author)
Olofsson, Jonas K.,1978-Stockholms universitet,Psykologiska institutionen(Swepub:su)jool8931 (author)
Philpott, Carl M. (author)
Pierron, Denis (author)
Shields, Vonnie D. C. (author)
Voznessenskaya, Vera V. (author)
Albayay, Javier (author)
Altundag, Aytug (author)
Bensafi, Moustafa (author)
Bock, Maria Adelaida (author)
Calcinoni, Orietta (author)
Fredborg, WilliamStockholms universitet,Psykologiska institutionen(Swepub:su)wifr5556 (author)
Laudamiel, Christophe (author)
Lim, Juyun (author)
Lundstrom, Johan N.Karolinska Institutet (author)
Macchi, Alberto (author)
Meyer, Pablo (author)
Moein, Shima T. (author)
Santamaria, Enrique (author)
Sengupta, Debarka (author)
Dominguez, Paloma Rohlfs (author)
Yanik, Huseyin (author)
Hummel, Thomas (author)
Hayes, John E. (author)
Reed, Danielle R. (author)
Niv, Masha Y. (author)
Munger, Steven D. (author)
Parma, Valentina (author)
Stockholms universitetPsykologiska institutionen (creator_code:org_t)

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In:Chemical Senses: Oxford University Press (OUP)460379-864X1464-3553

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By the author/editor: Gerkin, Richard ...; Ohla, Kathrin; Veldhuizen, Mari ...; Joseph, Paule; Kelly, Christine ...; Bakke, Alyssa J.; show more...; Steele, Kimberle ...; Farruggia, Micha ...; Pellegrino, Robe ...; Pepino, Marta Y.; Bouysset, Cedric; Soler, Graciela ...; Pereda-Loth, Ver ...; Dibattista, Mich ...; Cooper, Keiland ...; Croijmans, Ilja; Di Pizio, Antone ...; Ozdener, Mehmet ...; Fjaeldstad, Alex ...; Lin, Cailu; Sandell, Mari A.; Singh, Preet B.; Brindha, V. Evel ...; Olsson, Shannon ...; Saraiva, Luis R.; Ahuja, Gaurav; Alwashahi, Moham ...; Bhutani, Surabhi; D'Errico, Anna; Fornazieri, Marc ...; Golebiowski, Jer ...; Hwang, Liang Dar; Ozturk, Lina; Roura, Eugeni; Spinelli, Sara; Whitcroft, Kathe ...; Faraji, Farhoud; Fischmeister, Fl ...; Heinbockel, Thom ...; Hsieh, Julien W.; Huart, Caroline; Konstantinidis, ...; Menini, Anna; Morini, Gabriell ...; Olofsson, Jonas ...; Philpott, Carl M ...; Pierron, Denis; Shields, Vonnie ...; Voznessenskaya, ...; Albayay, Javier; Altundag, Aytug; Bensafi, Moustaf ...; Bock, Maria Adel ...; Calcinoni, Oriet ...; Fredborg, Willia ...; Laudamiel, Chris ...; Lim, Juyun; Lundstrom, Johan ...; Macchi, Alberto; Meyer, Pablo; Moein, Shima T.; Santamaria, Enri ...; Sengupta, Debark ...; Dominguez, Palom ...; Yanik, Huseyin; Hummel, Thomas; Hayes, John E.; Reed, Danielle R ...; Niv, Masha Y.; Munger, Steven D ...; Parma, Valentina; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Neurosciences

Articles in the publication: Chemical Senses

By the university: Stockholm University; Karolinska Institutet

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